Abstract:
:Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) and ribavirin (RBV). Several studies have suggested several potential new approaches to improve HCV therapy-optimization of the dose and duration of RBV therapy, accompanied by careful clinical management, is crucial in ensuring the greatest likelihood of a long response to therapy. RBV causes serious side effects, but in clinical practice, there are no alternatives for the treatment of HCV infection. Based on our results, weight-based doses of RBV are advantageous for genotype 1-infected patients, but its success in genotype 2- and 3-infected patients is unknown, particularly for shorter treatment durations.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Abenavoli L,Mazza M,Almasio PLsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
240-6issue
4eissn
1735-143Xissn
1735-3408journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.37447
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES:In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-year old adolescents was...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.723
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Approximately 5% of hepatitis B virus (HBV) carriers are coinfected with hepatitis D virus (HDV). HBV/HDV coinfection is a major cause of cirrhosis and end stage liver disease in chronic HBsAg carriers. The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or c...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15729
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.9611
更新日期:2013-05-30 00:00:00
abstract:UNLABELLED:CONTEXTS: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases in the world. Because less than 20% of patients with HCC are resectable, various types of non-surgical treatment have been developed. EVIDENCE ACQUISITION:At present, radiofrequency ablation (RFA) is accepted as the standa...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.5945
更新日期:2012-10-01 00:00:00
abstract::Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively. ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.17537
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.17822
更新日期:2014-06-08 00:00:00
abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.8340
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10813
更新日期:2014-08-17 00:00:00
abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.24635
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apopto...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10106
更新日期:2013-06-26 00:00:00
abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.13162
更新日期:2013-08-25 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.28287v2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143x.718
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production. OBJECTIVES:To investigate the potential association of two polymorphisms ( 137G/C a...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...
journal_title:Hepatitis monthly
pub_type:
doi:10.5812/hepatmon.41933
更新日期:2016-10-30 00:00:00
abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.789
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. OBJECTIVES:To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world. PATIENTS AND METHODS:We conducted a prosp...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.24173
更新日期:2015-03-05 00:00:00
abstract:BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15(5)2015.18811
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.18322
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.40492
更新日期:2016-10-02 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestina...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.13674
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. OBJECTIVES:The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143X.806
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.32692
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31490
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.26219
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.14476
更新日期:2014-01-23 00:00:00