Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice.

Abstract:

:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intravitreal injection of NMDA in the retinas of mice. An intravitreal injection of NMDA induced neuronal cell death in both the retinal ganglion cell layer and inner nuclear layer, and reduced the amplitudes of scotopic threshold response (STR) in electroretinography studies. Both cell death and STR amplitudes decrease induced by NMDA were prevented by a co-injection of [Pyr1]-apelin-13, and were facilitated by apelin deficiency. The neuroprotective effects of [Pyr1]-apelin-13 were blocked by an apelin receptor APJ antagonist, and by inhibitors of Akt and extracellular signal-regulated kinase 1/2 signaling pathways. Additionally, an intravitreal injection of tumor necrosis factor-α (TNF-α) neutralizing antibody prevented NMDA-induced retinal neuronal cell death, and exogenous and endogenous apelin suppressed NMDA-induced upregulation of TNF-α in the retina. These results suggest that apelin protects neuronal cells against NMDA-induced death via an APJ receptor in the retina, and that apelin may have beneficial effects in the treatment of glaucoma.

journal_name

J Pharmacol Sci

authors

Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

doi

10.1016/j.jphs.2016.12.002

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

34-41

issue

1

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(16)30170-0

journal_volume

133

pub_type

杂志文章
  • Involvement of histamine released from mast cells in acute radiation dermatitis in mice.

    abstract::A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.sc0070127

    authors: Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

    更新日期:2007-06-01 00:00:00

  • Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia.

    abstract::Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges. Therefore, there is an urgent need to develop more effective targeted therapies. The receptor tyrosine kinase C-KIT confers critical prolifer...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2018.12.010

    authors: Ma W,Xiang Y,Yang R,Zhang T,Xu J,Wu Y,Liu X,Xiang K,Zhao H,Liu Y,Si Y

    更新日期:2019-04-01 00:00:00

  • Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells.

    abstract::Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracel...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2019.03.008

    authors: Horinouchi T,Karki S,Terada K,Mazaki Y,Miwa S

    更新日期:2019-05-01 00:00:00

  • Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor.

    abstract::The GABAergic system in the spinal cord has been shown to participate in neuropathic pain in various animal models. GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; however, their role in neuropathic pain remains unclear. In the present study, we compared the betaine/GABA transporter...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.13146fp

    authors: Jinzenji A,Sogawa C,Miyawaki T,Wen XF,Yi D,Ohyama K,Kitayama S,Sogawa N,Morita K

    更新日期:2014-01-01 00:00:00

  • Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs.

    abstract::Incomplete recovery of myocardial contraction after reperfusion following brief ischemia is called the "stunning phenomenon" in an animal experiment. A hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) does not affect this phenomenon, but lipophilic statins further reduce the con...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.08017fp

    authors: Satoh K,Takaguri A,Itagaki M,Kano S,Ichihara K

    更新日期:2008-04-01 00:00:00

  • The effect of antioxidant on development of fibrosis by cisplatin in rats.

    abstract::Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.09185fp

    authors: Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

    更新日期:2009-12-01 00:00:00

  • Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor.

    abstract::Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2018.12.005

    authors: Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

    更新日期:2019-02-01 00:00:00

  • Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury.

    abstract::Reactive oxygen species have been known as important contributors to ischemia/reperfusion (I/R) injury. Studies on the beneficial effect of N-acetylcysteine (NAC), a potent antioxidant, on limiting infarct size induced by I/R yielded contrasting results. The present study was undertaken to compare the effect of NAC by...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.fp0071664

    authors: Abe M,Takiguchi Y,Ichimaru S,Tsuchiya K,Wada K

    更新日期:2008-04-01 00:00:00

  • Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model.

    abstract::There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that de...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2020.02.011

    authors: Saito Y,Nakamura S,Chinen N,Shimazawa M,Hara H

    更新日期:2020-06-01 00:00:00

  • Lifestyle-related diseases of the digestive system: a new in vitro model of hepatitis C virion production: application of basic research on hepatitis C virus to clinical medicine.

    abstract::The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1254/jphs.fm0070040

    authors: Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

    更新日期:2007-10-01 00:00:00

  • P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.

    abstract::P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.14050fp

    authors: Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

    更新日期:2014-01-01 00:00:00

  • Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

    abstract::To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin signifi...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2017.12.008

    authors: He WB,Abe K,Akaishi T

    更新日期:2018-01-01 00:00:00

  • Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.

    abstract::Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1254/jphs.91.187

    authors: Shinozaki K,Kashiwagi A,Masada M,Okamura T

    更新日期:2003-03-01 00:00:00

  • Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference.

    abstract::In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced pla...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.11201fp

    authors: Shibasaki M,Kurokawa K,Mizuno K,Ohkuma S

    更新日期:2012-01-01 00:00:00

  • Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.

    abstract::Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O2(-)) generation in the insulin-resistant state. We investigated the effects of atorvastatin, a 3-hydroxyl-3-methylglutaryl coenzyme A (HMG CoA) reductase...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.13178fp

    authors: Okamura T,Tawa M,Geddawy A,Shimosato T,Iwasaki H,Shintaku H,Yoshida Y,Masada M,Shinozaki K,Imamura T

    更新日期:2014-01-01 00:00:00

  • The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.

    abstract::Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (< or = 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model....

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.fpj04038x

    authors: Satoh Y,Sugiyama A,Takahara A,Ando K,Wang K,Honsho S,Hashimoto K

    更新日期:2005-01-01 00:00:00

  • Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats.

    abstract::Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2014.12.001

    authors: Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

    更新日期:2015-03-01 00:00:00

  • Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.08167sc

    authors: Orido T,Fujino H,Hasegawa Y,Toyomura K,Kawashima T,Murayama T

    更新日期:2008-11-01 00:00:00

  • New topics in vasopressin receptors and approach to novel drugs: involvement of vasopressin V1a and V1b receptors in nociceptive responses and morphine-induced effects.

    abstract::Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1254/jphs.08r30fm

    authors: Honda K,Takano Y

    更新日期:2009-01-01 00:00:00

  • Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.

    abstract::Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by amino acid transporters upregulated in tumor cells. Here, by using ...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jphs.2019.01.012

    authors: Miyabe J,Ohgaki R,Saito K,Wei L,Quan L,Jin C,Liu X,Okuda S,Nagamori S,Ohki H,Yoshino K,Inohara H,Kanai Y

    更新日期:2019-03-01 00:00:00

  • QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation.

    abstract::To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.qt-c13

    authors: Kano M,Toyoshi T,Iwasaki S,Kato M,Shimizu M,Ota T

    更新日期:2005-01-01 00:00:00

  • Characteristics of attenuating effects of rebamipide, an anti-ulcer agent, on oxidative burst of human neutrophils.

    abstract::The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimul...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.91.153

    authors: Shimoyama T,Fukuda S,Liu Q,Fukuda Y,Nakaji S,Sugawara K

    更新日期:2003-02-01 00:00:00

  • Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.

    abstract::L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.12003fp

    authors: Inden M,Abe M,Minamino H,Takata K,Yoshimoto K,Tooyama I,Kitamura Y

    更新日期:2012-01-01 00:00:00

  • New approaches to blockade of the renin-angiotensin-aldosterone system: overview of regulation of the renin-angiotensin-aldosterone system.

    abstract::The critical role played by the renin-angiotensin-aldosterone system (RAAS) in the regulation of blood pressure and body fluid homeostasis has been well recognized. Angiotensin (Ang) II and aldosterone are the most powerful biologically active products of the RAAS, although there are also other bioactive Ang peptides ...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1254/jphs.10r03fm

    authors: Nishiyama A,Kim-Mitsuyama S

    更新日期:2010-01-01 00:00:00

  • Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.

    abstract::This study examined the effects of baicalin, a bioactive flavonoid isolated from Scutellariae Radix, on carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl(4) and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl(4) tr...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.fp0071392

    authors: Park SW,Lee CH,Kim YS,Kang SS,Jeon SJ,Son KH,Lee SM

    更新日期:2008-01-01 00:00:00

  • Effect of cigarette smoke components on vascular smooth muscle cell migration toward platelet-derived growth factor BB.

    abstract::Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h preincubation of GBaSM-4 VSMCs with nicotine or nicotine-free cigarette...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.10283sc

    authors: Yoshiyama S,Horinouchi T,Miwa S,Wang HH,Kohama K,Nakamura A

    更新日期:2011-01-01 00:00:00

  • Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.

    abstract::The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.92.245

    authors: Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

    更新日期:2003-07-01 00:00:00

  • Multiple mechanisms for the action of chymase inhibitors.

    abstract::Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.1254/jphs.11r11cp

    authors: Takai S,Jin D,Miyazaki M

    更新日期:2012-01-01 00:00:00

  • Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.

    abstract::Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO)...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章

    doi:10.1254/jphs.10136sc

    authors: Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara K

    更新日期:2010-01-01 00:00:00

  • Enhanced expression of glutathione S-transferase in the hippocampus following acute treatment with trimethyltin in vivo.

    abstract::We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. ...

    journal_title:Journal of pharmacological sciences

    pub_type: 历史文章,杂志文章

    doi:10.1254/jphs.09158sc

    authors: Nagashima R,Sano S,Huong NQ,Shiba T,Ogita K

    更新日期:2010-01-01 00:00:00