Abstract:
UNLABELLED:CONTEXTS: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases in the world. Because less than 20% of patients with HCC are resectable, various types of non-surgical treatment have been developed. EVIDENCE ACQUISITION:At present, radiofrequency ablation (RFA) is accepted as the standard local treatment for patients with HCC because of its superior local control and overall survival compared to other local treatments. RESULTS:New devices for RFA and combination treatments of RFA with other procedures have been developed to improve anti-tumoral effects. CONCLUSIONS:This review mainly focuses on the status of RFA in the management of HCC and recent advances in RFA treatment technology.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Himoto T,Kurokohchi K,Watanabe S,Masaki Tdoi
10.5812/hepatmon.5945subject
Has Abstractpub_date
2012-10-01 00:00:00pages
e5945issue
10 HCCeissn
1735-143Xissn
1735-3408journal_volume
12pub_type
杂志文章abstract:BACKGROUND:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. OBJECTIVES:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. PATIENTS AN...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.33710
更新日期:2015-12-28 00:00:00
abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.24635
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.14476
更新日期:2014-01-23 00:00:00
abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.8340
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Malnutrition is the most common cause of immune deficiency. It results in reduced secretion of T-cells and B-cell-stimulating factors leading to declining of special immunoglobulins. On the other hand, hepatitis B, as a major world health problem, can be prevented effectively by vaccination. Three doses of h...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7048
更新日期:2013-02-03 00:00:00
abstract:BACKGROUND:In spite of dozens of clinical trials to establish effective therapeutic and/or preventive vaccine to resolve HCV infection, no real vaccine has been proved to date. Genetic vaccines based on replication-defective adenoviruses have proved to elicit strong and long lasting T-cell responses against a number of...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.6130
更新日期:2012-08-01 00:00:00
abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.13162
更新日期:2013-08-25 00:00:00
abstract:BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.17537
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.28287v2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/kowsar.1735143x.718
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:There is growing evidence suggesting that interleukin-18 (IL-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (SNPs) within the gene may influence its production. OBJECTIVES:To investigate the potential association of two polymorphisms ( 137G/C a...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) typing in autoimmune hepatitis (AIH) has been investigated in different populations and ethnic groups, but no such data is available from Pakistan. OBJECTIVES:The aim of this study was to evaluate the clinical profile of autoimmune hepatitis (AIH), and determine the associated ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.13598
更新日期:2013-12-16 00:00:00
abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.34432
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:There are limited data on the prevalence of the hepatitis B virus (HBV) infection in the agricultural population worldwide. OBJECTIVES:This study aimed to determine the prevalence of HBV infection and associated risk factors in the reproductive-age female farmworker. MATERIALS AND METHODS:This cross-sectio...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.22120
更新日期:2014-11-23 00:00:00
abstract::Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) an...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15426
更新日期:2014-08-05 00:00:00
abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31490
更新日期:2015-10-28 00:00:00
abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.40357
更新日期:2016-08-23 00:00:00
abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10813
更新日期:2014-08-17 00:00:00
abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.37447
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31906
更新日期:2015-11-28 00:00:00
abstract:BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15(5)2015.28473
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.26219
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15074
更新日期:2014-01-31 00:00:00
abstract:BACKGROUND:Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES:To determine the prevalence of HBV infections and risk factors for the disease for the first time in B...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.36452
更新日期:2016-08-14 00:00:00
abstract:BACKGROUND:In chronic liver diseases, a correct estimation of the severity of liver fibrosis is important for recommendations regarding the treatment. Nowadays, evaluation of fibrosis is done by noninvasive methods such as biochemical scores and transient elastography instead of liver biopsy. The lack of sensitivity to...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarker...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.10810
更新日期:2013-06-16 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11447
更新日期:2013-08-13 00:00:00