Abstract:
BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was carried-out to investigate the association of IFNL3 gene polymorphisms (rs12979860 and rs8099917) with HBV susceptibility, in chronic HBV-infected patients. PATIENTS AND METHODS:In this case-control study, we determined IFNL3 single nucleotide polymorphisms (SNPs) (rs12979860 and rs8099917) in 221 individuals, with chronic HBV infection, and 200 healthy individuals, who were voluntary blood donors, with negative test for HBV. Alleles and genotypes analyses were performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. RESULTS:The frequencies of the rs12979860 and rs8099917 genotypes were not significantly different between the HBV-infected and the control groups (CC:CT:TT of 30.3%:48.0%:21.7% vs. 33.0%:49.0%:18.0%, P > 0.05, and GG:GT:TT of 5.8%:39.4%:54.8% vs. 5.0%:41.0%:54.0%, P > 0.05, respectively). Also, the frequencies of the alleles were not significantly different between both groups (C:T of 54.3%:45.7% vs. 57.5%:42.5%, P > 0.05, and G:T of 25.6%:74.4% vs. 25.5%:74.5%, P > 0.05, respectively) and the chronic HBV infection. There were no significant differences between patients, with at least one rs12979860C and or rs8099917T alleles compared to the healthy controls (rs12979860: CT + CC:TT, OR = 1.26, 95%CI = 0.78 - 2.04, P = 0.341 and rs8099917: GT + TT:GG, OR = 1.03, 95%CI = 0.70 - 1.51, P = 0.877, respectively). CONCLUSIONS:Our study showed no correlation between rs12979860 and rs8099917 SNPs and chronic HBV infection. Further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Heidari Z,Moudi B,Mahmoudzadeh-Sagheb H,Hashemi Mdoi
10.5812/hepatmon.34266subject
Has Abstractpub_date
2016-03-05 00:00:00pages
e34266issue
3eissn
1735-143Xissn
1735-3408journal_volume
16pub_type
杂志文章abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...
journal_title:Hepatitis monthly
pub_type:
doi:10.5812/hepatmon.41933
更新日期:2016-10-30 00:00:00
abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.9611
更新日期:2013-05-30 00:00:00
abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31490
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.39097
更新日期:2016-06-28 00:00:00
abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...
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更新日期:2015-03-05 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.14476
更新日期:2014-01-23 00:00:00
abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
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pub_type: 杂志文章
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更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143x.718
更新日期:2011-08-01 00:00:00
abstract::Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) an...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV) are transmitted by blood transfusion. Thus, hemodialysis (HD) patients are more prone to become the carriers of these infections due to their treatment demands. OBJECTIVES:The aim of this study was to assess the prevale...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.32971
更新日期:2016-01-23 00:00:00
abstract:BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15900
更新日期:2014-02-25 00:00:00
abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.789
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES:In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-year old adolescents was...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.723
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.32692
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.28751
更新日期:2016-02-29 00:00:00
abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.13162
更新日期:2013-08-25 00:00:00
abstract:BACKGROUND:Despite improvement in hepatitis B infection prevention through national vaccination programs, implementation of compulsory and thorough blood donor screening, and reduction of transfusion numbers due to erythropoietin administration,hepatitis B remains a major concern in hemodialysis (HD) centers [1]. Compa...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.751
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions. OBJECTIVES:To determine a strategy for discriminating patients with HBeAg-negative CHB fr...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Good knowledge, attitude and practice (KAP) of the physicians allow them to handle their patients in such a way that they prevent themselves from contracting, and their patients from spreading, the infection. However, the Iranian standardized KAP questionnaire of physicians about viral hepatitis is not avail...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7650
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.24635
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarker...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10810
更新日期:2013-06-16 00:00:00
abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.22649
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.18322
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In chronic liver diseases, a correct estimation of the severity of liver fibrosis is important for recommendations regarding the treatment. Nowadays, evaluation of fibrosis is done by noninvasive methods such as biochemical scores and transient elastography instead of liver biopsy. The lack of sensitivity to...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.38726
更新日期:2016-12-14 00:00:00
abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.34432
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES:To determine the prevalence of HBV infections and risk factors for the disease for the first time in B...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.36452
更新日期:2016-08-14 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...
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pub_type: 杂志文章
doi:10.5812/hepatmon.28287v2
更新日期:2015-07-22 00:00:00
abstract:CONTEXT:Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emerged especially for the broad spectrum of hepat...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.11215
更新日期:2013-08-14 00:00:00