Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.

abstract：:Several studies have begun to demonstrate that contextual memories constitute an important mechanism to guide our attention. Although there is general consensus that the hippocampus is involved in the encoding of contextual memories, it is controversial whether this structure can support implicit forms of contextual m...

journal_title：Brain structure & function

authors： Rosero MA,Winkelmann T,Pohlack S,Cavalli J,Nees F,Flor H

更新日期：2019-07-01 00:00:00

abstract：:Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...

journal_title：Brain structure & function

authors： Palande NV,Biswas S,Jadhao AG

更新日期：2011-03-01 00:00:00

abstract：:Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

journal_title：Brain structure & function

authors： Kellermann T,Scholle R,Schneider F,Habel U

更新日期：2017-03-01 00:00:00

abstract：:The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...

journal_title：Brain structure & function

authors： Zhang CL,Houbaert X,Lepleux M,Deshors M,Normand E,Gambino F,Herzog E,Humeau Y

更新日期：2015-11-01 00:00:00

abstract：:Exercise (physical activity) has been proposed as a treatment for drug addiction. In rodents, voluntary wheel running reduces cocaine and nicotine seeking during extinction, and reinstatement of cocaine seeking triggered by drug-cues. The purpose of this study was to examine the effects of chronic wheel running during...

journal_title：Brain structure & function

authors： Sobieraj JC,Kim A,Fannon MJ,Mandyam CD

更新日期：2016-01-01 00:00:00

abstract：:The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. To...

journal_title：Brain structure & function

authors： Rogers Flattery CN,Rosen RF,Farberg AS,Dooyema JM,Hof PR,Sherwood CC,Walker LC,Preuss TM

更新日期：2020-11-01 00:00:00

abstract：:Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of biological organization (genetic, molecular, biochemi...

journal_title：Brain structure & function

authors： Gonzalez-Riano C,Tapia-González S,García A,Muñoz A,DeFelipe J,Barbas C

更新日期：2017-08-01 00:00:00

abstract：:Using T 1-weighted MRI at two different magnetic field strengths, the enhanced longitudinal relaxivity due to paramagnetic manganese ions in mouse brain in vivo is shown to reflect reduced intracellular mobility. One day after systemic administration of manganese chloride, increases of the longitudinal relaxation rate...

journal_title：Brain structure & function

authors： Watanabe T,Frahm J,Michaelis T

更新日期：2015-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in syna...

journal_title：Brain structure & function

authors： Aerts J,Nys J,Moons L,Hu TT,Arckens L

更新日期：2015-09-01 00:00:00

abstract：:The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...

journal_title：Brain structure & function

authors： Schmitt O,Eipert P,Kettlitz R,Leßmann F,Wree A

更新日期：2016-03-01 00:00:00

abstract：:Despite robust sex differences in behavioral responses to drugs of abuse, relatively little is known about structural sex differences in synaptic connectivity of reward circuits such as in the nucleus accumbens (NAc). Previously, we showed that distal dendritic spine density on medium spiny neurons in the NAc is highe...

journal_title：Brain structure & function

authors： Wissman AM,May RM,Woolley CS

更新日期：2012-04-01 00:00:00

abstract：:Children born very preterm (VPT) at less than 32 weeks' gestational age (GA) are prone to disrupted white matter maturation and impaired cognitive development. The aims of the present study were to identify differences in white matter microstructure and connectivity of children born VPT compared to term-born children,...

journal_title：Brain structure & function

authors： Young JM,Vandewouw MM,Morgan BR,Smith ML,Sled JG,Taylor MJ

更新日期：2018-06-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) has become a valuable tool to investigate white matter integrity in the brain. DTI also gives contrast in gray matter, which has been relatively little explored in studies assessing post-injury structural abnormalities. The present study was designed to compare white and gray matter reor...

journal_title：Brain structure & function

authors： Sierra A,Laitinen T,Gröhn O,Pitkänen A

更新日期：2015-03-01 00:00:00

abstract：:Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using ...

journal_title：Brain structure & function

authors： Takahashi H,Brasnjevic I,Rutten BP,Van Der Kolk N,Perl DP,Bouras C,Steinbusch HW,Schmitz C,Hof PR,Dickstein DL

更新日期：2010-03-01 00:00:00

abstract：:The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...

journal_title：Brain structure & function

authors： Bellier JP,Xie Y,Farouk SM,Sakaue Y,Tooyama I,Kimura H

更新日期：2017-09-01 00:00:00

abstract：:The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

journal_title：Brain structure & function

authors： Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

更新日期：2014-03-01 00:00:00

abstract：:The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...

journal_title：Brain structure & function

authors： Lopez-Huerta VG,Nakano Y,Bausenwein J,Jaidar O,Lazarus M,Cherassse Y,Garcia-Munoz M,Arbuthnott G

更新日期：2016-04-01 00:00:00

abstract：:Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...

journal_title：Brain structure & function

authors： Kong V,Devenyi GA,Gallino D,Ayranci G,Germann J,Rollins C,Chakravarty MM

更新日期：2018-09-01 00:00:00

abstract：:To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...

journal_title：Brain structure & function

authors： Demertzi A,Van Ombergen A,Tomilovskaya E,Jeurissen B,Pechenkova E,Di Perri C,Litvinova L,Amico E,Rumshiskaya A,Rukavishnikov I,Sijbers J,Sinitsyn V,Kozlovskaya IB,Sunaert S,Parizel PM,Van de Heyning PH,Laureys S,Wuyts F

更新日期：2016-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...

journal_title：Brain structure & function

authors： Chen K,Northington FJ,Martin LJ

更新日期：2010-03-01 00:00:00

abstract：:Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wa...

journal_title：Brain structure & function

authors： Hay YA,Andjelic S,Badr S,Lambolez B

更新日期：2015-11-01 00:00:00

abstract：:Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...

journal_title：Brain structure & function

authors： Zhu W,Ge X,Gao P,Li M,Guan Y,Guan X

更新日期：2018-05-01 00:00:00

abstract：:Almost 30 years ago, the monoclonal antibody Py was developed to detect pyramidal neurons in the CA3 region of the rat hippocampus. The utility of this antibody quickly expanded when several groups discovered that it could be used to identify very specific populations of neurons in the normal, developing, and diseased...

journal_title：Brain structure & function

authors： Fuller HR,Marani L,Holt I,Woodhams PL,Webb MM,Gates MA

更新日期：2017-03-01 00:00:00

abstract：:The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...

journal_title：Brain structure & function

authors： González-Palomares E,López-Jury L,García-Rosales F,Hechavarria JC

更新日期：2021-01-01 00:00:00

abstract：:The telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major domains: striatum, pallidum, diagonal area and preoptic area (Puelles et al. 2013; Allen Developin...

journal_title：Brain structure & function

authors： Puelles L,Morales-Delgado N,Merchán P,Castro-Robles B,Martínez-de-la-Torre M,Díaz C,Ferran JL

更新日期：2016-07-01 00:00:00

abstract：:Growing evidence indicates that physical exercise increases hippocampal volume. This has consistently been shown in mice and men using magnetic resonance imaging. On the other hand, histological studies have reported profound alterations on a cellular level including increased adult hippocampal neurogenesis after exer...

journal_title：Brain structure & function

authors： Biedermann SV,Fuss J,Steinle J,Auer MK,Dormann C,Falfán-Melgoza C,Ende G,Gass P,Weber-Fahr W

更新日期：2016-04-01 00:00:00

abstract：:The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respe...

journal_title：Brain structure & function

authors： Sgambato-Faure V,Worbe Y,Epinat J,Féger J,Tremblay L

更新日期：2016-01-01 00:00:00

abstract：:Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...

journal_title：Brain structure & function

authors： van Kerkhof LW,Trezza V,Mulder T,Gao P,Voorn P,Vanderschuren LJ

更新日期：2014-07-01 00:00:00

abstract：:Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chr...

journal_title：Brain structure & function

authors： Pinto V,Costa JC,Morgado P,Mota C,Miranda A,Bravo FV,Oliveira TG,Cerqueira JJ,Sousa N

更新日期：2015-03-01 00:00:00

abstract：:Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...

journal_title：Brain structure & function

authors： Uemura Y,Haque T,Sato F,Tsutsumi Y,Ohara H,Oka A,Furuta T,Bae YC,Yamashiro T,Tachibana Y,Yoshida A

更新日期：2020-09-01 00:00:00