Enhanced expression of glutathione S-transferase in the hippocampus following acute treatment with trimethyltin in vivo.

abstract：:The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

journal_title：Journal of pharmacological sciences

authors： Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

更新日期：2007-10-01 00:00:00

abstract：:Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Na(v)) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Na(v), using voltage-clamp techniques in Xenopus oocytes expressed ...

journal_title：Journal of pharmacological sciences

authors： Horishita T,Ueno S,Yanagihara N,Sudo Y,Uezono Y,Okura D,Sata T

更新日期：2012-01-01 00:00:00

abstract：:By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in the cytosolic space with no staining in the nucleus, whereas acetylch...

journal_title：Journal of pharmacological sciences

authors： Chiba Y,Uchida T,Sakai H,Oku T,Itoh S,Tsuji T,Misawa M

更新日期：2004-08-01 00:00:00

abstract：:Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abuse, criminal involvement, and suicide. To address this issue, milnacip...

journal_title：Journal of pharmacological sciences

authors： Tsutsui-Kimura I,Ohmura Y,Yoshida T,Yoshioka M

更新日期：2017-07-01 00:00:00

abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

journal_title：Journal of pharmacological sciences

authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

更新日期：2014-01-01 00:00:00

abstract：:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells duri...

journal_title：Journal of pharmacological sciences

authors： Takahashi-Yanaga F,Sasaguri T

更新日期：2007-08-01 00:00:00

abstract：:A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over ...

journal_title：Journal of pharmacological sciences

authors： Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

更新日期：2005-07-01 00:00:00

abstract：:A novel AMP-activated protein kinase (AMPK) activator, IMM-H007 (H007), has been reported to reduce serum lipid levels and inhibit lipid accumulation in the liver in hyperlipidemic animal models. However, how H007 ameliorates hepatic steatosis and inflammation remains unknown. In the present study, H007, at 200 mg/kg,...

journal_title：Journal of pharmacological sciences

authors： Peng X,Li J,Wang M,Qu K,Zhu H

更新日期：2019-06-01 00:00:00

abstract：:Type 2 diabetes (T2D) and obesity are important public health problems. The global prevalence of diabetes mellitus is 8.8%. Interventional diabetology and obesitology have been recently advocated as treatment options for T2D and obesity. The roles of metabolic surgery such as Roux-en-Y gastric bypass, sleeve gastrecto...

journal_title：Journal of pharmacological sciences

authors： Syu YF,Inui A,Chen CY

更新日期：2017-02-01 00:00:00

abstract：:The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (-UE) rat detrusor strips pretreated with K+-channel blockers wer...

journal_title：Journal of pharmacological sciences

authors： Hidayat Santoso AG,Liang W

更新日期：2011-01-01 00:00:00

abstract：:The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day) for 4 days. NG-nit...

journal_title：Journal of pharmacological sciences

authors： Shiga S,Machida T,Yanada T,Machida M,Hirafuji M,Iizuka K

更新日期：2020-05-01 00:00:00

abstract：:We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-HT2 receptor antagonist on the discriminative stimulus effects o...

journal_title：Journal of pharmacological sciences

authors： Yoshizawa K,Mori T,Ueno T,Nishiwaki M,Shibasaki M,Shimizu N,Narita M,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Schisandra chinensis is a hepatoprotective herb that has been used for centuries in China. Polysaccharide is one of the major active components in S. chinensis, which has been reported to improve liver injuries induced by carbon tetrachloride, alcohol, or high-fat diet. In this study, we observed the effects and corre...

journal_title：Journal of pharmacological sciences

authors： Che J,Yang S,Qiao Z,Li H,Sun J,Zhuang W,Chen J,Wang C

更新日期：2019-07-01 00:00:00

abstract：:Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

journal_title：Journal of pharmacological sciences

authors： Honda K,Takano Y

更新日期：2009-01-01 00:00:00

abstract：:Serum prolactin levels were investigated in 41 patients with schizophrenia who were receiving clinically effective doses of perospirone or risperidone for more than 4 weeks. In order to determine baseline prolactin levels, blood samples were obtained in the morning, 10 - 14 h after antipsychotic medication. Median lev...

journal_title：Journal of pharmacological sciences

authors： Togo T,Iseki E,Shoji M,Oyama I,Kase A,Uchikado H,Katsuse O,Kosaka K

更新日期：2003-03-01 00:00:00

abstract：:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reare...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda T

更新日期：2012-01-01 00:00:00

abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

journal_title：Journal of pharmacological sciences

authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

更新日期：2019-07-01 00:00:00

abstract：:Re-expression of fetal genes has been considered to underlie ionic remodeling in diseased heart. T-type Ca(2+) channels have been reported to be functionally expressed in embryonic hearts. In this review, we summarize developmental changes of T-type Ca(2+) channels in mouse ventricles from 9.5 days postcoitum (dpc) to...

journal_title：Journal of pharmacological sciences

authors： Yasui K,Niwa N,Takemura H,Opthof T,Muto T,Horiba M,Shimizu A,Lee JK,Honjo H,Kamiya K,Kodama I

更新日期：2005-11-01 00:00:00

abstract：:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesi...

journal_title：Journal of pharmacological sciences

authors： Satoh M,Takayanagi I

更新日期：2006-01-01 00:00:00

abstract：:The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl)adenosine (2-CN-Ado) selectively bound to the A(2a) receptor with a...

journal_title：Journal of pharmacological sciences

authors： Konno T,Murakami A,Uchibori T,Nagai A,Kogi K,Nakahata N

更新日期：2005-04-01 00:00:00

abstract：:We investigated the roles of β- and α(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol,...

journal_title：Journal of pharmacological sciences

authors： Deyama S,Takishita A,Tanimoto S,Ide S,Nakagawa T,Satoh M,Minami M

更新日期：2010-01-01 00:00:00

abstract：:IAP antagonists increased the antitumor efficacy of X-irradiation in some types of cancers, but their effects on hypoxic cancer cells remain unclarified. We aims to investigate the radiosensitizing effect of an IAP inhibitor AT-406 on cervical cancer cell lines under both normoxia and hypoxia conditions. Hela and Siha...

journal_title：Journal of pharmacological sciences

authors： Lu J,Qin Q,Zhan LL,Liu J,Zhu HC,Yang X,Zhang C,Xu LP,Liu ZM,Wang D,Cui HQ,Meng CC,Cai J,Cheng HY,Sun XC

更新日期：2014-01-01 00:00:00

abstract：:Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage geno...

journal_title：Journal of pharmacological sciences

authors： Takahashi K,Nishizawa D,Kasai S,Koukita Y,Fukuda KI,Ichinohe T,Ikeda K

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to investigated the possi...

journal_title：Journal of pharmacological sciences

authors： Xiang C,Yan Y,Zhang D

更新日期：2021-01-01 00:00:00

abstract：:This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-88...

journal_title：Journal of pharmacological sciences

authors： Kuraishi Y,Ohtsuka E,Nakano T,Kawai S,Andoh T,Nojima H,Kamimura K

更新日期：2007-09-01 00:00:00

abstract：:In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced pla...

journal_title：Journal of pharmacological sciences

authors： Shibasaki M,Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-01-01 00:00:00

abstract：:Our previous study showed that organobismuth compounds induce apoptosis in human promyelocytic leukemia cells, although solid tumor cell lines were relatively resistant. Herein, we investigated the primary cellular target of these compounds in HeLa cells. One organobismuth compound, bi-chlorodibenzo[c,f][1,5]thiabismo...

journal_title：Journal of pharmacological sciences

authors： Iuchi K,Akagi K,Yagura T

更新日期：2009-04-01 00:00:00

abstract：:Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in h...

journal_title：Journal of pharmacological sciences

authors： Noguchi K,Matsuzaki T,Sakanashi M,Hamadate N,Uchida T,Kina-Tanada M,Kubota H,Nakasone J,Sakanashi M,Ueda S,Masuzaki H,Ishiuchi S,Ohya Y,Tsutsui M

更新日期：2015-02-01 00:00:00

abstract：:In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the prot...

journal_title：Journal of pharmacological sciences

authors： Jung YS,Jung YS,Kim MY,Kim MH,Lee S,Yi KY,Yoo SE,Lee SH,Baik EJ,Moon CH,Cho JP

更新日期：2003-05-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZD) compounds. [3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfony...

journal_title：Journal of pharmacological sciences

authors： Fujimura T,Sakuma H,Konishi S,Oe T,Hosogai N,Kimura C,Aramori I,Mutoh S

更新日期：2005-12-01 00:00:00