Novel etiological and therapeutic strategies for neurodiseases: epigenetic understanding of gene-environment interactions.

abstract：:Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exog...

journal_title：Journal of pharmacological sciences

authors： Kitamura Y,Takata K,Inden M,Tsuchiya D,Yanagisawa D,Nakata J,Taniguchi T

更新日期：2004-02-01 00:00:00

abstract：:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells duri...

journal_title：Journal of pharmacological sciences

authors： Takahashi-Yanaga F,Sasaguri T

更新日期：2007-08-01 00:00:00

abstract：:SU11274, a small molecule inhibitor of c-Met, was reported to induce apoptosis in human non-small-cell lung cancer (NSCLC) cells. However, SU11274-mediated autophagy in NSCLC cells has rarely been reported. The aim of this study was to elucidate the molecular mechanisms mediating SU11274-induced autophagy in NSCLC A54...

journal_title：Journal of pharmacological sciences

authors： Liu Y,Yang Y,Ye YC,Shi QF,Chai K,Tashiro S,Onodera S,Ikejima T

更新日期：2012-01-01 00:00:00

abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

journal_title：Journal of pharmacological sciences

authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

更新日期：2003-03-01 00:00:00

abstract：:Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the residual risk for ischemic events remains substantial. The high resid...

journal_title：Journal of pharmacological sciences

authors： Chintala M,Shimizu K,Ogawa M,Yamaguchi H,Doi M,Jensen P

更新日期：2008-12-01 00:00:00

abstract：:The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social...

journal_title：Journal of pharmacological sciences

authors： Nakashima MN,Ajiki K,Nakashima K,Takahashi M

更新日期：2003-01-01 00:00:00

abstract：:The L-type Ca(2+) channel (Ca(V)1.2) shows clear Ca(2+)-dependent facilitation and inactivation. Here we have examined the effects of calmodulin (CaM) and Ca(2+) on Ca(2+) channel in guinea-pig ventricular myocytes in the inside-out patch mode, where rundown of the channels was controlled. At a free [Ca(2+)] of 0.1 mi...

journal_title：Journal of pharmacological sciences

authors： Han DY,Minobe E,Wang WY,Guo F,Xu JJ,Hao LY,Kameyama M

更新日期：2010-01-01 00:00:00

abstract：:This study was undertaken to evaluate the differences in chronotherapeutic effects of angiotensin-II receptor blockers, valsartan and olmesartan in hypertensive patients with non-dipper blood pressure (BP) pattern during valsartan at morning. Ninety four patients were enrolled, and 40 patients were judged to be non-di...

journal_title：Journal of pharmacological sciences

authors： Ushijima K,Nakashima H,Shiga T,Harada K,Ishikawa S,Ioka T,Ando H,Fujimura A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Clinical efficacy of allergen-specific Immunotherapy (AIT) towards Japanese cedar (JC) pollen allergy is firmly established but JC pollen-specific biomarker assays are lacking. Treatment-related increase of allergen-specific antibodies is a robust biomarker of successful AIT. Allergen-specific non-IgE antibo...

journal_title：Journal of pharmacological sciences

authors： Fukano C,Ohashi-Doi K,Lund K,Nakao A,Masuyama K,Matsuoka T

更新日期：2019-07-01 00:00:00

abstract：:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-b...

journal_title：Journal of pharmacological sciences

authors： Saito H

更新日期：2008-03-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are important public health problems. The global prevalence of diabetes mellitus is 8.8%. Interventional diabetology and obesitology have been recently advocated as treatment options for T2D and obesity. The roles of metabolic surgery such as Roux-en-Y gastric bypass, sleeve gastrecto...

journal_title：Journal of pharmacological sciences

authors： Syu YF,Inui A,Chen CY

更新日期：2017-02-01 00:00:00

abstract：:The GABAergic system in the spinal cord has been shown to participate in neuropathic pain in various animal models. GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; however, their role in neuropathic pain remains unclear. In the present study, we compared the betaine/GABA transporter...

journal_title：Journal of pharmacological sciences

authors： Jinzenji A,Sogawa C,Miyawaki T,Wen XF,Yi D,Ohyama K,Kitayama S,Sogawa N,Morita K

更新日期：2014-01-01 00:00:00

abstract：:Intrathecal (i.t.) administration of D-cycloserine (100 and 300 fmol), a partial agonist of the glycine recognition site on the N-methyl-D-aspartate (NMDA) receptor ion-channel complex, produced a behavioral response mainly consisting of biting and/or licking of the hindpaw and the tail along with slight hindlimb scra...

journal_title：Journal of pharmacological sciences

authors： Tan-No K,Esashi A,Nakagawasai O,Niijima F,Furuta S,Sato T,Satoh S,Yasuhara H,Tadano T

更新日期：2007-05-01 00:00:00

abstract：:In canine ventricular myocardium, endothelin-1 (ET-1) alone induced only a weak transient negative inotropic effect (NIE). However, ET-1 induced a marked sustained positive inotropic effect (PIE) subsequent to a transient NIE in the presence of norepinephrine (NE) at low concentrations (0.1 - 1 nM) and elicited a pron...

journal_title：Journal of pharmacological sciences

authors： Chu L,Zhang JX,Norota I,Endoh M

更新日期：2005-03-01 00:00:00

abstract：:Evidence has shown that hyperlipidemia is associated with retinoid dyshomeostasis. In liver, retinol is mainly oxidized to retinal by retinol dehydrogenases (RDHs) and alcohol dehydrogenases (ADHs), further converted to retinoic acid by retinal dehydrogenases (RALDHs). The aim of this study was to investigate whether ...

journal_title：Journal of pharmacological sciences

authors： Zhang M,Liu C,Hu MY,Zhang J,Xu P,Li F,Zhong ZY,Liu L,Liu XD

更新日期：2015-04-01 00:00:00

abstract：:This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-88...

journal_title：Journal of pharmacological sciences

authors： Kuraishi Y,Ohtsuka E,Nakano T,Kawai S,Andoh T,Nojima H,Kamimura K

更新日期：2007-09-01 00:00:00

abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

journal_title：Journal of pharmacological sciences

authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

更新日期：2007-06-01 00:00:00

abstract：:The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings sugg...

journal_title：Journal of pharmacological sciences

authors： Andoh M,Ikegaya Y,Koyama R

更新日期：2020-12-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) contributes to the acceleration of insulin signaling. However, the mechanism by which AMPK regulates insulin signaling remains unclear. Serine phosphorylation of insulin receptor substrate (IRS)-1 negatively regulates insulin signaling. Here we investigated the role of AMPK in serin...

journal_title：Journal of pharmacological sciences

authors： Shibata T,Takaguri A,Ichihara K,Satoh K

更新日期：2013-01-01 00:00:00

abstract：:Resveratrol is a stilbene compound found in grapes and other sources. In this study we examined the effects of trans-resveratrol (4.38 - 438 microM/implant) in the vasculogenesis of yolk-sac membranes and its capacity to improve chick embryo growth. High concentrations of the stilbene (43.8 - 438 microM) significantly...

journal_title：Journal of pharmacological sciences

authors： Dias PF,Berti FV,Siqueira JM Jr,Maraschin M,Gagliardi AR,Ribeiro-do-Valle RM

更新日期：2008-06-01 00:00:00

abstract：:Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

journal_title：Journal of pharmacological sciences

authors： Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

更新日期：2009-12-01 00:00:00

abstract：:The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

journal_title：Journal of pharmacological sciences

authors： Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

更新日期：2007-10-01 00:00:00

abstract：:Previously, we reported that specific lower dose of sodium 2,3-dimercapto-1-propanesulfonic acid (DMPS) which is an antidote to heavy metal intoxication, inversely enhanced cisplatin (CDDP)-induced antitumor activity to S-180 cell-bearing mouse. This activity was only weak with meso-2,3-dimercaptosuccinic acid (DMSA),...

journal_title：Journal of pharmacological sciences

authors： Yajima Y,Kawaguchi M,Yoshikawa M,Okubo M,Tsukagoshi E,Sato K,Katakura A

更新日期：2017-06-01 00:00:00

abstract：:Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used in this study balloo...

journal_title：Journal of pharmacological sciences

authors： Seto Y,Yoshida N,Kaneko H

更新日期：2011-01-01 00:00:00

abstract：:Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC staining ratio was strongest in L929 cells. 3-Methyladenine...

journal_title：Journal of pharmacological sciences

authors： Yu J,Li X,Tashiro S,Onodera S,Ikejima T

更新日期：2008-07-01 00:00:00

abstract：:The role of the Na+ current in the automaticity of the pulmonary vein myocardium was examined in isolated guinea pig pulmonary vein cardiomyocytes and tissue preparations. Tetrodotoxin inhibited the automaticity of pulmonary vein tissue preparations by suppressing the diastolic depolarization of the action potential. ...

journal_title：Journal of pharmacological sciences

authors： Irie M,Hiiro H,Hamaguchi S,Namekata I,Tanaka H

更新日期：2019-09-01 00:00:00

abstract：:IAP antagonists increased the antitumor efficacy of X-irradiation in some types of cancers, but their effects on hypoxic cancer cells remain unclarified. We aims to investigate the radiosensitizing effect of an IAP inhibitor AT-406 on cervical cancer cell lines under both normoxia and hypoxia conditions. Hela and Siha...

journal_title：Journal of pharmacological sciences

authors： Lu J,Qin Q,Zhan LL,Liu J,Zhu HC,Yang X,Zhang C,Xu LP,Liu ZM,Wang D,Cui HQ,Meng CC,Cai J,Cheng HY,Sun XC

更新日期：2014-01-01 00:00:00

abstract：:Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significan...

journal_title：Journal of pharmacological sciences

authors： Na HJ,Moon PD,Ko SG,Lee HJ,Jung HA,Hong SH,Seo Y,Oh JM,Lee BH,Choi BW,Kim HM

更新日期：2005-02-01 00:00:00

abstract：:Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca(2+) transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca(2+) concentration begins to rise earliest at the Z-line level and becomes uniform throughout the cytoplasm within about 10 ...

journal_title：Journal of pharmacological sciences

authors： Tanaka H,Kawanishi T,Shigenobu K

更新日期：2003-11-01 00:00:00

abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

journal_title：Journal of pharmacological sciences

authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

更新日期：2016-03-01 00:00:00