Abstract:
:Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in synaptic plasticity, hippocampus-dependent learning and neuronal development and migration in the cerebellum. However, the function(s) of this enzyme in the neocortex is understudied. Therefore, we explored the phenotypical characteristics of the neuronal architecture and the capacity for experience-dependent cortical plasticity in the visual cortex of adult MMP-3-deficient (MMP-3(-/-)) mice. Golgi-Cox stainings revealed a significant reduction in apical dendritic length and an increased number of apical obliques for layer V pyramidal neurons in the visual cortex of adult MMP-3(-/-) mice compared to wild-type (WT) animals. In addition, a significant upregulation of both phosphorylated and non-phosphorylated neurofilament protein (NF)-high, phosphorylated NF-medium, NF-low and α-internexin was detected in the visual cortex of MMP-3(-/-) mice. To assess the effect of MMP-3 deficiency on cortical plasticity, we monocularly enucleated adult MMP-3(-/-) mice and analyzed the reactivation of the contralateral visual cortex 7 weeks post-enucleation. In contrast to previous results in C57Bl/6J adult mice, activity remained confined to the binocular zone and did not expand into the monocular regions indicative for an aberrant open-eye potentiation. Permanent hypoactivity in the monocular cortex lateral and medial to V1 also indicated a lack of cross-modal plasticity. These observations demonstrate that genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Aerts J,Nys J,Moons L,Hu TT,Arckens Ldoi
10.1007/s00429-014-0819-4subject
Has Abstractpub_date
2015-09-01 00:00:00pages
2675-89issue
5eissn
1863-2653issn
1863-2661journal_volume
220pub_type
杂志文章abstract::Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1330-x
更新日期:2017-07-01 00:00:00
abstract::The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0882-x
更新日期:2015-11-01 00:00:00
abstract::The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. To...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02139-x
更新日期:2020-11-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Early-life sleep deprivation (ESD) is a serious condition with severe metabolic sequelae. The pineal hormone melatonin plays an important role in homeostatic regulation of metabolic function. Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstrea...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0716-x
更新日期:2015-03-01 00:00:00
abstract::The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02104-8
更新日期:2020-09-01 00:00:00
abstract::To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02047-0
更新日期:2020-05-01 00:00:00
abstract::The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0572-0
更新日期:2014-07-01 00:00:00
abstract::The transcription factor Pax6 has been reported to specify neural progenitor cell fates during development and maintain neuronal commitments in the adult. The spatiotemporal patterns of Pax6 expression were examined in sagittal and horizontal sections of the embryonic, postnatal, and adult brains using immunohistochem...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0397-2
更新日期:2013-03-01 00:00:00
abstract::The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1000-4
更新日期:2016-04-01 00:00:00
abstract::Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1748-4
更新日期:2018-12-01 00:00:00
abstract::Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01866-0
更新日期:2019-06-01 00:00:00
abstract::The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0209-5
更新日期:2009-09-01 00:00:00
abstract::Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0778-9
更新日期:2015-07-01 00:00:00
abstract::Understanding the intricate three-dimensional relationship between fiber bundles and subcortical nuclei is not a simple task. It is of paramount importance in neurosciences, especially in the field of functional neurosurgery. The current methods for in vivo and post mortem fiber tract visualization have shortcomings a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02187-3
更新日期:2021-01-03 00:00:00
abstract::The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial deb...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0809-6
更新日期:2015-09-01 00:00:00
abstract::Pigeons are classic animal models for learning, memory, and cognition. The majority of the current understanding about avian neurobiology outside of the domain of the song system has been established using pigeons. Since MRI represents an increasingly relevant tool for comparative neuroscience, a 3-dimensional MRI-bas...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0400-y
更新日期:2013-01-01 00:00:00
abstract::Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0275-8
更新日期:2010-08-01 00:00:00
abstract::The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0815-8
更新日期:2015-09-01 00:00:00
abstract::Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0524-8
更新日期:2014-03-01 00:00:00
abstract::We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1071-2
更新日期:2016-06-01 00:00:00
abstract::Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01881-1
更新日期:2019-06-01 00:00:00
abstract::Normally, we are aware that our arms and legs belong to us and not to someone else. However, some stroke patients with hemiparesis/-plegia after right-sided stroke show a disturbed sensation of limb ownership and a disturbed self-awareness of actions and such patients with anosognosia for hemiparesis/plegia typically ...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-010-0250-4
更新日期:2010-06-01 00:00:00
abstract::Using T 1-weighted MRI at two different magnetic field strengths, the enhanced longitudinal relaxivity due to paramagnetic manganese ions in mouse brain in vivo is shown to reflect reduced intracellular mobility. One day after systemic administration of manganese chloride, increases of the longitudinal relaxation rate...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0742-8
更新日期:2015-01-01 00:00:00
abstract::Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1461-8
更新日期:2017-12-01 00:00:00
abstract::Neuronal replacement in the pallial song control nucleus HVC of adult zebra finches constitutes an interesting case of homeostatic plasticity; in spite of continuous addition and attrition of neurons in ensembles that code song elements, adult song remains remarkably invariant. New neurons migrate into HVC and later s...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1006-y
更新日期:2016-05-01 00:00:00
abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0160-2
更新日期:2007-12-01 00:00:00
abstract::Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1142-4
更新日期:2016-11-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0226-4
更新日期:2010-03-01 00:00:00
abstract::The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1716-z
更新日期:2018-11-01 00:00:00