Abstract:
:Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Shin EJ,Jeong JH,Chung YH,Kim TW,Shin CY,Kim WK,Ko KH,Kim HCdoi
10.1254/jphs.09015scsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
401-4issue
3eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/09015SCjournal_volume
110pub_type
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