Effects of propofol on electrocardiogram measures in mice.

abstract：:The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, NG-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) de...

journal_title：Journal of pharmacological sciences

authors： Stojanovic R,Todorović Z,Nesić Z,Vućković S,Cerovac-Cosić N,Prostran M

更新日期：2004-12-01 00:00:00

abstract：:We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

journal_title：Journal of pharmacological sciences

authors： Goto T,Tomizawa N,Kobayashi E,Fujimura A

更新日期：2004-06-01 00:00:00

abstract：:We have shown that coadministration of sulpiride and fluvoxamine preferentially increases the release of dopamine in the prefrontal cortex. To study the possible role of the cortical cholinergic system in this effect, we combined several other antipsychotic drugs with fluvoxamine and examined the effects on acetylchol...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Sato M,Nakamura S,Baba A,Matsuda T

更新日期：2006-12-01 00:00:00

abstract：:Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we inves...

journal_title：Journal of pharmacological sciences

authors： Kurauchi Y,Noma K,Hisatsune A,Seki T,Katsuki H

更新日期：2018-11-01 00:00:00

abstract：:Intrathecal (i.t.) administration of D-cycloserine (100 and 300 fmol), a partial agonist of the glycine recognition site on the N-methyl-D-aspartate (NMDA) receptor ion-channel complex, produced a behavioral response mainly consisting of biting and/or licking of the hindpaw and the tail along with slight hindlimb scra...

journal_title：Journal of pharmacological sciences

authors： Tan-No K,Esashi A,Nakagawasai O,Niijima F,Furuta S,Sato T,Satoh S,Yasuhara H,Tadano T

更新日期：2007-05-01 00:00:00

abstract：:Serum prolactin levels were investigated in 41 patients with schizophrenia who were receiving clinically effective doses of perospirone or risperidone for more than 4 weeks. In order to determine baseline prolactin levels, blood samples were obtained in the morning, 10 - 14 h after antipsychotic medication. Median lev...

journal_title：Journal of pharmacological sciences

authors： Togo T,Iseki E,Shoji M,Oyama I,Kase A,Uchikado H,Katsuse O,Kosaka K

更新日期：2003-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

journal_title：Journal of pharmacological sciences

authors： Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

更新日期：2007-10-01 00:00:00

abstract：:Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex....

journal_title：Journal of pharmacological sciences

authors： Nakayama H,Yamakuni H,Nakayama A,Maeda Y,Imazumi K,Matsuo M,Mutoh S

更新日期：2004-11-01 00:00:00

abstract：:Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC staining ratio was strongest in L929 cells. 3-Methyladenine...

journal_title：Journal of pharmacological sciences

authors： Yu J,Li X,Tashiro S,Onodera S,Ikejima T

更新日期：2008-07-01 00:00:00

abstract：:In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes. A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(2+) (Ca(2+)(i)) in freshly isolate...

journal_title：Journal of pharmacological sciences

authors： Tanaka R,Muraki K,Ohya S,Yamamura H,Hatano N,Itoh Y,Imaizumi Y

更新日期：2008-10-01 00:00:00

abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

journal_title：Journal of pharmacological sciences

authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

更新日期：2007-06-01 00:00:00

abstract：:In canine ventricular myocardium, endothelin-1 (ET-1) alone induced only a weak transient negative inotropic effect (NIE). However, ET-1 induced a marked sustained positive inotropic effect (PIE) subsequent to a transient NIE in the presence of norepinephrine (NE) at low concentrations (0.1 - 1 nM) and elicited a pron...

journal_title：Journal of pharmacological sciences

authors： Chu L,Zhang JX,Norota I,Endoh M

更新日期：2005-03-01 00:00:00

abstract：:Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly in...

journal_title：Journal of pharmacological sciences

authors： Inoue H,Aihara M,Tomioka M,Watabe Y

更新日期：2013-01-01 00:00:00

abstract：:Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fi...

journal_title：Journal of pharmacological sciences

authors： Nah SS,Ha E,Mun SH,Won HJ,Chung JH

更新日期：2008-01-01 00:00:00

abstract：:Mithramycin A (MTM) has been shown to inhibit cancer growth by blocking the binding of Sp-family transcription factors to gene regulatory elements and is used for the treatment of leukemia and testicular cancer in the United States. In contrast, MTM has also been shown to exert neuroprotective effects in normal cells....

journal_title：Journal of pharmacological sciences

authors： Osada N,Kosuge Y,Ishige K,Ito Y

更新日期：2013-01-01 00:00:00

abstract：:The involvement of Ca2+ entry via the Na+/Ca2+ exchanger (NCX) in myogenic constriction of rat posterior cerebral arteries was investigated. RT-PCR identified mRNA for NCX1, 2, and 3 in the arteries. Na+ removal increased [Ca2+]i, which was reduced by the NCX inhibitor SEA0400. SEA0400 inhibited the development, but n...

journal_title：Journal of pharmacological sciences

authors： Kashihara T,Nakayama K,Matsuda T,Baba A,Ishikawa T

更新日期：2009-06-01 00:00:00

abstract：:NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade. NQ12 concentration-dependently suppressed collagen-, AA-, and U46619-i...

journal_title：Journal of pharmacological sciences

authors： Jin YR,Han XH,Lee JJ,Lim Y,Kim TJ,Yoo HS,Hong JT,Lee CK,Yun YP

更新日期：2007-10-01 00:00:00

abstract：:Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in h...

journal_title：Journal of pharmacological sciences

authors： Noguchi K,Matsuzaki T,Sakanashi M,Hamadate N,Uchida T,Kina-Tanada M,Kubota H,Nakasone J,Sakanashi M,Ueda S,Masuzaki H,Ishiuchi S,Ohya Y,Tsutsui M

更新日期：2015-02-01 00:00:00

abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

journal_title：Journal of pharmacological sciences

authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

更新日期：2014-01-01 00:00:00

abstract：:Nicotine inhibited interleukin (IL)-18 and -12 production in lipopolysaccharide (LPS)-stimulated monocytes, and the action of nicotine was antagonized by a non-selective and a selective alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) antagonist, suggesting that the stimulation of alpha7-nAChR may be involved in...

journal_title：Journal of pharmacological sciences

authors： Takahashi HK,Iwagaki H,Hamano R,Yoshino T,Tanaka N,Nishibori M

更新日期：2006-09-01 00:00:00

abstract：:A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over ...

journal_title：Journal of pharmacological sciences

authors： Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

更新日期：2005-07-01 00:00:00

abstract：:Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed in the glandular stomach via administration of histamine (40 mg/...

journal_title：Journal of pharmacological sciences

authors： Amagase K,Okabe S

更新日期：2003-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as elevation of mean pulmonary arterial pressure to ≥25 mmHg within the low pressure pulmonary circulatory system. PAH is characterized by obstructive vascular remodeling, partially due to excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Puerarin i...

journal_title：Journal of pharmacological sciences

authors： Zhang X,Liu Q,Zhang C,Sheng J,Li S,Li W,Yang X,Wang X,He S,Bai J,Zhu D

更新日期：2019-10-01 00:00:00

abstract：:The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social...

journal_title：Journal of pharmacological sciences

authors： Nakashima MN,Ajiki K,Nakashima K,Takahashi M

更新日期：2003-01-01 00:00:00

abstract：:Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, an...

journal_title：Journal of pharmacological sciences

authors： Matsuoka S

更新日期：2004-09-01 00:00:00

abstract：:Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), hig...

journal_title：Journal of pharmacological sciences

authors： Kawaguchi H,Miyoshi N,Miura N,Fujiki M,Horiuchi M,Izumi Y,Miyajima H,Nagata R,Misumi K,Takeuchi T,Tanimoto A,Yoshida H

更新日期：2011-01-01 00:00:00

abstract：:This study was undertaken to identify novel approaches to pharmacological treatment of asthma. Here we hypothesize that the platelet-activating factor receptor antagonist ginkgolide B (GB) in combination with the antioxidant carotenoid astaxanthin (ASX) suppresses T cell activation comparably to two commonly-used anti...

journal_title：Journal of pharmacological sciences

authors： Mahmoud FF,Haines DD,Abul HT,Abal AT,Onadeko BO,Wise JA

更新日期：2004-02-01 00:00:00

abstract：:Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagoni...

journal_title：Journal of pharmacological sciences

authors： Shin EJ,Jeong JH,Chung YH,Kim TW,Shin CY,Kim WK,Ko KH,Kim HC

更新日期：2009-07-01 00:00:00

abstract：:This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-88...

journal_title：Journal of pharmacological sciences

authors： Kuraishi Y,Ohtsuka E,Nakano T,Kawai S,Andoh T,Nojima H,Kamimura K

更新日期：2007-09-01 00:00:00