Fibrosis evaluation by transient elastography in patients with long-term sustained HCV clearance.


BACKGROUND:Reversibility of advanced fibrosis after HCV-clearance is an important goal of therapy. OBJECTIVES:Measuring liver stiffness (LS) by transient elastography (TE) might be helpful in this setting. PATIENTS AND METHODS:We evaluated 104 patients with biopsy-proven chronic hepatitis C (CHC) and sustained virological response (SVR) after Peg-Interferon (IFN) plus ribavirin since at least 18 months. HCV-eradication was confirmed searching for serum HCV-RNA (TMA® sensitivity > 5-10 IU/ml). Data from literature reported the best LS cut-off values for different stages of liver fibrosis were 7.1 kPa for Metavir stage 2 (F2), 9.5 kPa for F3 and 12.5 for cirrhosis (F4). RESULTS:TE was not reliable in four SVR obese patients. Metavir-stage of biopsy was F0-1 in 28, F2 in 47, F3 in 17 and F4 in eight patients. The median interval elapsed since achieving SVR was 36 months (range: 18-77, SD¬¬:18). Stratifying patients according to the histological stage assessed before treatment, a clear-cut gradient of LS values was observed from F0-1: median: 3.8 kPa (range: 3.5-4.9) to F2: 4.6 kPa (3.8-6.0), F3: 6.2 kPa (4.8-8.6) and F4: 8.4 kPa (6.2-9.2) (P = 0.001). Overall, 86 patients had lower values of LS than the expected LS values according to Metavir-stage. At multivariate logistic analysis γ-GT and histological steatosis were independently associated with persistence of higher values of LS. CONCLUSION:Long term responders to IFN-based therapies have lower LS values than those who are untreated and still viraemic. High levels of γ-GT and liver steatosis, all markers of insulin resistance, may hamper reduction of liver stiffness after HCV-clearance.


Hepat Mon


Hepatitis monthly


Calvaruso V,Di Marco V,Ferraro D,Petta S,Calì A,Grazia Bavetta M,Conte E,Luigi Almasio P




Has Abstract


2013-05-11 00:00:00












  • Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography: Fibroscan in inactive HBsAg carriers.

    abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Sporea I,Nicolita D,Sirli R,Deleanu A,Tudora A,Bota S

    更新日期:2011-03-01 00:00:00

  • Egy-score predicts severe hepatic fibrosis and cirrhosis in Egyptians with chronic liver diseases: a pilot study.

    abstract:BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarker...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Alboraie MA,Afifi ME,Elghamry FG,Shalaby HA,Elshennawy GE,Abdelaziz AA,Shaheen MU,Abo El-Seoud AR

    更新日期:2013-06-16 00:00:00

  • Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran.

    abstract:BACKGROUND:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. OBJECTIVES:The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Amin-Esmaeili M,Rahimi-Movaghar A,Razaghi EM,Baghestani AR,Jafari S

    更新日期:2012-01-01 00:00:00

  • Analysis of T Cell Receptor Vβ Diversity in Peripheral CD4+ and CD8+ T Lymphocytes Obtained From Patients With Chronic Severe Hepatitis B.

    abstract:BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Xiong Y,Tan Y,Song YG

    更新日期:2014-02-25 00:00:00

  • Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran.

    abstract:BACKGROUND:Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES:To determine the prevalence of HBV infections and risk factors for the disease for the first time in B...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Ziaee M,Ebrahimzadeh A,Azarkar Z,Namaei MH,Saburi A,Fereidouni M,Bijari B,Karamian M,Sharifzadeh G

    更新日期:2016-08-14 00:00:00

  • The Correlation Between Interferon Lambda 3 Gene Polymorphisms and Susceptibility to Hepatitis B Virus Infection.

    abstract:BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Heidari Z,Moudi B,Mahmoudzadeh-Sagheb H,Hashemi M

    更新日期:2016-03-05 00:00:00

  • Evaluation of prevalence and risk factors of hepatitis g virus infection among hemodialysis patients referred to Iranian army hospitals in tehran during 2012-2013.

    abstract:BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Dadmanesh M,Hosseinzadeh M,Keyvani H,Ghorban K,Rahimi M,Hosseinzadeh M,Ranjbar MM

    更新日期:2015-01-01 00:00:00

  • A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan.

    abstract:BACKGROUND:Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. OBJECTIVES:To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world. PATIENTS AND METHODS:We conducted a prosp...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Mumtaz K,Hamid S,Ahmed S,Moatter T,Mushtaq S,Khan A,Mizokami M,Jafri W

    更新日期:2011-01-01 00:00:00

  • Hepatitis C in Pakistan: a review of available data.

    abstract::Hepatitis C virus (HCV) infection is increasingly recognized as a major health care problem, and is found frequently in Pakistani settings. In this article we reviewed published and unpublished data related to the seroepidemiology of HCV infection in Pakistan. For this article, data from 132 published studies and thre...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Umar M,Bushra HT,Ahmad M,Data A,Ahmad M,Khurram M,Usman S,Arif M,Adam T,Minhas Z,Arif A,Naeem A,Ejaz K,Butt Z,Bilal M

    更新日期:2010-07-01 00:00:00

  • Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis.

    abstract:BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Rezaee R,Poorebrahim M,Najafi S,Sadeghi S,Pourdast A,Alavian SM,Alavian SE,Poortahmasebi V

    更新日期:2016-06-28 00:00:00

  • Vaccination Against Hepatitis A for Hemophilic Patients: Is It Necessary?

    abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Mirzaei J,Ziaee M,Farsad SA,Fereydooni M,Anani Sarab G,Rezvani Khorashad MR

    更新日期:2016-04-05 00:00:00

  • Persistence of HBV Vaccine's Protection and Response to Hepatitis B Booster Immunization in 5- to 7-Year-Old Children in the Kohgiloyeh and Boyerahmad Province, Iran.

    abstract:BACKGROUND AND AIMS:The duration of the protection of hepatitis B vaccination for infants and the necessity of a booster dose administration is unknown. The aim of the present study was to evaluate the persistence of seroprotection after hepatitis B virus (HBV) vaccination in order to determine the necessity of a singl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Yazdanpanah B,Safari M,Yazdanpanah S

    更新日期:2010-01-01 00:00:00

  • Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes.

    abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Minosse C,Coen S,Visco Comandini U,Lionetti R,Montalbano M,Cerilli S,Vincenti D,Baiocchini A,Capobianchi MR,Menzo S

    更新日期:2016-02-29 00:00:00

  • Evaluating Liver Fibrosis by Transient Elastometry in Patients With HIV-HCV Coinfection and Monoinfection.

    abstract:BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Brescini L,Orsetti E,Gesuita R,Piraccini F,Marchionni E,Staffolani S,Castelli P,Drenaggi D,Barchiesi F

    更新日期:2014-08-05 00:00:00

  • LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes.

    abstract:BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Liu Y,Zou Z,Zhu B,Hu Z,Zeng P,Wu L

    更新日期:2015-05-23 00:00:00

  • Chronic hepatitis C in saudi arabia: three years local experience in a university hospital.

    abstract:BACKGROUND:Chronic hepatitis C (CHC) is a global infection. In Saudi Arabia, the prevalence of CHC is declining due to the implementation of a blood screening program. However, CHC still remains a leading cause of liver cirrhosis and hepatocellular carcinoma. OBJECTIVES:This is a retrospective study of CHC patients at...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Akbar HO,Al Ghamdi A,Qattan F,Fallatah HI,Al Rumani M

    更新日期:2012-09-01 00:00:00

  • Trends in the Incidence Rates of Chronic Hepatitis B in Poland in the Years 2005 - 2013.

    abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Stawinska-Witoszynska B,Zysnarska M,Krzywinska-Wiewiorowska M,Wojtyła-Buciorab P,Krzyzaniak A,Wieckowska B

    更新日期:2016-07-25 00:00:00

  • Sequencing and Phylogenetic Study of Partial NS3 Gene of Iranian GB Virus C/Hepatitis G Virus (HGV) Originated From Hemodialysis Patients in Tehran.

    abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Dadmanesh M,Ranjbar MM,Alavian SM,Ghorban K

    更新日期:2015-03-05 00:00:00

  • The role of anesthetic drugs in liver apoptosis.

    abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审


    authors: Dabbagh A,Rajaei S

    更新日期:2013-08-25 00:00:00

  • Hepatitis B vaccination in chronic kidney disease: review of evidence in non-dialyzed patients.

    abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Grzegorzewska AE

    更新日期:2012-11-01 00:00:00

  • Interferon alpha-2b therapy in chronic hepatitis delta.

    abstract:BACKGROUND:Approximately 5% of hepatitis B virus (HBV) carriers are coinfected with hepatitis D virus (HDV). HBV/HDV coinfection is a major cause of cirrhosis and end stage liver disease in chronic HBsAg carriers. The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or c...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Keshvari M,Alavian SM,Sharafi H,Karimi G,Gholami Fesharaki M

    更新日期:2014-03-01 00:00:00

  • Low Serum Hepatitis B Surface Antigen Level Predicts Compensated Cirrhosis Caused by Chronic Hepatitis B in HBeAg Positive Patients in East China.

    abstract:BACKGROUNDS:Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection. OBJECTIVES:The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients. PATIENTS AN...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Jia W,Qi X,Ji YY,Xun YH,Wang H,Zhang WH,Yang JH,Wang JY,Zhu HX,Mao RC,Zhang JM

    更新日期:2015-08-30 00:00:00

  • Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.

    abstract:BACKGROUND:There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production. OBJECTIVES:To investigate the potential association of two polymorphisms ( 137G/C a...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Wu L,Chen L,Zhou L,Xie H,Wei B,Yin S,Ye Y,Fang W,Zheng S

    更新日期:2011-06-01 00:00:00

  • Decrease of serum Angiotensin converting enzyme levels upon telbivudine treatment for chronic hepatitis B virus infection and negative correlations between the enzyme levels and estimated glumerular filtration rates.

    abstract:BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Liang KH,Chen YC,Hsu CW,Chang ML,Yeh CT

    更新日期:2014-01-31 00:00:00

  • Biliary Intraepithelial Neoplasia (BilIN) in Primary Sclerosing Cholangitis: The First Report from Iran.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Akbarzadeh L,Geramizadeh B,Kazemi K,Nikeghbalian S,Malekhosseini S

    更新日期:2016-12-14 00:00:00

  • The Distribution of Hepatitis C Virus Genotypes in Middle Eastern Countries: A Systematic Review and Meta-Analysis.

    abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审


    authors: Ghaderi-Zefrehi H,Gholami-Fesharaki M,Sharafi H,Sadeghi F,Alavian SM

    更新日期:2016-08-23 00:00:00

  • Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology.

    abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Rostami Z,Lessan Pezeshki M,Soleimani Najaf Abadi A,Einollahi B

    更新日期:2013-05-30 00:00:00

  • Liver storage disease in Iran: a ten year study of liver biopsies in Children Medical Center Hospital in Tehran-Iran.

    abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Motamed F,Monajemzadeh M,Seifirad S,Ashrafi M,Rasti A,Mahjoub F

    更新日期:2011-08-01 00:00:00

  • HCV NS3 Blocking Effect on IFN Induced ISGs Like Viperin and IL28 With and Without NS4A.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Khanlari Z,Sabahi F,Hosseini SY,Ghaderi M

    更新日期:2014-06-08 00:00:00

  • The Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study.

    abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Sharafi H,Alavian SM,Behnava B,Pouryasin A,Keshvari M

    更新日期:2014-10-01 00:00:00