Biliary Intraepithelial Neoplasia (BilIN) in Primary Sclerosing Cholangitis: The First Report from Iran.


BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to cholangiocarcinoma. There are very few studies about the frequency of BilIN in the patients with PSC and its correlation with paraclinical findings. OBJECTIVES:In this study, we tried to find the frequency of BilIN in the patients with PSC and correlate its presence with clinicopathologic factors. METHODS:During two years (2014 - 15) of investigation, 80 explanted livers with the confirmed diagnosis of PSC were studied through precise inspection and thorough sectioning of the explanted livers. These findings were correlated with paraclinical findings to identify any predictor of these neoplastic epithelial changes. RESULTS:During the study period of 2 years, among 80 livers with confirmed diagnosis of PSC, there were 43 cases with different types of metaplasia. The frequency of epithelial changes was as below: 29 (35%) for pyloric metaplasia, 9 (10.8%) for mucinous metaplasia, 3 (3.6%) for intestinal metaplasia, 1 (1.2%) for osteoid metaplasia, and 1 (1.2%) for squamous metaplasia. There was no epithelial dysplasia in the study sample; however, according to the most recent reports, mucinous metaplasia is considered as BilIN 1; therefore, there would be 9 cases of BilIN I. There has been no statistically significant difference between PSC cases and those with BilIN in demographic variables, except for bilirubin and CA19-9 which were higher in the PSC cases with BilIN. CONCLUSIONS:This study showed that the frequency of BilIN was low among Iranian patients with PSC. High bilirubin and CA19-9 can be predictors of the development of bile duct epithelial changes in patients with PSC.


Hepat Mon


Hepatitis monthly


Akbarzadeh L,Geramizadeh B,Kazemi K,Nikeghbalian S,Malekhosseini S




Has Abstract


2016-12-14 00:00:00












  • Hepatitis C in Pakistan: a review of available data.

    abstract::Hepatitis C virus (HCV) infection is increasingly recognized as a major health care problem, and is found frequently in Pakistani settings. In this article we reviewed published and unpublished data related to the seroepidemiology of HCV infection in Pakistan. For this article, data from 132 published studies and thre...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Umar M,Bushra HT,Ahmad M,Data A,Ahmad M,Khurram M,Usman S,Arif M,Adam T,Minhas Z,Arif A,Naeem A,Ejaz K,Butt Z,Bilal M

    更新日期:2010-07-01 00:00:00

  • Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis.

    abstract:BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Rezaee R,Poorebrahim M,Najafi S,Sadeghi S,Pourdast A,Alavian SM,Alavian SE,Poortahmasebi V

    更新日期:2016-06-28 00:00:00

  • The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice: The optimal dose of ribavirin for chronic hepatitis C.

    abstract::Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) an...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Abenavoli L,Mazza M,Almasio PL

    更新日期:2011-04-01 00:00:00

  • Trends in the Incidence Rates of Chronic Hepatitis B in Poland in the Years 2005 - 2013.

    abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Stawinska-Witoszynska B,Zysnarska M,Krzywinska-Wiewiorowska M,Wojtyła-Buciorab P,Krzyzaniak A,Wieckowska B

    更新日期:2016-07-25 00:00:00

  • Decrease of serum Angiotensin converting enzyme levels upon telbivudine treatment for chronic hepatitis B virus infection and negative correlations between the enzyme levels and estimated glumerular filtration rates.

    abstract:BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Liang KH,Chen YC,Hsu CW,Chang ML,Yeh CT

    更新日期:2014-01-31 00:00:00

  • Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.

    abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Lin H,Zhao H,Tang X,Hu W,Jiang N,Zhu S,Huang C

    更新日期:2016-10-02 00:00:00

  • Intrahepatic Toll-Like Receptor 3 in Chronic HBV Infection Subjects: Asymptomatic Carriers, Active Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma.

    abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Yin JW,Ping Huang M,Zhong B

    更新日期:2016-05-23 00:00:00

  • Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography: Fibroscan in inactive HBsAg carriers.

    abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Sporea I,Nicolita D,Sirli R,Deleanu A,Tudora A,Bota S

    更新日期:2011-03-01 00:00:00

  • Liver disease in cystic fibrosis: an update.

    abstract:CONTEXT:Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emerged especially for the broad spectrum of hepat...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审


    authors: Parisi GF,Di Dio G,Franzonello C,Gennaro A,Rotolo N,Lionetti E,Leonardi S

    更新日期:2013-08-14 00:00:00

  • The Clinical Significance of Serum Apoptotic Cytokeratin 18 Neoepitope M30 (CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels in Chronic Hepatitis B Patients with Cirrhosis.

    abstract:BACKGROUND:Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apopto...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Sumer S,Aktug Demir N,Kölgelier S,Cagkan Inkaya A,Arpaci A,Saltuk Demir L,Ural O

    更新日期:2013-06-26 00:00:00

  • HCV NS3 Blocking Effect on IFN Induced ISGs Like Viperin and IL28 With and Without NS4A.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Khanlari Z,Sabahi F,Hosseini SY,Ghaderi M

    更新日期:2014-06-08 00:00:00

  • Evaluation of the effects of oral N-acetylcysteine and a placebo in paraclinical and oxidative stress parameters of patients with chronic hepatitis B.

    abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Shohrati M,Dermanaki F,Babaei F,Alavian SM

    更新日期:2010-04-01 00:00:00

  • The Relationship between Intestinal Motility and Interstitial Cells of Cajal in Nonalcoholic Fatty Liver Mice.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestina...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Lu ML,Huang H,Liu LM,Chang J

    更新日期:2013-10-01 00:00:00

  • Sequencing and Phylogenetic Study of Partial NS3 Gene of Iranian GB Virus C/Hepatitis G Virus (HGV) Originated From Hemodialysis Patients in Tehran.

    abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Dadmanesh M,Ranjbar MM,Alavian SM,Ghorban K

    更新日期:2015-03-05 00:00:00

  • Epidemiology of hepatitis B in the reproductive-age female farmworkers of southeastern Turkey.

    abstract:BACKGROUND:There are limited data on the prevalence of the hepatitis B virus (HBV) infection in the agricultural population worldwide. OBJECTIVES:This study aimed to determine the prevalence of HBV infection and associated risk factors in the reproductive-age female farmworker. MATERIALS AND METHODS:This cross-sectio...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Yentur Doni N,Simsek Z,Keklik Z,Gurses G,Zeyrek FY

    更新日期:2014-11-23 00:00:00

  • Chronic hepatitis C in saudi arabia: three years local experience in a university hospital.

    abstract:BACKGROUND:Chronic hepatitis C (CHC) is a global infection. In Saudi Arabia, the prevalence of CHC is declining due to the implementation of a blood screening program. However, CHC still remains a leading cause of liver cirrhosis and hepatocellular carcinoma. OBJECTIVES:This is a retrospective study of CHC patients at...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Akbar HO,Al Ghamdi A,Qattan F,Fallatah HI,Al Rumani M

    更新日期:2012-09-01 00:00:00

  • Clinical Profile and HLA Typing of Autoimmune Hepatitis From Pakistan.

    abstract:BACKGROUND:Human leukocyte antigen (HLA) typing in autoimmune hepatitis (AIH) has been investigated in different populations and ethnic groups, but no such data is available from Pakistan. OBJECTIVES:The aim of this study was to evaluate the clinical profile of autoimmune hepatitis (AIH), and determine the associated ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Hassan N,Siddiqui AR,Abbas Z,Hassan SM,Soomro GB,Mubarak M,Anis S,Muzaffar R,Zafar MN

    更新日期:2013-12-16 00:00:00

  • Interferon alpha-2b therapy in chronic hepatitis delta.

    abstract:BACKGROUND:Approximately 5% of hepatitis B virus (HBV) carriers are coinfected with hepatitis D virus (HDV). HBV/HDV coinfection is a major cause of cirrhosis and end stage liver disease in chronic HBsAg carriers. The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or c...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Keshvari M,Alavian SM,Sharafi H,Karimi G,Gholami Fesharaki M

    更新日期:2014-03-01 00:00:00

  • Effect of hepatitis B virus genotypes on the efficacy of adefovir dipivoxil antiviral therapy.

    abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Wen Z,Zhang H,Zhang M,Tan D,Li Q,Zhang H,Wu P,Deng L

    更新日期:2014-08-17 00:00:00

  • Liver storage disease in Iran: a ten year study of liver biopsies in Children Medical Center Hospital in Tehran-Iran.

    abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Motamed F,Monajemzadeh M,Seifirad S,Ashrafi M,Rasti A,Mahjoub F

    更新日期:2011-08-01 00:00:00

  • Cost-effectiveness analysis of adding low dose ribavirin to peginterferon alfa-2a for treatment of chronic hepatitis C infected thalassemia major patients in iran.

    abstract:BACKGROUND:The prevalence of hepatitis C in Iran is 1% and 18% in general population and thalassemia patients respectively. The cost effectiveness analysis of adding Ribavirin to Peginterferon alfa-2a (PEG IFN alfa-2a) as a combination treatment strategy of chronic hepatitis C in thalassemia patients in comparison with...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Mehrazmay A,Alavian SM,Moradi-Lakeh M,Mokhtari Payam M,Hashemi-Meshkini A,Behnava B,Miri SM,Karimi Elizee P,Tabatabaee SV,Keshvari M,Bagheri Lankarani K

    更新日期:2013-09-01 00:00:00

  • Vaccination Against Hepatitis A for Hemophilic Patients: Is It Necessary?

    abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Mirzaei J,Ziaee M,Farsad SA,Fereydooni M,Anani Sarab G,Rezvani Khorashad MR

    更新日期:2016-04-05 00:00:00

  • G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.

    abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Suppiah J,Mohd Zain R,Bahari N,Haji Nawi S,Saat Z

    更新日期:2015-10-28 00:00:00

  • Trends in the Burden of Hepatitis B in a Southern Brazilian State.

    abstract:BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Marcon CE,Schneider IJ,Schuelter-Trevisol F,Traebert J

    更新日期:2015-11-28 00:00:00

  • Persistence of HBV Vaccine's Protection and Response to Hepatitis B Booster Immunization in 5- to 7-Year-Old Children in the Kohgiloyeh and Boyerahmad Province, Iran.

    abstract:BACKGROUND AND AIMS:The duration of the protection of hepatitis B vaccination for infants and the necessity of a booster dose administration is unknown. The aim of the present study was to evaluate the persistence of seroprotection after hepatitis B virus (HBV) vaccination in order to determine the necessity of a singl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Yazdanpanah B,Safari M,Yazdanpanah S

    更新日期:2010-01-01 00:00:00

  • Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology.

    abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Rostami Z,Lessan Pezeshki M,Soleimani Najaf Abadi A,Einollahi B

    更新日期:2013-05-30 00:00:00

  • Dilemma of HBsAg seroconversion in chronic hepatitis B infection: Dilemma of HBsAg in chronic HBV.

    abstract::Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively. ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Alavian SM,Miri SM

    更新日期:2011-02-01 00:00:00

  • Hepatitis Viruses B and D and Human Immunodeficiency Virus Infections in Hemodialysis Patients in the South of Iran: Prevalence and Genotypes.

    abstract:BACKGROUND:Hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV) are transmitted by blood transfusion. Thus, hemodialysis (HD) patients are more prone to become the carriers of these infections due to their treatment demands. OBJECTIVES:The aim of this study was to assess the prevale...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Bahri F,Kargar Kheirabad A,Ghasemzadeh I,Shoja S,Gouklani H

    更新日期:2016-01-23 00:00:00

  • Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes.

    abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Minosse C,Coen S,Visco Comandini U,Lionetti R,Montalbano M,Cerilli S,Vincenti D,Baiocchini A,Capobianchi MR,Menzo S

    更新日期:2016-02-29 00:00:00

  • In Vitro Analysis of CsA-Induced Hepatotoxicity in HepG2 Cell Line: Oxidative Stress and α2 and β1 Integrin Subunits Expression.

    abstract:BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章


    authors: Mostafavi-Pour Z,Khademi F,Zal F,Sardarian AR,Amini F

    更新日期:2013-08-13 00:00:00