Abstract:
:Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively.
journal_name
Hepat Monjournal_title
Hepatitis monthlyauthors
Alavian SM,Miri SMsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
67-8issue
2eissn
1735-143Xissn
1735-3408journal_volume
11pub_type
杂志文章abstract:BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.34432
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions. OBJECTIVES:To determine a strategy for discriminating patients with HBeAg-negative CHB fr...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31906
更新日期:2015-11-28 00:00:00
abstract:BACKGROUND AND AIMS:The duration of the protection of hepatitis B vaccination for infants and the necessity of a booster dose administration is unknown. The aim of the present study was to evaluate the persistence of seroprotection after hepatitis B virus (HBV) vaccination in order to determine the necessity of a singl...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. OBJECTIVES:To determine and compare the distribution of HBV genotypes and genomic variations in Pakistan to other parts of the world. PATIENTS AND METHODS:We conducted a prosp...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.32692
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11447
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:Reversibility of advanced fibrosis after HCV-clearance is an important goal of therapy. OBJECTIVES:Measuring liver stiffness (LS) by transient elastography (TE) might be helpful in this setting. PATIENTS AND METHODS:We evaluated 104 patients with biopsy-proven chronic hepatitis C (CHC) and sustained virolo...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7176
更新日期:2013-05-11 00:00:00
abstract:BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.28751
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.22649
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The treatment of chronic hepatitis B (CHB) is a challenging problem today, and previous study has shown that oxidative stress causes the collective pathophysiological conditions of many hepatopathies, so other new therapeutic approaches are needed. Hence, in this study the paraclinical and oxidative...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.31490
更新日期:2015-10-28 00:00:00
abstract:CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...
journal_title:Hepatitis monthly
pub_type: 杂志文章,评审
doi:10.5812/hepatmon.13162
更新日期:2013-08-25 00:00:00
abstract:BACKGROUND:Global prevalence of Hepatitis C Virus (HCV) infection corresponds to about 130 million HCV positive patients worldwide. The only drug that effectively reduces viral load is interferon-α (IFN-α) and currently combination of IFN and ribavirin is the choice for treatment. OBJECTIVES:The present study is aimed...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.6184
更新日期:2012-06-01 00:00:00
abstract:CONTEXT:Hepatitis B vaccination of hemodialysis patients is performed all over the world. There are also recommendations from world health organizations to vaccinate patients with chronic kidney disease (CKD) prior dialysis commencement, but the implementation of a hepatitis B vaccination program is less common and not...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.7359
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15426
更新日期:2014-08-05 00:00:00
abstract:BACKGROUND:Chronic viral hepatitis can be evaluated using invasive or noninvasive methods. OBJECTIVES:The aim of this study was to evaluate liver stiffness in inactive HBsAg carriers compared with normal subjects and determine if it is influenced by viral load in these patients. PATIENTS AND METHODS:We prospectively ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:There are surprisingly a few studies that evaluate the impact of chronic viral hepatitis, which is common in HD (hemodialysis) patients, on HRQOL (health related quality of life). OBJECTIVES:We conducted a study to evaluate the impact of chronic viral hepatitis on HRQOL and to compare their HRQOL with non-i...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.9611
更新日期:2013-05-30 00:00:00
abstract:BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.39097
更新日期:2016-06-28 00:00:00
abstract:BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.40492
更新日期:2016-10-02 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.28287v2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15(5)2015.18811
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.37447
更新日期:2016-04-05 00:00:00
abstract:BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.24635
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.15900
更新日期:2014-02-25 00:00:00
abstract:INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...
journal_title:Hepatitis monthly
pub_type:
doi:10.5812/hepatmon.41933
更新日期:2016-10-30 00:00:00
abstract:BACKGROUND:Zinc deficiency has been reported frequently in hepatitis C patients in the literature. Furthermore, a decrease in zinc level has been shown in beta thalassemia major as well. Iranians consume a large amount of phytate in their regimens which can bind with zinc and decrease its gastrointestinal absorption. ...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.11138
更新日期:2013-08-12 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV) are transmitted by blood transfusion. Thus, hemodialysis (HD) patients are more prone to become the carriers of these infections due to their treatment demands. OBJECTIVES:The aim of this study was to assess the prevale...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.32971
更新日期:2016-01-23 00:00:00
abstract:BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.17537
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:There are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (NAFLD) in different populations. However, the existing literature lacks powerful studies addressing the factors which may predict the severity of NAFLD. OBJECTIVES:In the current study, we a...
journal_title:Hepatitis monthly
pub_type: 杂志文章
doi:10.5812/hepatmon.6860
更新日期:2012-11-01 00:00:00