Abstract:
:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing-induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda Tdoi
10.1254/jphs.11200scsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
295-8issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/11200SCjournal_volume
118pub_type
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