Egy-score predicts severe hepatic fibrosis and cirrhosis in Egyptians with chronic liver diseases: a pilot study.

Abstract:

BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarkers for prediction of the stage of hepatic fibrosis by combining tumor markers with other known biomarkers of hepatic fibrosis. PATIENTS AND METHODS:A total of 92 patients with different types of chronic liver diseases (chronic hepatitis B, chronic hepatitis C and autoimmune hepatitis), were prospectively enrolled in our cohort. They were subjected to: ALT, AST, GGT, ALP, total bilirubin, INR, total cholesterol, albumin, platelet count, cancer antigen 19-9 (CA 19-9), cancer antigen 125 (CA 125), cancer antigen 15-3 (CA 15-3), haptoglobin, alpha-2-macroglobulin, apolipoprotein A1, abdominal ultrasound, liver biopsy and histological staging of hepatic fibrosis using the METAVIR system. RESULTS:Combined elevation of CA 19-9 and CA 125 with a summated value > 37 U/mL is predictive of severe hepatic fibrosis or cirrhosis (stage F3-F4 METAVIR) with a probability of 77.6%. Multivariate analysis showed that the most relevant collection of biomarkers for prediction of stage of hepatic fibrosis is: CA 19-9, age, alpha-2- macroglobulin, total bilirubin, platelet count & albumin. We developed a new score, named the "Egy-Score", using a regression equation composed of this panel of biomarkers. Egy-Score could differentiate no or early fibrosis (stage F0-F2 METAVIR) from severe fibrosis or cirrhosis (stage F3-F4 METAVIR) with 83.7% accuracy. CONCLUSIONS:Non-invasive assessment of hepatic fibrosis could be done using the Egy-Score. Egy-Score could differentiate no or early fibrosis (stage F0-F2 METAVIR) from severe fibrosis or cirrhosis (stage F3 - F4 METAVIR) with 83.7% accuracy.

journal_name

Hepat Mon

journal_title

Hepatitis monthly

authors

Alboraie MA,Afifi ME,Elghamry FG,Shalaby HA,Elshennawy GE,Abdelaziz AA,Shaheen MU,Abo El-Seoud AR

doi

10.5812/hepatmon.10810

subject

Has Abstract

pub_date

2013-06-16 00:00:00

pages

e10810

issue

6

eissn

1735-143X

issn

1735-3408

journal_volume

13

pub_type

杂志文章
  • Efficacy of HBV vaccination in various stages of chronic kidney disease: is earlier better?

    abstract:BACKGROUND:Despite improvement in hepatitis B infection prevention through national vaccination programs, implementation of compulsory and thorough blood donor screening, and reduction of transfusion numbers due to erythropoietin administration,hepatitis B remains a major concern in hemodialysis (HD) centers [1]. Compa...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143X.751

    authors: Hashemi B,Mahdavi-Mazdeh M,Abbasi M,Hosseini-Moghaddam SM,Zinat NH,Ahmadi F

    更新日期:2011-10-01 00:00:00

  • Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes.

    abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.28751

    authors: Minosse C,Coen S,Visco Comandini U,Lionetti R,Montalbano M,Cerilli S,Vincenti D,Baiocchini A,Capobianchi MR,Menzo S

    更新日期:2016-02-29 00:00:00

  • Effect of hepatitis B virus genotypes on the efficacy of adefovir dipivoxil antiviral therapy.

    abstract:BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.10813

    authors: Wen Z,Zhang H,Zhang M,Tan D,Li Q,Zhang H,Wu P,Deng L

    更新日期:2014-08-17 00:00:00

  • Hepatitis B vaccination in chronic kidney disease: review of evidence in non-dialyzed patients.

    abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.7359

    authors: Grzegorzewska AE

    更新日期:2012-11-01 00:00:00

  • Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review.

    abstract:CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.8340

    authors: Modabbernia A,Poustchi H,Malekzadeh R

    更新日期:2013-01-01 00:00:00

  • Trends in the Incidence Rates of Chronic Hepatitis B in Poland in the Years 2005 - 2013.

    abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.32692

    authors: Stawinska-Witoszynska B,Zysnarska M,Krzywinska-Wiewiorowska M,Wojtyła-Buciorab P,Krzyzaniak A,Wieckowska B

    更新日期:2016-07-25 00:00:00

  • Efficacy and Tolerability of Peginterferon alpha-2a and Peginterferon alpha-2b in Iranian Patients With Chronic Hepatitis C.

    abstract:BACKGROUND:Nearly 0.5% of Iranians are infected with HCV. Peginterferon-alpha-2a and Peginterferon-alpha-2b are the two available types of interferon for the treatment of hepatitis C. Comparing the results of these two treatments is still a challenge. OBJECTIVES:The aim of this study was to compare the results of Pegi...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.30780

    authors: Pouresmaeeli M,Alavian SM,Keshvari M,Salimi S,Mehrnoush L

    更新日期:2015-09-29 00:00:00

  • In Vitro Analysis of CsA-Induced Hepatotoxicity in HepG2 Cell Line: Oxidative Stress and α2 and β1 Integrin Subunits Expression.

    abstract:BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.11447

    authors: Mostafavi-Pour Z,Khademi F,Zal F,Sardarian AR,Amini F

    更新日期:2013-08-13 00:00:00

  • Biliary Intraepithelial Neoplasia (BilIN) in Primary Sclerosing Cholangitis: The First Report from Iran.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.38726

    authors: Akbarzadeh L,Geramizadeh B,Kazemi K,Nikeghbalian S,Malekhosseini S

    更新日期:2016-12-14 00:00:00

  • Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography: Fibroscan in inactive HBsAg carriers.

    abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Sporea I,Nicolita D,Sirli R,Deleanu A,Tudora A,Bota S

    更新日期:2011-03-01 00:00:00

  • The HBV DNA cutoff value for discriminating patients with HBeAgnegative chronic hepatitis B from inactive carriers.

    abstract:BACKGROUND:Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions. OBJECTIVES:To determine a strategy for discriminating patients with HBeAg-negative CHB fr...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Kim ES,Seo YS,Keum B,Kim JH,A H,Yim HJ,Kim YS,Jeen YT,Lee HS,Chun HJ,Um SH,Duck Kim C,Ryu HS

    更新日期:2011-05-01 00:00:00

  • LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes.

    abstract:BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15(5)2015.28473

    authors: Liu Y,Zou Z,Zhu B,Hu Z,Zeng P,Wu L

    更新日期:2015-05-23 00:00:00

  • Persistence of HBV Vaccine's Protection and Response to Hepatitis B Booster Immunization in 5- to 7-Year-Old Children in the Kohgiloyeh and Boyerahmad Province, Iran.

    abstract:BACKGROUND AND AIMS:The duration of the protection of hepatitis B vaccination for infants and the necessity of a booster dose administration is unknown. The aim of the present study was to evaluate the persistence of seroprotection after hepatitis B virus (HBV) vaccination in order to determine the necessity of a singl...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Yazdanpanah B,Safari M,Yazdanpanah S

    更新日期:2010-01-01 00:00:00

  • The Distribution of Hepatitis C Virus Genotypes in Middle Eastern Countries: A Systematic Review and Meta-Analysis.

    abstract:CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章,评审

    doi:10.5812/hepatmon.40357

    authors: Ghaderi-Zefrehi H,Gholami-Fesharaki M,Sharafi H,Sadeghi F,Alavian SM

    更新日期:2016-08-23 00:00:00

  • Prognostic values of fluctuations in serum levels of alanine transaminase in inactive carrier state of HBV infection.

    abstract:BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.17537

    authors: Farzi H,Ebrahimi Daryani N,Mehrnoush L,Salimi S,Alavian SM

    更新日期:2014-05-01 00:00:00

  • HAV Immunity in Iranian Medical Students.

    abstract:BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.26219

    authors: Hosseini Shokouh SJ,Dadashi A,Abiri M,Zohrevand I,Eshraghian A,Khoshdel A,Heidari B,Khoshkish S

    更新日期:2015-03-31 00:00:00

  • Epidemiology of hepatitis B in the reproductive-age female farmworkers of southeastern Turkey.

    abstract:BACKGROUND:There are limited data on the prevalence of the hepatitis B virus (HBV) infection in the agricultural population worldwide. OBJECTIVES:This study aimed to determine the prevalence of HBV infection and associated risk factors in the reproductive-age female farmworker. MATERIALS AND METHODS:This cross-sectio...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.22120

    authors: Yentur Doni N,Simsek Z,Keklik Z,Gurses G,Zeyrek FY

    更新日期:2014-11-23 00:00:00

  • Evaluation of the effects of oral N-acetylcysteine and a placebo in paraclinical and oxidative stress parameters of patients with chronic hepatitis B.

    abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Shohrati M,Dermanaki F,Babaei F,Alavian SM

    更新日期:2010-04-01 00:00:00

  • Evaluating Liver Fibrosis by Transient Elastometry in Patients With HIV-HCV Coinfection and Monoinfection.

    abstract:BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15426

    authors: Brescini L,Orsetti E,Gesuita R,Piraccini F,Marchionni E,Staffolani S,Castelli P,Drenaggi D,Barchiesi F

    更新日期:2014-08-05 00:00:00

  • Hepatitis C viral heterogeneity based on core gene and an attempt to design small interfering RNA against strains resistant to interferon in rawalpindi, pakistan.

    abstract:BACKGROUND:Global prevalence of Hepatitis C Virus (HCV) infection corresponds to about 130 million HCV positive patients worldwide. The only drug that effectively reduces viral load is interferon-α (IFN-α) and currently combination of IFN and ribavirin is the choice for treatment. OBJECTIVES:The present study is aimed...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.6184

    authors: Kanwal S,Mahmood T

    更新日期:2012-06-01 00:00:00

  • Evaluation of prevalence and risk factors of hepatitis g virus infection among hemodialysis patients referred to Iranian army hospitals in tehran during 2012-2013.

    abstract:BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.18322

    authors: Dadmanesh M,Hosseinzadeh M,Keyvani H,Ghorban K,Rahimi M,Hosseinzadeh M,Ranjbar MM

    更新日期:2015-01-01 00:00:00

  • The Clinical Significance of Serum Apoptotic Cytokeratin 18 Neoepitope M30 (CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels in Chronic Hepatitis B Patients with Cirrhosis.

    abstract:BACKGROUND:Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. CK-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apopto...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.10106

    authors: Sumer S,Aktug Demir N,Kölgelier S,Cagkan Inkaya A,Arpaci A,Saltuk Demir L,Ural O

    更新日期:2013-06-26 00:00:00

  • Health related quality of life in Iranian hemodialysis patients with viral hepatitis: changing epidemiology.

    abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.9611

    authors: Rostami Z,Lessan Pezeshki M,Soleimani Najaf Abadi A,Einollahi B

    更新日期:2013-05-30 00:00:00

  • Sequencing and Phylogenetic Study of Partial NS3 Gene of Iranian GB Virus C/Hepatitis G Virus (HGV) Originated From Hemodialysis Patients in Tehran.

    abstract:BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.24173

    authors: Dadmanesh M,Ranjbar MM,Alavian SM,Ghorban K

    更新日期:2015-03-05 00:00:00

  • G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.

    abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.31490

    authors: Suppiah J,Mohd Zain R,Bahari N,Haji Nawi S,Saat Z

    更新日期:2015-10-28 00:00:00

  • Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection.

    abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.28287v2

    authors: Ghaleh Baghi S,Alavian SM,Mehrnoush L,Salimi S

    更新日期:2015-07-22 00:00:00

  • A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan.

    abstract:BACKGROUND:Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. OBJECTIVES:To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world. PATIENTS AND METHODS:We conducted a prosp...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:

    authors: Mumtaz K,Hamid S,Ahmed S,Moatter T,Mushtaq S,Khan A,Mizokami M,Jafri W

    更新日期:2011-01-01 00:00:00

  • Decrease of serum Angiotensin converting enzyme levels upon telbivudine treatment for chronic hepatitis B virus infection and negative correlations between the enzyme levels and estimated glumerular filtration rates.

    abstract:BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.15074

    authors: Liang KH,Chen YC,Hsu CW,Chang ML,Yeh CT

    更新日期:2014-01-31 00:00:00

  • The Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study.

    abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/hepatmon.22649

    authors: Sharafi H,Alavian SM,Behnava B,Pouryasin A,Keshvari M

    更新日期:2014-10-01 00:00:00

  • Liver storage disease in Iran: a ten year study of liver biopsies in Children Medical Center Hospital in Tehran-Iran.

    abstract:BACKGROUND:Liver storage diseases are rare biochemical and inherited diseases that affect multiorgan systems. OBJECTIVES:This study was performed to determine the rate of storage diseases and their types in liver pathology specimens of subjects who were referred to a tertiary pediatric center. PATIENTS AND METHODS:Tw...

    journal_title:Hepatitis monthly

    pub_type: 杂志文章

    doi:10.5812/kowsar.1735143x.718

    authors: Motamed F,Monajemzadeh M,Seifirad S,Ashrafi M,Rasti A,Mahjoub F

    更新日期:2011-08-01 00:00:00