The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice: The optimal dose of ribavirin for chronic hepatitis C.

Abstract:

:Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) and ribavirin (RBV). Several studies have suggested several potential new approaches to improve HCV therapy-optimization of the dose and duration of RBV therapy, accompanied by careful clinical management, is crucial in ensuring the greatest likelihood of a long response to therapy. RBV causes serious side effects, but in clinical practice, there are no alternatives for the treatment of HCV infection. Based on our results, weight-based doses of RBV are advantageous for genotype 1-infected patients, but its success in genotype 2- and 3-infected patients is unknown, particularly for shorter treatment durations.

journal_name

Hepat Mon

journal_title

Hepatitis monthly

authors

Abenavoli L,Mazza M,Almasio PL

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

240-6

issue

4

eissn

1735-143X

issn

1735-3408

journal_volume

11

pub_type

杂志文章
  • Vaccination Against Hepatitis A for Hemophilic Patients: Is It Necessary?

    abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.37447

    authors: Mirzaei J,Ziaee M,Farsad SA,Fereydooni M,Anani Sarab G,Rezvani Khorashad MR

    更新日期:2016-04-05 00:00:00

  • Epidemiological impact of mandatory vaccination against hepatitis B in Italian young adults.

    abstract:BACKGROUND:Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES:In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-year old adolescents was...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.723

    authors: Campagna M,Siddu A,Meloni A,Murru C,Masia G,Coppola RC

    更新日期:2011-09-01 00:00:00

  • Interferon alpha-2b therapy in chronic hepatitis delta.

    abstract:BACKGROUND:Approximately 5% of hepatitis B virus (HBV) carriers are coinfected with hepatitis D virus (HDV). HBV/HDV coinfection is a major cause of cirrhosis and end stage liver disease in chronic HBsAg carriers. The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or c...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15729

    authors: Keshvari M,Alavian SM,Sharafi H,Karimi G,Gholami Fesharaki M

    更新日期:2014-03-01 00:00:00

  • Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology.

    abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.9611

    authors: Rostami Z,Lessan Pezeshki M,Soleimani Najaf Abadi A,Einollahi B

    更新日期:2013-05-30 00:00:00

  • Recent advances in radiofrequency ablation for the management of hepatocellular carcinoma.

    abstract:UNLABELLED:CONTEXTS: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases in the world. Because less than 20% of patients with HCC are resectable, various types of non-surgical treatment have been developed. EVIDENCE ACQUISITION:At present, radiofrequency ablation (RFA) is accepted as the standa...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.5945

    authors: Himoto T,Kurokohchi K,Watanabe S,Masaki T

    更新日期:2012-10-01 00:00:00

  • Dilemma of HBsAg seroconversion in chronic hepatitis B infection: Dilemma of HBsAg in chronic HBV.

    abstract::Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively. ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Alavian SM,Miri SM

    更新日期:2011-02-01 00:00:00

  • Prognostic values of fluctuations in serum levels of alanine transaminase in inactive carrier state of HBV infection.

    abstract:BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.17537

    authors: Farzi H,Ebrahimi Daryani N,Mehrnoush L,Salimi S,Alavian SM

    更新日期:2014-05-01 00:00:00

  • HCV NS3 Blocking Effect on IFN Induced ISGs Like Viperin and IL28 With and Without NS4A.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.17822

    authors: Khanlari Z,Sabahi F,Hosseini SY,Ghaderi M

    更新日期:2014-06-08 00:00:00

  • Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review.

    abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.8340

    authors: Modabbernia A,Poustchi H,Malekzadeh R

    更新日期:2013-01-01 00:00:00

  • Effect of hepatitis B virus genotypes on the efficacy of adefovir dipivoxil antiviral therapy.

    abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.10813

    authors: Wen Z,Zhang H,Zhang M,Tan D,Li Q,Zhang H,Wu P,Deng L

    更新日期:2014-08-17 00:00:00

  • The role of interleukin-6 and interleukin-8 gene polymorphisms in non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.24635

    authors: Cengiz M,Yasar DG,Ergun MA,Akyol G,Ozenirler S

    更新日期:2014-12-24 00:00:00

  • The Clinical Significance of Serum Apoptotic Cytokeratin 18 Neoepitope M30 (CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels in Chronic Hepatitis B Patients with Cirrhosis.

    abstract:BACKGROUND:Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apopto...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.10106

    authors: Sumer S,Aktug Demir N,Kölgelier S,Cagkan Inkaya A,Arpaci A,Saltuk Demir L,Ural O

    更新日期:2013-06-26 00:00:00

  • The role of anesthetic drugs in liver apoptosis.

    abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审

    doi:10.5812/hepatmon.13162

    authors: Dabbagh A,Rajaei S

    更新日期:2013-08-25 00:00:00

  • Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection.

    abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.28287v2

    authors: Ghaleh Baghi S,Alavian SM,Mehrnoush L,Salimi S

    更新日期:2015-07-22 00:00:00

  • Liver storage disease in Iran: a ten year study of liver biopsies in Children Medical Center Hospital in Tehran-Iran.

    abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143x.718

    authors: Motamed F,Monajemzadeh M,Seifirad S,Ashrafi M,Rasti A,Mahjoub F

    更新日期:2011-08-01 00:00:00

  • Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.

    abstract:BACKGROUND:There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production. OBJECTIVES:To investigate the potential association of two polymorphisms ( 137G/C a...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Wu L,Chen L,Zhou L,Xie H,Wei B,Yin S,Ye Y,Fang W,Zheng S

    更新日期:2011-06-01 00:00:00

  • The Risk of Hepatocellular Carcinoma After Directly Acting Antivirals for Hepatitis C Virus Treatment in Liver Transplanted Patients: Is It Real?

    abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...

    journal_title:Hepatitis monthly

    pub_type:

    doi:10.5812/hepatmon.41933

    authors: Strazzulla A,Iemmolo RMR,Carbone E,Postorino MC,Mazzitelli M,De Santis M,Di Benedetto F,Cristiani CM,Costa C,Pisani V,Torti C

    更新日期:2016-10-30 00:00:00

  • Hematological Adverse events and Sustained Viral Response in Children Undergoing Therapy for Chronic Hepatitis C Infection.

    abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.789

    authors: Pawlowska M,Pilarczyk M,Foksinska A,Smukalska E,Halota W

    更新日期:2011-12-01 00:00:00

  • A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan.

    abstract:BACKGROUND:Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. OBJECTIVES:To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world. PATIENTS AND METHODS:We conducted a prosp...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Mumtaz K,Hamid S,Ahmed S,Moatter T,Mushtaq S,Khan A,Mizokami M,Jafri W

    更新日期:2011-01-01 00:00:00

  • Sequencing and Phylogenetic Study of Partial NS3 Gene of Iranian GB Virus C/Hepatitis G Virus (HGV) Originated From Hemodialysis Patients in Tehran.

    abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.24173

    authors: Dadmanesh M,Ranjbar MM,Alavian SM,Ghorban K

    更新日期:2015-03-05 00:00:00

  • Duct-to-Duct Biliary Anastomosis Yields Similar Outcomes to Roux-en-Y Hepaticojejunostomy in Liver Transplantation for Primary Sclerosing Cholangitis.

    abstract:BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15(5)2015.18811

    authors: Al-Judaibi B,Hernandez Alejandro R,Uhanova J,Marotta P,Mosli M,Chandok N

    更新日期:2015-05-23 00:00:00

  • Evaluation of prevalence and risk factors of hepatitis g virus infection among hemodialysis patients referred to Iranian army hospitals in tehran during 2012-2013.

    abstract:BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.18322

    authors: Dadmanesh M,Hosseinzadeh M,Keyvani H,Ghorban K,Rahimi M,Hosseinzadeh M,Ranjbar MM

    更新日期:2015-01-01 00:00:00

  • Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.

    abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.40492

    authors: Lin H,Zhao H,Tang X,Hu W,Jiang N,Zhu S,Huang C

    更新日期:2016-10-02 00:00:00

  • The Relationship between Intestinal Motility and Interstitial Cells of Cajal in Nonalcoholic Fatty Liver Mice.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestina...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.13674

    authors: Lu ML,Huang H,Liu LM,Chang J

    更新日期:2013-10-01 00:00:00

  • Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran.

    abstract:BACKGROUND:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. OBJECTIVES:The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.806

    authors: Amin-Esmaeili M,Rahimi-Movaghar A,Razaghi EM,Baghestani AR,Jafari S

    更新日期:2012-01-01 00:00:00

  • Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography: Fibroscan in inactive HBsAg carriers.

    abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Sporea I,Nicolita D,Sirli R,Deleanu A,Tudora A,Bota S

    更新日期:2011-03-01 00:00:00

  • Trends in the Incidence Rates of Chronic Hepatitis B in Poland in the Years 2005 - 2013.

    abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.32692

    authors: Stawinska-Witoszynska B,Zysnarska M,Krzywinska-Wiewiorowska M,Wojtyła-Buciorab P,Krzyzaniak A,Wieckowska B

    更新日期:2016-07-25 00:00:00

  • G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.

    abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.31490

    authors: Suppiah J,Mohd Zain R,Bahari N,Haji Nawi S,Saat Z

    更新日期:2015-10-28 00:00:00

  • HAV Immunity in Iranian Medical Students.

    abstract:BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.26219

    authors: Hosseini Shokouh SJ,Dadashi A,Abiri M,Zohrevand I,Eshraghian A,Khoshdel A,Heidari B,Khoshkish S

    更新日期:2015-03-31 00:00:00

  • The Role of Interferon Gamma Gene Polymorphism (+874A/T, +2109A/G, and -183G/T) in Response to Treatment Among Hepatitis C Infected Patients in Fars Province, Southern Iran.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.14476

    authors: Sarvari J,Norozian H,Fattahi MR,Pirbonyeh N,Moattari A

    更新日期:2014-01-23 00:00:00