Abstract:
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestinal motor disorders, but little is known about the interstitial cells of Cajal (ICC) role in gastrointestinal motor disorders. OBJECTIVES:The aim of this study was to observe the ICC in jejunum of nonalcoholic fatty liver mice by immunohistochemistry and assessed the relationship between intestinal motility and ICC. MATERIALS AND METHODS:Thirty five Sprague-Dawley (SD) rats were randomly divided into nonalcoholic fatty liver (n = 25) and control groups (n = 10), rats were housed individually in cages and had free access to food and water, nonalcoholic fatty liver group was duplicated by high-fat diet (consisted of ordinary food, 20 g/kg cholesterol and 100 g/kg fat) feeding. Dextran blue-2000 was used to monitor the intestinal motility. The proximal small intestine was harvested to investigate the C-kit positive ICC. The hepatic tissue slices were used for pathological observation. RESULTS:Nonalcoholic fatty liver disease was successfully established. The intestinal motility in nonalcoholic fatty liver group (49.5 ± 10.9) was weaker compared to the control group (57.3 ± 8.9), P < 0.05. The rate of ICC also have shown statistically significant differences between nonalcoholic fatty liver (4.87 ± 2.97/mm (2)) and control groups (6.54 ± 3.13/mm (2)), P < 0.05. CONCLUSIONS:ICC may be related to the intestinal motility in nonalcoholic fatty liver mice.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Lu ML,Huang H,Liu LM,Chang Jdoi
10.5812/hepatmon.13674subject
Has Abstractpub_date
2013-10-01 00:00:00pages
e13674issue
10eissn
1735-143Xissn
1735-3408journal_volume
13pub_type
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