Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:To examine effects of volatile anesthetics (VAs) on steroidogenesis, cell suspensions of isolated bovine adrenocortical cells were incubated with several steroidogenic agents in the presence or absence of halothane and sevoflurane. The adrenocortical cells were dispersed by trypsin digestion of bovine adrenal cortex. ...

journal_title：Journal of pharmacological sciences

authors： Masaki E,Shoji K,Saito H,Yamazaki K,Kawamura M

更新日期：2003-10-01 00:00:00

abstract：:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells duri...

journal_title：Journal of pharmacological sciences

authors： Takahashi-Yanaga F,Sasaguri T

更新日期：2007-08-01 00:00:00

abstract：:In conventional relative gene expression analysis (Northern blotting, RT-PCR, and in situ hybridization), housekeeping genes such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin genes, whose expression levels are considered stable, have been used as control genes for normalization of RNA quantit...

journal_title：Journal of pharmacological sciences

authors： Nishida Y,Sugahara-Kobayashi M,Takahashi Y,Nagata T,Ishikawa K,Asai S

更新日期：2006-05-01 00:00:00

abstract：:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...

journal_title：Journal of pharmacological sciences

authors： Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

更新日期：2019-02-01 00:00:00

abstract：:L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...

journal_title：Journal of pharmacological sciences

authors： Inden M,Abe M,Minamino H,Takata K,Yoshimoto K,Tooyama I,Kitamura Y

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as elevation of mean pulmonary arterial pressure to ≥25 mmHg within the low pressure pulmonary circulatory system. PAH is characterized by obstructive vascular remodeling, partially due to excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Puerarin i...

journal_title：Journal of pharmacological sciences

authors： Zhang X,Liu Q,Zhang C,Sheng J,Li S,Li W,Yang X,Wang X,He S,Bai J,Zhu D

更新日期：2019-10-01 00:00:00

abstract：:Mood disorders are not merely attributed to the functional defect of neurotransmission, but also are due to the structural impairment of neuroplasticity. Chronic stress decreases neurotrophin levels, precipitating or exacerbating depression; conversely, antidepressants increase expression of various neurotrophins (e.g...

journal_title：Journal of pharmacological sciences

authors： Wada A

更新日期：2009-05-01 00:00:00

abstract：:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, sig...

journal_title：Journal of pharmacological sciences

authors： Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

更新日期：2010-01-01 00:00:00

abstract：:In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscles of rats for electroen...

journal_title：Journal of pharmacological sciences

authors： Takeda Y,Ishida T,Tsutsui R,Toide K,Tanimoto-Mori S,Watanabe S,Kanai Y,Kamei C

更新日期：2008-07-01 00:00:00

abstract：:Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for...

journal_title：Journal of pharmacological sciences

authors： Yamaguchi T,Yamazaki T,Kawaguchi H,Tawa M,Nakamura Y,Shiota M,Osada-Oka M,Tanimoto A,Okamura T,Miura K,Iwao H,Yoshiyama M,Izumi Y

更新日期：2014-01-01 00:00:00

abstract：:We characterized the effects of vanadate, an inhibitor of tyrosine phosphatase, on the tension, the level of myosin light chain (MLC) phosphorylation, and Rho A activation in intact ileal longitudinal smooth muscle of the guinea pig to study the role of tyrosine phosphorylation in contraction signaling. Vanadate exert...

journal_title：Journal of pharmacological sciences

authors： Mori M,Tsushima H

更新日期：2004-08-01 00:00:00

abstract：:In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced pla...

journal_title：Journal of pharmacological sciences

authors： Shibasaki M,Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-01-01 00:00:00

abstract：:Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta release. In this study, we further investigated signaling events involved in oridonin-augmented phagocytos...

journal_title：Journal of pharmacological sciences

authors： Liu YQ,You S,Tashiro S,Onodera S,Ikejima T

更新日期：2005-08-01 00:00:00

abstract：:Heat shock protein 90 (HSP90) antagonists are currently being evaluated as potential anticancer drugs. However, adverse effects related to these drugs, such as fatigue and pain, suggest that they affect neurons. Therefore, to understand the influence of HSP90 inhibitors on neurons, we investigated the effects of gelda...

journal_title：Journal of pharmacological sciences

authors： Migita K,Matsumoto T,Terada K,Ono K,Hara S

更新日期：2019-07-01 00:00:00

abstract：:Serum prolactin levels were investigated in 41 patients with schizophrenia who were receiving clinically effective doses of perospirone or risperidone for more than 4 weeks. In order to determine baseline prolactin levels, blood samples were obtained in the morning, 10 - 14 h after antipsychotic medication. Median lev...

journal_title：Journal of pharmacological sciences

authors： Togo T,Iseki E,Shoji M,Oyama I,Kase A,Uchikado H,Katsuse O,Kosaka K

更新日期：2003-03-01 00:00:00

abstract：:The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the intestinal tissue a...

journal_title：Journal of pharmacological sciences

authors： Takano Y,Hirano M,Machida T,Obara Y,Hamaue N,Fujita K,Taniguchi M,Endo T,Shiga S,Machida M,Iizuka K,Hirafuji M

更新日期：2019-09-01 00:00:00

abstract：:A number of patients with hyperlipidemia are prescribed 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that are concomitantly used along with the treatment of diabetes mellitus. The effects of atorvastatin and pravastatin on insulin-induced glucose uptake and the related signal transduction in 3T3L1 adipocytes we...

journal_title：Journal of pharmacological sciences

authors： Takaguri A,Satoh K,Itagaki M,Tokumitsu Y,Ichihara K

更新日期：2008-05-01 00:00:00

abstract：:Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals. Nonetheless, whether other histamine H(2)-receptor antagonists exert such tumor suppressive effects remains unclear. The effect of roxatidine acetate hydrochloride (roxatidine), an H(2)-receptor anta...

journal_title：Journal of pharmacological sciences

authors： Tomita K,Izumi K,Okabe S

更新日期：2003-11-01 00:00:00

abstract：:Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity...

journal_title：Journal of pharmacological sciences

authors： Baba S,Enomoto T,Horisawa T,Hashimoto T,Ono M

更新日期：2015-03-01 00:00:00

abstract：:A novel AMP-activated protein kinase (AMPK) activator, IMM-H007 (H007), has been reported to reduce serum lipid levels and inhibit lipid accumulation in the liver in hyperlipidemic animal models. However, how H007 ameliorates hepatic steatosis and inflammation remains unknown. In the present study, H007, at 200 mg/kg,...

journal_title：Journal of pharmacological sciences

authors： Peng X,Li J,Wang M,Qu K,Zhu H

更新日期：2019-06-01 00:00:00

abstract：:Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

journal_title：Journal of pharmacological sciences

authors： Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

更新日期：2009-12-01 00:00:00

abstract：:Our previous study showed that organobismuth compounds induce apoptosis in human promyelocytic leukemia cells, although solid tumor cell lines were relatively resistant. Herein, we investigated the primary cellular target of these compounds in HeLa cells. One organobismuth compound, bi-chlorodibenzo[c,f][1,5]thiabismo...

journal_title：Journal of pharmacological sciences

authors： Iuchi K,Akagi K,Yagura T

更新日期：2009-04-01 00:00:00

abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

更新日期：2013-01-01 00:00:00

abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

journal_title：Journal of pharmacological sciences

authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

更新日期：2014-01-01 00:00:00

abstract：:Circulating endothelial progenitor cells (EPCs) derived from bone marrow were isolated for the first time in 1997 and characterized. Recent evidence has indicated that EPCs contribute to re-endothelialization of injured vessels as well as neovascularization of ischemic lesions and that a decrease in the number of EPCs...

journal_title：Journal of pharmacological sciences

authors： Umemura T,Higashi Y

更新日期：2008-09-01 00:00:00

abstract：:The critical role played by the renin-angiotensin-aldosterone system (RAAS) in the regulation of blood pressure and body fluid homeostasis has been well recognized. Angiotensin (Ang) II and aldosterone are the most powerful biologically active products of the RAAS, although there are also other bioactive Ang peptides ...

journal_title：Journal of pharmacological sciences

authors： Nishiyama A,Kim-Mitsuyama S

更新日期：2010-01-01 00:00:00

abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

journal_title：Journal of pharmacological sciences

authors： Takai S,Jin D,Miyazaki M

更新日期：2012-01-01 00:00:00

abstract：:Reactive oxygen species have been known as important contributors to ischemia/reperfusion (I/R) injury. Studies on the beneficial effect of N-acetylcysteine (NAC), a potent antioxidant, on limiting infarct size induced by I/R yielded contrasting results. The present study was undertaken to compare the effect of NAC by...

journal_title：Journal of pharmacological sciences

authors： Abe M,Takiguchi Y,Ichimaru S,Tsuchiya K,Wada K

更新日期：2008-04-01 00:00:00

abstract：:We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h after the administration. The P...

journal_title：Journal of pharmacological sciences

authors： Tsubota M,Ozaki T,Hayashi Y,Okawa Y,Fujimura A,Sekiguchi F,Nishikawa H,Kawabata A

更新日期：2018-01-01 00:00:00