The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.

abstract：:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...

journal_title：Journal of pharmacological sciences

authors： Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

更新日期：2019-02-01 00:00:00

abstract：:Effects of V(1) (OPC-21268) and V(2) (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at ...

journal_title：Journal of pharmacological sciences

authors： Japundzić-Zigon N,Milutinović S,Jovanović A

更新日期：2004-05-01 00:00:00

abstract：:Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA...

journal_title：Journal of pharmacological sciences

authors： Babu E,Takeda M,Nishida R,Noshiro-Kofuji R,Yoshida M,Ueda S,Fukutomi T,Anzai N,Endou H

更新日期：2010-01-01 00:00:00

abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

journal_title：Journal of pharmacological sciences

authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

更新日期：2007-06-01 00:00:00

abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

journal_title：Journal of pharmacological sciences

authors： Takai S,Jin D,Miyazaki M

更新日期：2012-01-01 00:00:00

abstract：:To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...

journal_title：Journal of pharmacological sciences

authors： Kano M,Toyoshi T,Iwasaki S,Kato M,Shimizu M,Ota T

更新日期：2005-01-01 00:00:00

abstract：:Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (< or = 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model....

journal_title：Journal of pharmacological sciences

authors： Satoh Y,Sugiyama A,Takahara A,Ando K,Wang K,Honsho S,Hashimoto K

更新日期：2005-01-01 00:00:00

abstract：:The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...

journal_title：Journal of pharmacological sciences

authors： Ohsawa M,Kamei J

更新日期：2005-05-01 00:00:00

abstract：:Although cyclic ADP-ribose (cADPR), a novel Ca(2+)-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear. The present study examined the ability of cADPR to mobilize Ca(2+) and mediate formyl methionyl leucyl phenylalanine (fMLP)-stim...

journal_title：Journal of pharmacological sciences

authors： Morita K,Saida M,Morioka N,Kitayama T,Akagawa Y,Dohi T

更新日期：2008-03-01 00:00:00

abstract：:Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detai...

journal_title：Journal of pharmacological sciences

authors： Kaundal RK,Iyer S,Kumar A,Sharma SS

更新日期：2009-03-01 00:00:00

abstract：:Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we inves...

journal_title：Journal of pharmacological sciences

authors： Kurauchi Y,Noma K,Hisatsune A,Seki T,Katsuki H

更新日期：2018-11-01 00:00:00

abstract：:In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that...

journal_title：Journal of pharmacological sciences

authors： Hu J,Geng M,Li J,Xin X,Wang J,Tang M,Zhang J,Zhang X,Ding J

更新日期：2004-06-01 00:00:00

abstract：:By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in the cytosolic space with no staining in the nucleus, whereas acetylch...

journal_title：Journal of pharmacological sciences

authors： Chiba Y,Uchida T,Sakai H,Oku T,Itoh S,Tsuji T,Misawa M

更新日期：2004-08-01 00:00:00

abstract：:Dopamine (DA) has been suggested to modulate functions of glial cells including microglial cells. To reveal the regulatory role of DA in microglial function, in the present study, we investigated the effect of DA on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine microglial cell line BV-2. Pret...

journal_title：Journal of pharmacological sciences

authors： Yoshioka Y,Sugino Y,Tozawa A,Yamamuro A,Kasai A,Ishimaru Y,Maeda S

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caff...

journal_title：Journal of pharmacological sciences

authors： Yoshihara T,Zaitsu M,Shiraishi F,Arima H,Takahashi-Yanaga F,Arioka M,Kajioka S,Sasaguri T

更新日期：2019-03-01 00:00:00

abstract：:IAP antagonists increased the antitumor efficacy of X-irradiation in some types of cancers, but their effects on hypoxic cancer cells remain unclarified. We aims to investigate the radiosensitizing effect of an IAP inhibitor AT-406 on cervical cancer cell lines under both normoxia and hypoxia conditions. Hela and Siha...

journal_title：Journal of pharmacological sciences

authors： Lu J,Qin Q,Zhan LL,Liu J,Zhu HC,Yang X,Zhang C,Xu LP,Liu ZM,Wang D,Cui HQ,Meng CC,Cai J,Cheng HY,Sun XC

更新日期：2014-01-01 00:00:00

abstract：:Selegiline is used an adjunct to L-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with L-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. L-DOPA 0 (3 h), 1...

journal_title：Journal of pharmacological sciences

authors： Adachi K,Miwa H,Kusumoto H,Shimazu S,Kondo T

更新日期：2006-08-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an evolving cancer treatment with promising results in treating malignant tumors by photoactivation of a photosensitizer with a specific wavelength. The second generation photosensitizer mono-L-aspartyl chlorin e6 (NPe6) was reported to have significant efficacy in killing cancer cells in...

journal_title：Journal of pharmacological sciences

authors： Wong TW,Aizawa K,Sheyhedin I,Wushur C,Kato H

更新日期：2003-10-01 00:00:00

abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

更新日期：2013-01-01 00:00:00

abstract：:Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg...

journal_title：Journal of pharmacological sciences

authors： Tsutsumi K,Kaname T,Shiraishi H,Kawashiri T,Egashira N

更新日期：2016-06-01 00:00:00

abstract：:Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal sacral dorsal commissural nucleus neurons. In the present study,...

journal_title：Journal of pharmacological sciences

authors： Yamaga T,Aou S,Shin MC,Wakita M,Akaike N

更新日期：2012-01-01 00:00:00

abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

journal_title：Journal of pharmacological sciences

authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

更新日期：2016-03-01 00:00:00

abstract：:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesi...

journal_title：Journal of pharmacological sciences

authors： Satoh M,Takayanagi I

更新日期：2006-01-01 00:00:00

abstract：:Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice. The three-drug combined treatment displayed a pote...

journal_title：Journal of pharmacological sciences

authors： Fernández-Dueñas V,Poveda R,Sánchez S,Ciruela F

更新日期：2012-01-01 00:00:00

abstract：:Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, an...

journal_title：Journal of pharmacological sciences

authors： Matsuoka S

更新日期：2004-09-01 00:00:00

abstract：:Glucocorticoids are stress hormones released from the adrenal cortex and their concentration is controlled by the hypothalamic-pituitary-adrenal axis. In this study, we investigated the effect of glucocorticoids on the number of astrocytes and glucocorticoid receptor (GR) expression in vitro and in vivo. Proliferation...

journal_title：Journal of pharmacological sciences

authors： Unemura K,Kume T,Kondo M,Maeda Y,Izumi Y,Akaike A

更新日期：2012-01-01 00:00:00

abstract：:Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated. We investigated the therapeutic effects of melittin on muscle in...

journal_title：Journal of pharmacological sciences

authors： Lee JE,Shah VK,Lee EJ,Oh MS,Choi JJ

更新日期：2019-05-01 00:00:00

abstract：:Cytochrome P450 (CYP)-mediated drug interactions caused by Kampo medicine have not been investigated sufficiently. The current study was conducted to reveal the effect of anchusan, a commonly used Kampo formula for gastrointestinal disease, on CYP3A-mediated drug metabolism in rats. The pharmacokinetics of midazolam (...

journal_title：Journal of pharmacological sciences

authors： Saito Y,Nishimura Y,Kurata N,Iwase M,Aoki K,Yasuhara H

更新日期：2011-01-01 00:00:00

abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

journal_title：Journal of pharmacological sciences

authors： Thunyakitpisal PD,Chaisuparat R

更新日期：2004-04-01 00:00:00

abstract：:Luminal hydrogen sulfide (H(2)S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca(2+) channels. Here we analyzed the mechanisms for H(2)S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H(2)S donor, evoked visceral ...

journal_title：Journal of pharmacological sciences

authors： Tsubota-Matsunami M,Noguchi Y,Okawa Y,Sekiguchi F,Kawabata A

更新日期：2012-01-01 00:00:00