Abstract:
CONTEXT:We briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health. EVIDENCE ACQUISITION:Medline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject, then the most relevant and methodologically sound original studies were selected. RESULTS:HCV infection is associated with poorer health-related quality of life, and physical, mental, and social health. A part of impaired health of these patients is related to cirrhosis, intravenous drug use, co morbid psychiatric disorders, stigmatization, poor social support, alcohol abuse, and interferon treatment. However, HCV itself is also associated with poorer health status particularly in the physical and cognitive domains, which might be related to brain alterations induced by the virus. Interferon treatment is an important cause of depression in HCV patients and sometimes is associated with irritability, manic episode, or acute confusional state. Social health of HCV patients is significantly impaired by stigmatization, poor social support, psychiatric comorbidties, and impaired coping. Psychosocial impairment of HCV patients significantly impairs their treatment adherence. A supportive and nonjudgmental multidisciplinary team is required for optimal management of these patients. CONCLUSIONS:Patients with HCV infection had complex neuropsychiatric and psychosocial problems. These problems are challenges for management of HCV infection, affect the patient's care significantly, and might alter the course of the disease. A multidisciplinary approach, a supportive environment, and a nonjudgmental healthcare team are required for optimal medical and psychosocial management of patients with HCV.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Modabbernia A,Poustchi H,Malekzadeh Rdoi
10.5812/hepatmon.8340subject
Has Abstractpub_date
2013-01-01 00:00:00pages
e8340issue
1eissn
1735-143Xissn
1735-3408journal_volume
13pub_type
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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更新日期:2016-04-05 00:00:00
abstract:BACKGROUND AND AIMS:The duration of the protection of hepatitis B vaccination for infants and the necessity of a booster dose administration is unknown. The aim of the present study was to evaluate the persistence of seroprotection after hepatitis B virus (HBV) vaccination in order to determine the necessity of a singl...
journal_title:Hepatitis monthly
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journal_title:Hepatitis monthly
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abstract:BACKGROUND:In spite of dozens of clinical trials to establish effective therapeutic and/or preventive vaccine to resolve HCV infection, no real vaccine has been proved to date. Genetic vaccines based on replication-defective adenoviruses have proved to elicit strong and long lasting T-cell responses against a number of...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.6130
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Treatment of hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin (RBV) is associated with adverse events, which may affect the patient's adherence to the treatment regimen and the treatment efficacy. OBJECTIVES:The aim of this study was to assess the sustained viral response (SVR) and inte...
journal_title:Hepatitis monthly
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journal_title:Hepatitis monthly
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更新日期:2014-08-17 00:00:00
abstract:BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...
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pub_type: 杂志文章
doi:10.5812/hepatmon.15426
更新日期:2014-08-05 00:00:00
abstract:BACKGROUND:Malnutrition is the most common cause of immune deficiency. It results in reduced secretion of T-cells and B-cell-stimulating factors leading to declining of special immunoglobulins. On the other hand, hepatitis B, as a major world health problem, can be prevented effectively by vaccination. Three doses of h...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7048
更新日期:2013-02-03 00:00:00
abstract:BACKGROUND:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. OBJECTIVES:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. PATIENTS AN...
journal_title:Hepatitis monthly
pub_type: 杂志文章
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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更新日期:2013-05-11 00:00:00
abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.34432
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.14476
更新日期:2014-01-23 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.5945
更新日期:2012-10-01 00:00:00
abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.7359
更新日期:2012-11-01 00:00:00
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journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.17822
更新日期:2014-06-08 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7650
更新日期:2012-12-01 00:00:00
abstract:BACKGROUNDS:Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection. OBJECTIVES:The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients. PATIENTS AN...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.29183
更新日期:2015-08-30 00:00:00
abstract:BACKGROUND:Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. OBJECTIVES:We aimed at developing a new panel of surrogate biomarker...
journal_title:Hepatitis monthly
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doi:10.5812/hepatmon.10810
更新日期:2013-06-16 00:00:00
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更新日期:2015-03-05 00:00:00
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journal_title:Hepatitis monthly
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更新日期:2014-02-25 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15(5)2015.28473
更新日期:2015-05-23 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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更新日期:2014-11-23 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...
journal_title:Hepatitis monthly
pub_type:
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更新日期:2016-10-30 00:00:00
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journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Nearly 0.5% of Iranians are infected with HCV. Peginterferon-alpha-2a and Peginterferon-alpha-2b are the two available types of interferon for the treatment of hepatitis C. Comparing the results of these two treatments is still a challenge. OBJECTIVES:The aim of this study was to compare the results of Pegi...
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更新日期:2015-09-29 00:00:00