Abstract：
:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non-alcoholic fatty liver disease (NAFLD) caused by fat accumulation, we administrated OEA or fenofibrate in Sprague Dawley (SD) rats fed with a high fat diet (HFD). After 6 or 17 weeks treatment, OEA (5 mg/kg/day, i.p.) relieved the development of NAFLD compared with control groups by regulating the levels of plasma TG, TC, ALT and AST and liver inflammatory cytokines. Gene expression analysis of liver tissue and plasma from the animal models showed that OEA and fenofibrate both promoted the lipid β-oxidation by activating PPAR-α. Detailed research revealed that OEA inhibited the mRNA expression of lipogenesis in a PPAR-α-independant manner, while fenofibrate expressed an opposite effection. In summary, our research results suggested that as a potential lead compound, OEA could improve HFD-induced NAFLD with higher efficacy and safety than fenofibrate.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Ydoi
10.1016/j.jphs.2014.12.001subject
Has Abstractpub_date
2015-03-01 00:00:00pages
244-50issue
3eissn
1347-8613issn
1347-8648pii
S1347-8613(14)00018-8journal_volume
127pub_type
杂志文章abstract：:Selegiline is used an adjunct to L-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with L-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. L-DOPA 0 (3 h), 1...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0051085
更新日期：2006-08-01 00:00:00
abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2016.12.002
更新日期：2017-01-01 00:00:00
abstract：:Photodynamic therapy (PDT) is an evolving cancer treatment with promising results in treating malignant tumors by photoactivation of a photosensitizer with a specific wavelength. The second generation photosensitizer mono-L-aspartyl chlorin e6 (NPe6) was reported to have significant efficacy in killing cancer cells in...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.93.136
更新日期：2003-10-01 00:00:00
abstract：:This study was undertaken to evaluate the differences in chronotherapeutic effects of angiotensin-II receptor blockers, valsartan and olmesartan in hypertensive patients with non-dipper blood pressure (BP) pattern during valsartan at morning. Ninety four patients were enrolled, and 40 patients were judged to be non-di...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jphs.2014.09.004
更新日期：2015-01-01 00:00:00
abstract：:In conventional relative gene expression analysis (Northern blotting, RT-PCR, and in situ hybridization), housekeeping genes such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin genes, whose expression levels are considered stable, have been used as control genes for normalization of RNA quantit...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0050881
更新日期：2006-05-01 00:00:00
abstract：:Yeasts isolated from patients with superficial mycoses were tested against propolis samples collected from different regions and honeybee races. The minimum inhibitory concentration (MIC) values obtained using the agar dilution methods were compared to the diameters of growth inhibition zones by using the disk diffusi...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fpe05002x
更新日期：2005-09-01 00:00:00
abstract：:The effects of AS1892802, a selective Rho-associated coiled coil kinase (ROCK) inhibitor, on knee cartilage damage and pain behavior were examined in a rat model of osteoarthritis (OA). Monoiodoacetate (MIA) was intraarticularly injected into the right knee joints of rats. ROCK I and II mRNA levels increased in knee j...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.10319fp
更新日期：2011-01-01 00:00:00
abstract：:Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, an...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.fmj04002x2
更新日期：2004-09-01 00:00:00
abstract：:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2018.12.005
更新日期：2019-02-01 00:00:00
abstract：:Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagoni...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.09015sc
更新日期：2009-07-01 00:00:00
abstract：:NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade. NQ12 concentration-dependently suppressed collagen-, AA-, and U46619-i...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0071006
更新日期：2007-10-01 00:00:00
abstract：:Aggressive tumor growth and diffuse tissue invasion are hallmarks of malignant glioma. Embelin is an active compound identified as a novel XIAP inhibitor from the Embelia ribes that exhibits various medicinal effects including anti-inflammatory and anti-cancer activities. In the present study, we investigated whether ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.12137fp
更新日期：2013-01-01 00:00:00
abstract：:We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study. Repeated treatment with imipramine at concentrations of 1 - 10 microM for 5 days inh...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.92.433
更新日期：2003-08-01 00:00:00
abstract：:We aimed to examine the rate of thrombotic events after discontinuation of one year clopidogrel therapy in patients with implanted coronary stent, and to determine platelet aggregability by multiple electrode analyzer after cessation of clopidogrel. This prospective, multicenter study enrolled 200 patients subjected t...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.11076fp
更新日期：2011-01-01 00:00:00
abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.11r11cp
更新日期：2012-01-01 00:00:00
abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.14050fp
更新日期：2014-01-01 00:00:00
abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2016.07.010
更新日期：2016-10-01 00:00:00
abstract：:Many kinds of vasodilators induce relaxation of the vascular smooth muscle cells (VSMCs) through the production of cyclic AMP (cAMP) or cyclic GMP (cGMP). The relaxant effects mediated by these second messengers are thought to be mainly due to the decrease in intracellular Ca(2+) concentration ([Ca(2+)](i)), as well a...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.fmj06002x5
更新日期：2006-09-01 00:00:00
abstract：:The involvement of Ca2+ entry via the Na+/Ca2+ exchanger (NCX) in myogenic constriction of rat posterior cerebral arteries was investigated. RT-PCR identified mRNA for NCX1, 2, and 3 in the arteries. Na+ removal increased [Ca2+]i, which was reduced by the NCX inhibitor SEA0400. SEA0400 inhibited the development, but n...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.09054sc
更新日期：2009-06-01 00:00:00
abstract：:In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced pla...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.11201fp
更新日期：2012-01-01 00:00:00
abstract：:Circulating levels of calcium ion (Ca(2+)) are maintained within a narrow physiological range mainly by the action of parathyroid hormone (PTH) secreted from parathyroid cells. Parathyroid cells can sense small fluctuations in plasma Ca(2+) levels by virtue of a cell surface Ca(2+) receptor (CaR) that belongs to the s...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.fmj04007x6
更新日期：2005-03-01 00:00:00
abstract：:Ca(2+) release from intracellular store sites via the ryanodine receptor (RyR) and hormonal regulation by flutamide, an androgen-receptor (AR) antagonist, on it were examined in vas deferens (VD) smooth muscle cells (SMCs). VD and VDSMCs were obtained from two groups of male rats that were treated p.o. with 100 mg/kg ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.09037fp
更新日期：2009-05-01 00:00:00
abstract：:Incomplete recovery of myocardial contraction after reperfusion following brief ischemia is called the "stunning phenomenon" in an animal experiment. A hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) does not affect this phenomenon, but lipophilic statins further reduce the con...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.08017fp
更新日期：2008-04-01 00:00:00
abstract：:It has been shown that enhancement of vasoconstrictor prostanoids plays an important role in the development of cardiovascular diseases. The aim of the present study was to examine the effects of pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant and a potent inhibitor of nuclear factor-kappa...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.09116fp
更新日期：2009-07-01 00:00:00
abstract：:L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.12003fp
更新日期：2012-01-01 00:00:00
abstract：:Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage geno...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2018.02.002
更新日期：2018-03-01 00:00:00
abstract：:N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal cell death. We hypothesized that nitric oxide synthase (NOS)/NO are in...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2015.02.008
更新日期：2015-03-01 00:00:00
abstract：:In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fpj04004x
更新日期：2004-06-01 00:00:00
abstract：:Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence of rivaroxaban on cardiac remodeling caused by intermittent hypoxia (IH). Male C5...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2018.07.002
更新日期：2018-07-01 00:00:00
abstract：:Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed in the glandular stomach via administration of histamine (40 mg/...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.92.124
更新日期：2003-06-01 00:00:00
