Abstract:
CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern during the last years; especially considering the neurologic system. RESULTS:However, we have evidence that there is some concern regarding their effects on the liver cells. Fortunately not all the anesthetics are blamed and even some could be used safely, based on the available evidence. CONCLUSIONS:Besides, there are some novel agents, yet under research, which could affect the future of anesthetic agents' fate regarding their hepatic effects.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Dabbagh A,Rajaei Sdoi
10.5812/hepatmon.13162subject
Has Abstractpub_date
2013-08-25 00:00:00pages
e13162issue
8eissn
1735-143Xissn
1735-3408journal_volume
13pub_type
杂志文章,评审abstract:BACKGROUND:Reversibility of advanced fibrosis after HCV-clearance is an important goal of therapy. OBJECTIVES:Measuring liver stiffness (LS) by transient elastography (TE) might be helpful in this setting. PATIENTS AND METHODS:We evaluated 104 patients with biopsy-proven chronic hepatitis C (CHC) and sustained virolo...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7176
更新日期:2013-05-11 00:00:00
abstract:BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31906
更新日期:2015-11-28 00:00:00
abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7359
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. OBJECTIVES:The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.806
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.37447
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarker...
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更新日期:2013-06-16 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...
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pub_type: 杂志文章
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更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11447
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.17822
更新日期:2014-06-08 00:00:00
abstract:BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...
journal_title:Hepatitis monthly
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更新日期:2016-06-28 00:00:00
abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Zinc deficiency has been reported frequently in hepatitis C patients in the literature. Furthermore, a decrease in zinc level has been shown in beta thalassemia major as well. Iranians consume a large amount of phytate in their regimens which can bind with zinc and decrease its gastrointestinal absorption. ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11138
更新日期:2013-08-12 00:00:00
abstract:BACKGROUND:In spite of dozens of clinical trials to establish effective therapeutic and/or preventive vaccine to resolve HCV infection, no real vaccine has been proved to date. Genetic vaccines based on replication-defective adenoviruses have proved to elicit strong and long lasting T-cell responses against a number of...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.6130
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.9611
更新日期:2013-05-30 00:00:00
abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.38726
更新日期:2016-12-14 00:00:00
abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.8340
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.40492
更新日期:2016-10-02 00:00:00
abstract:BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15(5)2015.28473
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.22649
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.789
更新日期:2011-12-01 00:00:00
abstract::Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) an...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. OBJECTIVES:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. PATIENTS AN...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.33710
更新日期:2015-12-28 00:00:00
abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.24635
更新日期:2014-12-24 00:00:00
abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.40357
更新日期:2016-08-23 00:00:00
abstract:BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15900
更新日期:2014-02-25 00:00:00
abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10813
更新日期:2014-08-17 00:00:00
abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31490
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:Chronic hepatitis C (CHC) is a global infection. In Saudi Arabia, the prevalence of CHC is declining due to the implementation of a blood screening program. However, CHC still remains a leading cause of liver cirrhosis and hepatocellular carcinoma. OBJECTIVES:This is a retrospective study of CHC patients at...
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doi:10.5812/hepatmon.6178
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...
journal_title:Hepatitis monthly
pub_type:
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更新日期:2016-10-30 00:00:00
abstract:BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.34266
更新日期:2016-03-05 00:00:00