当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland.

Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland.

Abstract：

:Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide. Moreover, mRNA expression of PBR and pituitary adenylate cyclase-activating polypeptide (PACAP), a transcriptional regulator for DBI promoter, was evaluated after repetitive administration of DZP. Repetitive administration, but not single administration, of 0.4 mg/kg DZP caused inhibition of salivary secretion and enhanced expression of DBI, PACAP, and PBR mRNA in rat salivary gland, with an increase in production of DBI peptide. These results suggest that repetitive administration of DZP stimulates DBI production, which may result in an increase in the suppressive effect of DZP on salivary secretion.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Tsukagoshi E,Kawaguchi M,Shinomiya T,Yoshikawa M,Kawano T,Okubo M,Sawaki K

doi

10.1254/jphs.10282FP

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

221-229

issue

2

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(19)30788-1

journal_volume

115

pub_type

杂志文章

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