Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.

abstract：:Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug that can potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance, a disorder that induces urticaria, asthma, and anaphylaxis in response to oral administration of the dr...

journal_title：Journal of pharmacological sciences

authors： Suzuki Y,Ra C

更新日期：2009-07-01 00:00:00

abstract：:The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-r...

journal_title：Journal of pharmacological sciences

authors： Fujimori K,Takaki J,Shigemoto-Mogami Y,Sekino Y,Suzuki T,Sato K

更新日期：2015-01-01 00:00:00

abstract：:The mechanisms of action of acupuncture and moxibustion as reported by Japanese researchers are reviewed. The endogenous opioid-mediated mechanisms of electroacupuncture (EA) as used in China are well understood, but these are only one component of all mechanisms of acupuncture. These studies emphasize the similarity ...

journal_title：Journal of pharmacological sciences

authors： Kawakita K,Shinbara H,Imai K,Fukuda F,Yano T,Kuriyama K

更新日期：2006-01-01 00:00:00

abstract：:Glucocorticoids are stress hormones released from the adrenal cortex and their concentration is controlled by the hypothalamic-pituitary-adrenal axis. In this study, we investigated the effect of glucocorticoids on the number of astrocytes and glucocorticoid receptor (GR) expression in vitro and in vivo. Proliferation...

journal_title：Journal of pharmacological sciences

authors： Unemura K,Kume T,Kondo M,Maeda Y,Izumi Y,Akaike A

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca(2+) entry (ROCE) triggered by activation of endothelin type A receptor (ET(A)R) and to clarify the importance of calmodulin (CaM) / inositol 1,4,5-trisphosphate (IP(3)) receptor binding ...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Terada K,Higa T,Aoyagi H,Nishiya T,Suzuki H,Miwa S

更新日期：2011-01-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. It has been reported that testosterone represses 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced transcription of the cytochrome P450 (CYP) ...

journal_title：Journal of pharmacological sciences

authors： Sanada N,Gotoh Y,Shimazawa R,Klinge CM,Kizu R

更新日期：2009-03-01 00:00:00

abstract：:To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...

journal_title：Journal of pharmacological sciences

authors： Kano M,Toyoshi T,Iwasaki S,Kato M,Shimizu M,Ota T

更新日期：2005-01-01 00:00:00

abstract：:Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

journal_title：Journal of pharmacological sciences

authors： Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

更新日期：2009-12-01 00:00:00

abstract：:In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscles of rats for electroen...

journal_title：Journal of pharmacological sciences

authors： Takeda Y,Ishida T,Tsutsui R,Toide K,Tanimoto-Mori S,Watanabe S,Kanai Y,Kamei C

更新日期：2008-07-01 00:00:00

abstract：:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

journal_title：Journal of pharmacological sciences

authors： Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

更新日期：2015-03-01 00:00:00

abstract：:In the novel object recognition task, ZSET1446 (also coded as ST101) enhanced object recognition memory in mice and ameliorated cognitive impairment caused by scopolamine in rats. The enhancement induced by ZSET1446 in mice was abolished by injection of mechamylamine, a nonselective antagonist of nicotinic acetylcholi...

journal_title：Journal of pharmacological sciences

authors： Yamaguchi Y,Takeda K,Hino M

更新日期：2013-01-01 00:00:00

abstract：:We investigated whether endothelin (ET) would be involved in skin cancer pain in mice. Orthotopic inoculation of B16-BL6 melanoma cells into the plantar region of the hind paw produced marked mechanical allodynia in C57BL/6 mice. Intraplantar injections of the ET(A)-receptor antagonist BQ-123 (0.3 - 3 nmol/site), but ...

journal_title：Journal of pharmacological sciences

authors： Fujita M,Andoh T,Saiki I,Kuraishi Y

更新日期：2008-02-01 00:00:00

abstract：:We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3, morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer cells via suppression of the Wnt/beta-catenin signaling pathway. However, the target molecules of DIFs involved in the anti-proliferative effects...

journal_title：Journal of pharmacological sciences

authors： Matsuda T,Takahashi-Yanaga F,Yoshihara T,Maenaka K,Watanabe Y,Miwa Y,Morimoto S,Kubohara Y,Hirata M,Sasaguri T

更新日期：2010-01-01 00:00:00

abstract：:We recently reported that physiological concentrations of 17beta-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K(+) currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17beta-estradiol, we investigated r...

journal_title：Journal of pharmacological sciences

authors： Kakusaka S,Asayama M,Kaihara A,Sasano T,Suzuki T,Kurokawa J,Furukawa T

更新日期：2009-01-01 00:00:00

abstract：:Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, performs immunomodulatory activity on cancer patients suffering from radiotherapy or chemotherapy. The present study aims to investigate the anti-hepatocellular carcinoma effects of CSEI in cells and tumor-xenografted mouse models. In HepG2...

journal_title：Journal of pharmacological sciences

authors： Jia D,Lu W,Zhang X,Cai G,Teng L,Wang X,Zhang M,Zeng Y,Liang C,Wang D

更新日期：2016-10-01 00:00:00

abstract：:Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Our molecular docking results showed that entecavir as a P2X7R antagonist interacted perfectly with the human P2X7R (...

journal_title：Journal of pharmacological sciences

authors： Ming Y,Xin G,Ji B,Ji C,Wei Z,Zhang B,Zhang J,Yu K,Zhang X,Li S,Li Y,Xing Z,Niu H,Huang W

更新日期：2020-09-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by inflammation, multifocal fibrotic lesions and excessive collagen deposition with limited therapies. As a major bioactive compound in garlic, S-allyl-l-cysteine (SAC) is a neuroprotective drug candidate to prevent cognitive de...

journal_title：Journal of pharmacological sciences

authors： Nie Y,Yu K,Li B,Hu Y,Zhang H,Xin R,Xiong Y,Zhao P,Chai G

更新日期：2019-04-01 00:00:00

abstract：:Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracel...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Karki S,Terada K,Mazaki Y,Miwa S

更新日期：2019-05-01 00:00:00

abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

journal_title：Journal of pharmacological sciences

authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

更新日期：2019-07-01 00:00:00

abstract：:Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we inves...

journal_title：Journal of pharmacological sciences

authors： Kurauchi Y,Noma K,Hisatsune A,Seki T,Katsuki H

更新日期：2018-11-01 00:00:00

abstract：:Mood disorders are not merely attributed to the functional defect of neurotransmission, but also are due to the structural impairment of neuroplasticity. Chronic stress decreases neurotrophin levels, precipitating or exacerbating depression; conversely, antidepressants increase expression of various neurotrophins (e.g...

journal_title：Journal of pharmacological sciences

authors： Wada A

更新日期：2009-05-01 00:00:00

abstract：:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-b...

journal_title：Journal of pharmacological sciences

authors： Saito H

更新日期：2008-03-01 00:00:00

abstract：:In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes. A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(2+) (Ca(2+)(i)) in freshly isolate...

journal_title：Journal of pharmacological sciences

authors： Tanaka R,Muraki K,Ohya S,Yamamura H,Hatano N,Itoh Y,Imaizumi Y

更新日期：2008-10-01 00:00:00

abstract：:Clinically, hemorrhoidal bleeding and prolapse disappeared immediately after injection of the sclerosing agent OC-108 into submucosa of hemorrhoids. The aim of this study was to elucidate the mechanism of action responsible for the immediate hemostatic effect of OC-108 using anesthetized rats. Subcutaneous injection o...

journal_title：Journal of pharmacological sciences

authors： Ono T,Nakagawa H,Fukunari A,Hashimoto T,Komatsu H

更新日期：2006-11-01 00:00:00

abstract：:Effects of V(1) (OPC-21268) and V(2) (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at ...

journal_title：Journal of pharmacological sciences

authors： Japundzić-Zigon N,Milutinović S,Jovanović A

更新日期：2004-05-01 00:00:00

abstract：:We studied the effects of antipsychotics and a hypnotic on sleep disturbance in schizophrenia using an animal model of the disease. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were chronically implanted into the cortex and the dorsal neck muscle of rats. EEG and EMG were recorded with an ele...

journal_title：Journal of pharmacological sciences

authors： Ishida T,Obara Y,Kamei C

更新日期：2009-09-01 00:00:00

abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

journal_title：Journal of pharmacological sciences

authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

更新日期：2007-06-01 00:00:00

abstract：:Mithramycin A (MTM) has been shown to inhibit cancer growth by blocking the binding of Sp-family transcription factors to gene regulatory elements and is used for the treatment of leukemia and testicular cancer in the United States. In contrast, MTM has also been shown to exert neuroprotective effects in normal cells....

journal_title：Journal of pharmacological sciences

authors： Osada N,Kosuge Y,Ishige K,Ito Y

更新日期：2013-01-01 00:00:00

abstract：:The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...

journal_title：Journal of pharmacological sciences

authors： Ohsawa M,Kamei J

更新日期：2005-05-01 00:00:00