Abstract:
:The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, NG-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) depressed tension developed (Td) and also aminophylline-induced potentiation of Td in a concentration-dependent manner. Verapamil (2.5 microM) or nicardipine (20 microM) significantly antagonized the potentiating effect of L-NAME on Td in a calcium-containing medium. However, in the presence of verapamil or nicardipine, L-NAME still produced statistically significant potentiation of the cumulative concentrations of aminophylline (0.36 - 3.60 mM), given in the second series.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Stojanovic R,Todorović Z,Nesić Z,Vućković S,Cerovac-Cosić N,Prostran Mdoi
10.1254/jphs.sce04001xsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
493-8issue
4eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/SCE04001Xjournal_volume
96pub_type
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