Abstract:
:Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice. The three-drug combined treatment displayed a potent synergistic antinociceptive effect, together with a significant reduction of gastrointestinal transit inhibition. Furthermore, selective µ- and κ-opioid receptor antagonists reversed these synergistic antinociceptive effects, thus suggesting a pivotal role of the opioid system. Overall, this study presents accurate pre-clinical data that might be useful to improve the clinical management of opioid-mediated analgesia.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Fernández-Dueñas V,Poveda R,Sánchez S,Ciruela Fdoi
10.1254/jphs.11161scsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
299-302issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/11161SCjournal_volume
118pub_type
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