Abstract:
BACKGROUND:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. OBJECTIVES:The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran. PATIENTS AND METHODS:A cross-sectional study included 899 IDUs recruited from the community, drug treatment centers, and drop-in-centers. The study involved interviews conducted using an adapted version of the WHO Drug Injection Study Phase II (Version 2b) questionnaire and blood testing for the HCV antibody, hepatitis B surface antigen, and hepatitis B core antibody. A logistic regression model was used to identify independent factors correlated with HCV and HBV infections. RESULTS:HCV infection was found to be primarily associated with female gender [odds ratio (OR) 5.0, 95% confidence interval (CI) 2.0-10.0)], unmarried status (OR 2.9, 95% CI 1.9-4.4), drug use for more than 10 years (OR 2.7, 95% CI 1.8-3.9), drug injection frequency of more than once per day (OR 2.6, 95% CI 1.6-4.2), history of imprisonment (OR 2.5, 95% CI 1.6-4.0)], and a history of shared injection needles in prison (OR 2.3, 95% CI 1.5-3.6). HBV infection was mainly correlated with a history of imprisonment (OR 1.9, 95% CI 1.4-2.7) and drug use for more than 10 years (OR 1.4, 95% CI 1.1-1.9). CONCLUSIONS:Because a considerable number of IDUs in Iran are receiving reduction services, tailoring services for prevention of hepatitis infection are necessary.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Amin-Esmaeili M,Rahimi-Movaghar A,Razaghi EM,Baghestani AR,Jafari Sdoi
10.5812/kowsar.1735143X.806subject
Has Abstractpub_date
2012-01-01 00:00:00pages
23-31issue
1eissn
1735-143Xissn
1735-3408journal_volume
12pub_type
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pub_type: 杂志文章,评审
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更新日期:2014-08-17 00:00:00
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abstract:BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was...
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abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...
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更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES:To determine the prevalence of HBV infections and risk factors for the disease for the first time in B...
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更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:There are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (NAFLD) in different populations. However, the existing literature lacks powerful studies addressing the factors which may predict the severity of NAFLD. OBJECTIVES:In the current study, we a...
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更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...
journal_title:Hepatitis monthly
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abstract::Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively. ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-02-01 00:00:00
abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...
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pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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更新日期:2013-08-13 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11138
更新日期:2013-08-12 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions. OBJECTIVES:To determine a strategy for discriminating patients with HBeAg-negative CHB fr...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
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更新日期:2016-02-29 00:00:00