Abstract:
:Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA-II inhibited organic anion uptake by hOAT1, hOAT3, and hOAT4 in dose-dependent manners. Treatment of hOAT3 with AA-I resulted in a significant reduction in viability compared with that of mock, which was rescued by the organic anion transport inhibitor probenecid. In conclusion, hOAT3-mediated AA-I uptake may be associated with the induction of nephrotoxicity.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Babu E,Takeda M,Nishida R,Noshiro-Kofuji R,Yoshida M,Ueda S,Fukutomi T,Anzai N,Endou Hdoi
10.1254/jphs.09339scsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
192-6issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/09339SCjournal_volume
113pub_type
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