Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells.

abstract：:In conventional relative gene expression analysis (Northern blotting, RT-PCR, and in situ hybridization), housekeeping genes such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin genes, whose expression levels are considered stable, have been used as control genes for normalization of RNA quantit...

journal_title：Journal of pharmacological sciences

authors： Nishida Y,Sugahara-Kobayashi M,Takahashi Y,Nagata T,Ishikawa K,Asai S

更新日期：2006-05-01 00:00:00

abstract：:Antipsychotics are often used in conjunction with anti-Alzheimer drugs to treat the behavioral and psychological symptoms of dementia (BPSD). Here, we examined the effects of cholinesterase inhibitors (ChEIs), donepezil and galantamine, on antipsychotic-induced extrapyramidal side effects (EPS) in mice. The effects of...

journal_title：Journal of pharmacological sciences

authors： Shimizu S,Mizuguchi Y,Sobue A,Fujiwara M,Morimoto T,Ohno Y

更新日期：2015-04-01 00:00:00

abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

journal_title：Journal of pharmacological sciences

authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

更新日期：2003-03-01 00:00:00

abstract：:A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 microM [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum immediately. Like capsaicin, [6]-gingerol-induced contraction was in...

journal_title：Journal of pharmacological sciences

authors： Someya A,Horie S,Yamamoto H,Murayama T

更新日期：2003-08-01 00:00:00

abstract：:Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated. We investigated the therapeutic effects of melittin on muscle in...

journal_title：Journal of pharmacological sciences

authors： Lee JE,Shah VK,Lee EJ,Oh MS,Choi JJ

更新日期：2019-05-01 00:00:00

abstract：:We investigated the anesthetic effects of propofol on the electrocardiogram (ECG) in mice. We also compared the effects of isoflurane (2%) inhalation anesthesia, intraperitoneal propofol (50 or 100 mg/kg), and pentobarbital (50 mg/kg) on ECG in mice. Isoflurane inhalation and pentobarbital anesthesia were both associa...

journal_title：Journal of pharmacological sciences

authors： Shintaku T,Ohba T,Niwa H,Kushikata T,Hirota K,Ono K,Matsuzaki Y,Imaizumi T,Kuwasako K,Sawamura D,Murakami M

更新日期：2014-01-01 00:00:00

abstract：:Intestinal Cl- secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The present study aimed to ...

journal_title：Journal of pharmacological sciences

authors： Pongkorpsakol P,Yimnual C,Chatsudthipong V,Rukachaisirikul V,Muanprasat C

更新日期：2017-06-01 00:00:00

abstract：:To elucidate the mechanism of action of prostaglandin I(2) (PGI(2)) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Hepatocyte parenchymal cells, maintained in a serum-free, defined medium, synthesized DNA and proliferated in the presence ...

journal_title：Journal of pharmacological sciences

authors： Kimura M,Okamoto H,Natsume H,Ogihara M

更新日期：2009-04-01 00:00:00

abstract：:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-b...

journal_title：Journal of pharmacological sciences

authors： Saito H

更新日期：2008-03-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug that can potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance, a disorder that induces urticaria, asthma, and anaphylaxis in response to oral administration of the dr...

journal_title：Journal of pharmacological sciences

authors： Suzuki Y,Ra C

更新日期：2009-07-01 00:00:00

abstract：:Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various diseases such as pneumonia, diarrhea, and hepatitis. Recent studies have demonstrated that baicalin possesses a wide range of pha...

journal_title：Journal of pharmacological sciences

authors： Kim ME,Kim HK,Park HY,Kim DH,Chung HY,Lee JS

更新日期：2013-01-01 00:00:00

abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

journal_title：Journal of pharmacological sciences

authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

更新日期：2017-01-01 00:00:00

abstract：:Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal sacral dorsal commissural nucleus neurons. In the present study,...

journal_title：Journal of pharmacological sciences

authors： Yamaga T,Aou S,Shin MC,Wakita M,Akaike N

更新日期：2012-01-01 00:00:00

abstract：:We investigated the roles of β- and α(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol,...

journal_title：Journal of pharmacological sciences

authors： Deyama S,Takishita A,Tanimoto S,Ide S,Nakagawa T,Satoh M,Minami M

更新日期：2010-01-01 00:00:00

abstract：:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, sig...

journal_title：Journal of pharmacological sciences

authors： Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

更新日期：2010-01-01 00:00:00

abstract：:Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice. The three-drug combined treatment displayed a pote...

journal_title：Journal of pharmacological sciences

authors： Fernández-Dueñas V,Poveda R,Sánchez S,Ciruela F

更新日期：2012-01-01 00:00:00

abstract：:We investigated the inhibitory effects of β₁- or β₂-adrenoceptor (AR) antagonists on salivary amylase secretion produced by various emetic agents, such as cisplatin, apomorphine, and lithium chloride (LiCl), or the non-emetic agent β(½)-AR agonist isoprenaline in rats. We also determined the inhibitory effect of metoc...

journal_title：Journal of pharmacological sciences

authors： Fukui H,Suyama Y,Iwachido T,Miwa E

更新日期：2011-01-01 00:00:00

abstract：:Cytochrome P450 (CYP) catalyzes the oxidation of many endogenous and xenobiotic compounds. The expression of CYP isozymes are modulated by endogenous hormones and xenobiotics. We found that, although CYP2C11 and CYP3A2 are adult male-specific isozymes, they are also expressed in prepubertal female Sprague Dawley (SD) ...

journal_title：Journal of pharmacological sciences

authors： Ishii T,Nishimura K,Nishimura M

更新日期：2006-07-01 00:00:00

abstract：:The biological basis for the therapeutic mechanisms of depression are still unknown. While performing EST (expressed sequence tag) analysis to identify some molecular machinery responsible for the antidepressant effect, we determined the full-length nucleotide sequence of rat frizzled-3 protein (Frz3) cDNA. Interestin...

journal_title：Journal of pharmacological sciences

authors： Yamada M,Iwabuchi T,Takahashi K,Kurahashi C,Ohata H,Honda K,Higuchi T,Yamada M

更新日期：2005-11-01 00:00:00

abstract：:We recently reported that physiological concentrations of 17beta-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K(+) currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17beta-estradiol, we investigated r...

journal_title：Journal of pharmacological sciences

authors： Kakusaka S,Asayama M,Kaihara A,Sasano T,Suzuki T,Kurokawa J,Furukawa T

更新日期：2009-01-01 00:00:00

abstract：:Previously, we reported that specific lower dose of sodium 2,3-dimercapto-1-propanesulfonic acid (DMPS) which is an antidote to heavy metal intoxication, inversely enhanced cisplatin (CDDP)-induced antitumor activity to S-180 cell-bearing mouse. This activity was only weak with meso-2,3-dimercaptosuccinic acid (DMSA),...

journal_title：Journal of pharmacological sciences

authors： Yajima Y,Kawaguchi M,Yoshikawa M,Okubo M,Tsukagoshi E,Sato K,Katakura A

更新日期：2017-06-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:Butyrate is widely accepted as a proliferation inhibitor in colon cancer but less thoroughly characterized in the colonic epithelium of objects with type 2 diabetes mellitus. The present study investigated the regulatory effect of butyrate on proliferation, the related molecule high-mobility group box 1 (HMGB1) and th...

journal_title：Journal of pharmacological sciences

authors： Wang SY,Li JY,Xu JH,Xia ZS,Cheng D,Zhong W,Lai Y,Yu T,Chen QK

更新日期：2019-04-01 00:00:00

abstract：:Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex....

journal_title：Journal of pharmacological sciences

authors： Nakayama H,Yamakuni H,Nakayama A,Maeda Y,Imazumi K,Matsuo M,Mutoh S

更新日期：2004-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:The effect of T-2328 {2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK(1)-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. Cisplatin induced acute emesis in 24 h and delayed emesis during 24 and 72 h, ...

journal_title：Journal of pharmacological sciences

authors： Watanabe Y,Okamoto M,Ishii T,Takatsuka S,Taniguchi H,Nagasaki M,Saito A

更新日期：2008-06-01 00:00:00

abstract：:System L (SL), a basolateral amino acid transporter, transports large neutral amino acids (LNAAs) in a Na(+)-independent manner. Previously, we identified two isoforms of transporters: L-type amino acid transporter 1 (LAT1) and 2 (LAT2) and revealed their distinct substrate selectivity and transport properties. In thi...

journal_title：Journal of pharmacological sciences

authors： Morimoto E,Kanai Y,Kim DK,Chairoungdua A,Choi HW,Wempe MF,Anzai N,Endou H

更新日期：2008-12-01 00:00:00

abstract：:There is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam...

journal_title：Journal of pharmacological sciences

authors： Joskova M,Durdik P,Sutovska M,Grendar M,Koniar D,Hargas L,Banovcin P,Franova S

更新日期：2020-04-01 00:00:00

abstract：:Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, performs immunomodulatory activity on cancer patients suffering from radiotherapy or chemotherapy. The present study aims to investigate the anti-hepatocellular carcinoma effects of CSEI in cells and tumor-xenografted mouse models. In HepG2...

journal_title：Journal of pharmacological sciences

authors： Jia D,Lu W,Zhang X,Cai G,Teng L,Wang X,Zhang M,Zeng Y,Liang C,Wang D

更新日期：2016-10-01 00:00:00

abstract：:The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social...

journal_title：Journal of pharmacological sciences

authors： Nakashima MN,Ajiki K,Nakashima K,Takahashi M

更新日期：2003-01-01 00:00:00