Abstract:
BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of success of DD reconstruction versus RYH, in PSC. OBJECTIVES:The aim of this study was to assess the safety and efficacy of DD anastomosis, compared to RYH reconstruction, among adults transplanted for PSC. PATIENTS AND METHODS:All adult patients, who underwent primary LT for PSC between 1990 and 2012, were evaluated, according to type of biliary reconstruction. Recipient and graft survival, postoperative medical and surgical complications, and postoperative resource utilization rates were compared between the two groups. RESULTS:Totally, 73 patients fulfilled the inclusion criteria. Of them, 58 had RYH and 15 had DD reconstruction. A total of 53 subjects (73%) were male, with the mean age ± standard deviation at LT of 43.3 ± 14.4 years. Rates of recipient mortality, graft failure, biliary complications, acute cellular rejection, and reoperation were similar in both groups. Postoperative cholangiography was used more frequently in patients with DD reconstruction (33.3% vs. 8.6%, P = 0.026). CONCLUSIONS:In selected recipients with PSC, DD reconstruction is a safe and efficacious technique, with long-term clinical outcomes comparable to RYH.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Al-Judaibi B,Hernandez Alejandro R,Uhanova J,Marotta P,Mosli M,Chandok Ndoi
10.5812/hepatmon.15(5)2015.18811subject
Has Abstractpub_date
2015-05-23 00:00:00pages
e18811issue
5eissn
1735-143Xissn
1735-3408journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
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