A Single Center Study Comparing the Stainable Iron Depositions in 1000 Explanted Cirrhotic Livers of Different Causes.

Abstract:

BACKGROUND:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. OBJECTIVES:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. PATIENTS AND METHODS:In this 7 year study (2008 - 2014), in 1000 explanted livers, the amount of iron was scored and compared according to the cause of the cirrhosis. The amount of iron in the liver was determined via the histochemical staining of the liver tissue, using Prussian-blue staining. Additionally, in each patient, the serum iron was determined and compared according to the cause of cirrhosis. RESULTS:The highest content of iron has been found in cirrhosis caused by chronic hepatitis (i.e. hepatitis B, C, and autoimmune hepatitis), as well as in alcoholic cirrhosis. The least amount of stainable iron has been shown in biliary cirrhosis. CONCLUSIONS:The presence of high stainable iron in patients with cirrhosis, secondary to chronic viral hepatitis, autoimmune hepatitis, and alcoholic hepatitis, should not be considered indicative of the presence of hereditary hemochromatosis; however, in those patients with biliary cirrhosis, a high iron content is rare, and can be a sign of the presence of the high iron Fe (HFE) gene mutation, or another type of hereditary hemochromatosis.

journal_name

Hepat Mon

journal_title

Hepatitis monthly

authors

Geramizadeh B,Ghazanfari Y,Nikeghbalian S,Malekhosseini SA

doi

10.5812/hepatmon.33710

subject

Has Abstract

pub_date

2015-12-28 00:00:00

pages

e33710

issue

12

eissn

1735-143X

issn

1735-3408

journal_volume

15

pub_type

杂志文章
  • Decrease of serum Angiotensin converting enzyme levels upon telbivudine treatment for chronic hepatitis B virus infection and negative correlations between the enzyme levels and estimated glumerular filtration rates.

    abstract:BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15074

    authors: Liang KH,Chen YC,Hsu CW,Chang ML,Yeh CT

    更新日期:2014-01-31 00:00:00

  • HAV Immunity in Iranian Medical Students.

    abstract:BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.26219

    authors: Hosseini Shokouh SJ,Dadashi A,Abiri M,Zohrevand I,Eshraghian A,Khoshdel A,Heidari B,Khoshkish S

    更新日期:2015-03-31 00:00:00

  • Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes.

    abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.28751

    authors: Minosse C,Coen S,Visco Comandini U,Lionetti R,Montalbano M,Cerilli S,Vincenti D,Baiocchini A,Capobianchi MR,Menzo S

    更新日期:2016-02-29 00:00:00

  • Epidemiological impact of mandatory vaccination against hepatitis B in Italian young adults.

    abstract:BACKGROUND:Viral hepatitis caused by hepatitis B virus (HBV) is a leading cause of acute and chronic liver diseases worldwide. OBJECTIVES:In Italy, a mandatory vaccination policy was introduced in 1991 and was established for all newborns and 12-year-old individuals. In 2004, vaccination of 12-year old adolescents was...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.723

    authors: Campagna M,Siddu A,Meloni A,Murru C,Masia G,Coppola RC

    更新日期:2011-09-01 00:00:00

  • Biliary Intraepithelial Neoplasia (BilIN) in Primary Sclerosing Cholangitis: The First Report from Iran.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.38726

    authors: Akbarzadeh L,Geramizadeh B,Kazemi K,Nikeghbalian S,Malekhosseini S

    更新日期:2016-12-14 00:00:00

  • The Relationship between Intestinal Motility and Interstitial Cells of Cajal in Nonalcoholic Fatty Liver Mice.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestina...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.13674

    authors: Lu ML,Huang H,Liu LM,Chang J

    更新日期:2013-10-01 00:00:00

  • The Risk of Hepatocellular Carcinoma After Directly Acting Antivirals for Hepatitis C Virus Treatment in Liver Transplanted Patients: Is It Real?

    abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...

    journal_title:Hepatitis monthly

    pub_type:

    doi:10.5812/hepatmon.41933

    authors: Strazzulla A,Iemmolo RMR,Carbone E,Postorino MC,Mazzitelli M,De Santis M,Di Benedetto F,Cristiani CM,Costa C,Pisani V,Torti C

    更新日期:2016-10-30 00:00:00

  • The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice: The optimal dose of ribavirin for chronic hepatitis C.

    abstract::Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) an...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Abenavoli L,Mazza M,Almasio PL

    更新日期:2011-04-01 00:00:00

  • Trends in the Burden of Hepatitis B in a Southern Brazilian State.

    abstract:BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.31906

    authors: Marcon CE,Schneider IJ,Schuelter-Trevisol F,Traebert J

    更新日期:2015-11-28 00:00:00

  • The Correlation Between Interferon Lambda 3 Gene Polymorphisms and Susceptibility to Hepatitis B Virus Infection.

    abstract:BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.34266

    authors: Heidari Z,Moudi B,Mahmoudzadeh-Sagheb H,Hashemi M

    更新日期:2016-03-05 00:00:00

  • Hematological Adverse events and Sustained Viral Response in Children Undergoing Therapy for Chronic Hepatitis C Infection.

    abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.789

    authors: Pawlowska M,Pilarczyk M,Foksinska A,Smukalska E,Halota W

    更新日期:2011-12-01 00:00:00

  • The Role of Interferon Gamma Gene Polymorphism (+874A/T, +2109A/G, and -183G/T) in Response to Treatment Among Hepatitis C Infected Patients in Fars Province, Southern Iran.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.14476

    authors: Sarvari J,Norozian H,Fattahi MR,Pirbonyeh N,Moattari A

    更新日期:2014-01-23 00:00:00

  • Intrahepatic Toll-Like Receptor 3 in Chronic HBV Infection Subjects: Asymptomatic Carriers, Active Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma.

    abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.34432

    authors: Yin JW,Ping Huang M,Zhong B

    更新日期:2016-05-23 00:00:00

  • The role of anesthetic drugs in liver apoptosis.

    abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审

    doi:10.5812/hepatmon.13162

    authors: Dabbagh A,Rajaei S

    更新日期:2013-08-25 00:00:00

  • Dilemma of HBsAg seroconversion in chronic hepatitis B infection: Dilemma of HBsAg in chronic HBV.

    abstract::Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively. ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Alavian SM,Miri SM

    更新日期:2011-02-01 00:00:00

  • Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review.

    abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.8340

    authors: Modabbernia A,Poustchi H,Malekzadeh R

    更新日期:2013-01-01 00:00:00

  • Hepatitis C in Pakistan: a review of available data.

    abstract::Hepatitis C virus (HCV) infection is increasingly recognized as a major health care problem, and is found frequently in Pakistani settings. In this article we reviewed published and unpublished data related to the seroepidemiology of HCV infection in Pakistan. For this article, data from 132 published studies and thre...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Umar M,Bushra HT,Ahmad M,Data A,Ahmad M,Khurram M,Usman S,Arif M,Adam T,Minhas Z,Arif A,Naeem A,Ejaz K,Butt Z,Bilal M

    更新日期:2010-07-01 00:00:00

  • Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.

    abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.40492

    authors: Lin H,Zhao H,Tang X,Hu W,Jiang N,Zhu S,Huang C

    更新日期:2016-10-02 00:00:00

  • Analysis of T Cell Receptor Vβ Diversity in Peripheral CD4+ and CD8+ T Lymphocytes Obtained From Patients With Chronic Severe Hepatitis B.

    abstract:BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15900

    authors: Xiong Y,Tan Y,Song YG

    更新日期:2014-02-25 00:00:00

  • HCV NS3 Blocking Effect on IFN Induced ISGs Like Viperin and IL28 With and Without NS4A.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.17822

    authors: Khanlari Z,Sabahi F,Hosseini SY,Ghaderi M

    更新日期:2014-06-08 00:00:00

  • The Distribution of Hepatitis C Virus Genotypes in Middle Eastern Countries: A Systematic Review and Meta-Analysis.

    abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审

    doi:10.5812/hepatmon.40357

    authors: Ghaderi-Zefrehi H,Gholami-Fesharaki M,Sharafi H,Sadeghi F,Alavian SM

    更新日期:2016-08-23 00:00:00

  • Efficacy of HBV vaccination in various stages of chronic kidney disease: is earlier better?

    abstract:BACKGROUND:Despite improvement in hepatitis B infection prevention through national vaccination programs, implementation of compulsory and thorough blood donor screening, and reduction of transfusion numbers due to erythropoietin administration,hepatitis B remains a major concern in hemodialysis (HD) centers [1]. Compa...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.751

    authors: Hashemi B,Mahdavi-Mazdeh M,Abbasi M,Hosseini-Moghaddam SM,Zinat NH,Ahmadi F

    更新日期:2011-10-01 00:00:00

  • The Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study.

    abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.22649

    authors: Sharafi H,Alavian SM,Behnava B,Pouryasin A,Keshvari M

    更新日期:2014-10-01 00:00:00

  • Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population.

    abstract:BACKGROUND:There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production. OBJECTIVES:To investigate the potential association of two polymorphisms ( 137G/C a...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Wu L,Chen L,Zhou L,Xie H,Wei B,Yin S,Ye Y,Fang W,Zheng S

    更新日期:2011-06-01 00:00:00

  • How efficient is acoustic radiation force impulse elastography for the evaluation of liver stiffness?

    abstract:BACKGROUND:In chronic liver diseases, a correct estimation of the severity of liver fibrosis is important for recommendations regarding the treatment. Nowadays, evaluation of fibrosis is done by noninvasive methods such as biochemical scores and transient elastography instead of liver biopsy. The lack of sensitivity to...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Sporea I,Badea R,Sirli R,Lupsor M,Popescu A,Danila M,Focsa M,Deleanu A

    更新日期:2011-07-01 00:00:00

  • Low Serum Hepatitis B Surface Antigen Level Predicts Compensated Cirrhosis Caused by Chronic Hepatitis B in HBeAg Positive Patients in East China.

    abstract:BACKGROUNDS:Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection. OBJECTIVES:The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients. PATIENTS AN...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.29183

    authors: Jia W,Qi X,Ji YY,Xun YH,Wang H,Zhang WH,Yang JH,Wang JY,Zhu HX,Mao RC,Zhang JM

    更新日期:2015-08-30 00:00:00

  • LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes.

    abstract:BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15(5)2015.28473

    authors: Liu Y,Zou Z,Zhu B,Hu Z,Zeng P,Wu L

    更新日期:2015-05-23 00:00:00

  • Hepatitis B vaccination in chronic kidney disease: review of evidence in non-dialyzed patients.

    abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.7359

    authors: Grzegorzewska AE

    更新日期:2012-11-01 00:00:00

  • Duct-to-Duct Biliary Anastomosis Yields Similar Outcomes to Roux-en-Y Hepaticojejunostomy in Liver Transplantation for Primary Sclerosing Cholangitis.

    abstract:BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15(5)2015.18811

    authors: Al-Judaibi B,Hernandez Alejandro R,Uhanova J,Marotta P,Mosli M,Chandok N

    更新日期:2015-05-23 00:00:00

  • Liver disease in cystic fibrosis: an update.

    abstract:CONTEXT:Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emerged especially for the broad spectrum of hepat...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审

    doi:10.5812/hepatmon.11215

    authors: Parisi GF,Di Dio G,Franzonello C,Gennaro A,Rotolo N,Lionetti E,Leonardi S

    更新日期:2013-08-14 00:00:00