Abstract：
:Recently, there have been great interests for computer-aided diagnosis of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). Unlike the previous methods that considered simple low-level features such as gray matter tissue volumes from MRI, and mean signal intensities from PET, in this paper, we propose a deep learning-based latent feature representation with a stacked auto-encoder (SAE). We believe that there exist latent non-linear complicated patterns inherent in the low-level features such as relations among features. Combining the latent information with the original features helps build a robust model in AD/MCI classification, with high diagnostic accuracy. Furthermore, thanks to the unsupervised characteristic of the pre-training in deep learning, we can benefit from the target-unrelated samples to initialize parameters of SAE, thus finding optimal parameters in fine-tuning with the target-related samples, and further enhancing the classification performances across four binary classification problems: AD vs. healthy normal control (HC), MCI vs. HC, AD vs. MCI, and MCI converter (MCI-C) vs. MCI non-converter (MCI-NC). In our experiments on ADNI dataset, we validated the effectiveness of the proposed method, showing the accuracies of 98.8, 90.7, 83.7, and 83.3 % for AD/HC, MCI/HC, AD/MCI, and MCI-C/MCI-NC classification, respectively. We believe that deep learning can shed new light on the neuroimaging data analysis, and our work presented the applicability of this method to brain disease diagnosis.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Suk HI,Lee SW,Shen D,Alzheimer’s Disease Neuroimaging Initiative.doi
10.1007/s00429-013-0687-3subject
Has Abstractpub_date
2015-03-01 00:00:00pages
841-59issue
2eissn
1863-2653issn
1863-2661journal_volume
220pub_type
杂志文章abstract：:Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1768-0
更新日期：2019-01-01 00:00:00
abstract：:The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research wa...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0595-6
更新日期：2014-09-01 00:00:00
abstract：:Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-base...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0485-3
更新日期：2014-01-01 00:00:00
abstract：:Projections from the prefrontal cortex (PFC) to the amygdala (AMG) regulate affective behaviors in a manner that is modulated by dopamine (DA). Although PFC and DA inputs overlap within the basolateral nucleus (BLA) and intercalated cell masses (ICMs), the spatial relationship between these afferents has not been inve...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0180-6
更新日期：2008-09-01 00:00:00
abstract：:Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0921-7
更新日期：2016-01-01 00:00:00
abstract：:The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0530-x
更新日期：2014-03-01 00:00:00
abstract：:Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-010-0275-8
更新日期：2010-08-01 00:00:00
abstract：:The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02188-2
更新日期：2021-01-01 00:00:00
abstract：:The paraventricular nucleus of the thalamus (PVT) is part of a group of midline and intralaminar thalamic nuclei implicated in arousal and attention. Recent research points to anatomical and functional differences between the anterior (aPVT) and posterior PVT (pPVT). The present study re-examines the main sources of b...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0360-7
更新日期：2012-04-01 00:00:00
abstract：:The organization of the serotonergic system, one of the most important neurotransmitter systems in the brain, has been carefully analyzed in most vertebrate groups, and major shared characteristics have been described, although traits particular to each vertebrate class have also been found. The present study is the f...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0661-0
更新日期：2015-01-01 00:00:00
abstract：:Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0778-9
更新日期：2015-07-01 00:00:00
abstract：:Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of biological organization (genetic, molecular, biochemi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1375-5
更新日期：2017-08-01 00:00:00
abstract：:There is limited information on the role of GABA type A receptors (GABAARs) containing α1, α5 and γ2 subunits in learning and memory. Here, we assessed the possible role of such receptors in spatial learning using the multiple T-maze (MTM) paradigm. C57BL/6J mice were trained in the MTM which induced elevated levels o...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1233-x
更新日期：2017-01-01 00:00:00
abstract：:We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1071-2
更新日期：2016-06-01 00:00:00
abstract：:The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1265-2
更新日期：2017-04-01 00:00:00
abstract：:Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0981-8
更新日期：2016-04-01 00:00:00
abstract：:The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0815-8
更新日期：2015-09-01 00:00:00
abstract：:Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1158-9
更新日期：2016-11-01 00:00:00
abstract：:Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1769-z
更新日期：2019-01-01 00:00:00
abstract：:World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1322-x
更新日期：2017-07-01 00:00:00
abstract：:Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1330-x
更新日期：2017-07-01 00:00:00
abstract：:Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0229-1
更新日期：2009-12-01 00:00:00
abstract：:The amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field extern...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02201-8
更新日期：2021-01-30 00:00:00
abstract：:The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02104-8
更新日期：2020-09-01 00:00:00
abstract：:The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-019-01835-7
更新日期：2019-04-01 00:00:00
abstract：:Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02086-7
更新日期：2020-06-01 00:00:00
abstract：:The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial deb...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0809-6
更新日期：2015-09-01 00:00:00
abstract：:An account of work performed at the UNA laboratories since 1992 on the detection and description of interlaminar glial processes, is presented. The incidental observation (serendipity) of longer than expected glial processes in the superficial layers of the cerebral cortex in hemiparkinsonian Cebus apella monkeys, was...
journal_title：Brain structure & function
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00429-016-1332-8
更新日期：2017-04-01 00:00:00
abstract：:Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0558-y
更新日期：2014-07-01 00:00:00
abstract：:Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1431-1
更新日期：2017-11-01 00:00:00
