Abstract：
:The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitively not as advanced as monkeys and humans. Therefore, they are an interesting species in the evolutionary hierarchy for probing the comparative functions of the DMN across species. In this study, we sought to know whether the DMN, and consequently its functions such as self-referential processing, are exclusive to humans/monkeys or can we also observe the DMN in animals such as dogs. To address this issue, resting state functional MRI data from the brains of lightly sedated dogs and unconstrained and fully awake dogs were acquired, and ICA and SCA were performed for identifying the DMN. Since anesthesia can alter resting state networks, confirming our results in awake dogs was essential. Awake dog imaging was accomplished by training the dogs to keep their head still using reinforcement behavioral adaptation techniques. We found that the anterior (such as anterior cingulate and medial frontal) and posterior regions (such as posterior cingulate) of the DMN were dissociated in both awake and anesthetized dogs.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Kyathanahally SP,Jia H,Pustovyy OM,Waggoner P,Beyers R,Schumacher J,Barrett J,Morrison EE,Salibi N,Denney TS,Vodyanoy VJ,Deshpande Gdoi
10.1007/s00429-013-0700-xsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
1063-76issue
2eissn
1863-2653issn
1863-2661journal_volume
220pub_type
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