Abstract:
:The involvement of Ca2+ entry via the Na+/Ca2+ exchanger (NCX) in myogenic constriction of rat posterior cerebral arteries was investigated. RT-PCR identified mRNA for NCX1, 2, and 3 in the arteries. Na+ removal increased [Ca2+]i, which was reduced by the NCX inhibitor SEA0400. SEA0400 inhibited the development, but not the steady-state, of pressure-induced myogenic constriction, whereas it decreased both the initial and sustained phases of [Ca2+]i elevation. These results suggest that Ca2+ entry via NCX is involved in the development, but not the steady-state, of pressure-induced myogenic constriction.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Kashihara T,Nakayama K,Matsuda T,Baba A,Ishikawa Tdoi
10.1254/jphs.09054scsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
218-22issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/09054SCjournal_volume
110pub_type
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