Abstract:
:The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patients with chronic post-stroke aphasia. Principal components analysis was used to distil orthogonal measures of phonological and semantic processing, which were then related to reading performance and the underlying lesion distributions using voxel-based correlational methodology. Concrete word reading involved both a ventral semantic pathway, and inferior and anterior aspects of the dorsal phonological pathway. Abstract word reading overlapped with the ventral semantic pathway but also drew more extensively on the superior and posterior aspects of the dorsal phonological pathway. Nonword reading was related to phonological processing along the dorsal pathway and was also supported by a more superior set of regions previously associated with speech motor output. The use of continuous measures of behavioural performance and neural integrity allowed us to elucidate for the first time both the lesion and behavioural correlates for the semantic and phonological components of the primary systems hypothesis and to extend these by identifying the importance of an additional dorsal speech motor output system. These results provide a target for future neuroanatomically constrained computational models of reading.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Woollams AM,Halai A,Lambon Ralph MAdoi
10.1007/s00429-018-1716-zsubject
Has Abstractpub_date
2018-11-01 00:00:00pages
3769-3786issue
8eissn
1863-2653issn
1863-2661pii
10.1007/s00429-018-1716-zjournal_volume
223pub_type
杂志文章abstract::We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) usin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0496-0
更新日期:2014-01-01 00:00:00
abstract::The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitive...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0700-x
更新日期:2015-03-01 00:00:00
abstract::Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-base...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0485-3
更新日期:2014-01-01 00:00:00
abstract::The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1471-6
更新日期:2018-01-01 00:00:00
abstract::The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, by systemic or local administration to the pedunculopontine nucleus, can both influence sleep. We previously demonstra...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1214-0
更新日期:2017-01-01 00:00:00
abstract::Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specifi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1682-5
更新日期:2018-09-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1748-4
更新日期:2018-12-01 00:00:00
abstract::The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making. Both structures strongly innervate the lateral hypothalamus (LHA), an important component of the networks underlying the control of feedin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1081-0
更新日期:2016-07-01 00:00:00
abstract::Diffusion-weighted magnetic resonance spectroscopy of brain metabolites offers unique access to compartment-specific microstructural information on neural tissue. Here, we investigated in detail the diffusion characteristics of the neuronal/axonal markers N-acetylaspartate + N-acetyl aspartyl glutamate (tNAA) in a sma...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0600-0
更新日期:2014-09-01 00:00:00
abstract::Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0292-7
更新日期:2011-03-01 00:00:00
abstract::Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0218-4
更新日期:2009-10-01 00:00:00
abstract::Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1553-5
更新日期:2018-04-01 00:00:00
abstract::Serotonergic cells are among the earliest neurons to be born in the developing central nervous system and serotonin is known to regulate the development of the nervous system. One of the major targets of the activity of serotonergic cells is the serotonin 1A receptor (5-HT1A), an ancestral archetypical serotonin recep...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0461-y
更新日期:2013-09-01 00:00:00
abstract::Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0981-8
更新日期:2016-04-01 00:00:00
abstract::A recent virtual-lesion study using inhibitory repetitive transcranial magnetic stimulation (rTMS) confirmed the causal behavioral relevance of the precuneus in the evaluation of one's own memory performance (aka mnemonic metacognition). This study's goal is to elucidate how these TMS-induced neuromodulatory effects m...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01909-6
更新日期:2019-09-01 00:00:00
abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1487-y
更新日期:2018-01-01 00:00:00
abstract::Cytoarchitectonic characterization of borders is necessary for stereological studies (e.g., total cell number estimation), in which particular cortical areas have to be defined. In this study, cytoarchitectonic characteristics are described and illustrated for the rat ventral or orbital frontal cortical areas, i.e., t...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0164-y
更新日期:2008-02-01 00:00:00
abstract::Glutamatergic afferents from the cerebral cortex are the main excitatory drive of striatal projection neurons. The metabotropic glutamate receptor 4 (mGluR4) presynaptically modulates transmission at corticostriatal synapses, and is considered as a potent drug target for Parkinson's disease and other brain disorders. ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1187-z
更新日期:2016-12-01 00:00:00
abstract::Distribution of bromodeoxyuridine immunoreactive (BrdU-IR) cell nuclei was analyzed at proximal and remote cortical sites in adult Cebus apella monkeys after a programmed surgical lesion placed either in the prefrontal or in the striate cerebral cortex. Increased GFAP-IR and vimentin-IR astrocytes, as well as Isolecti...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0356-3
更新日期:2012-04-01 00:00:00
abstract::The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1447-6
更新日期:2017-12-01 00:00:00
abstract::Forebrain serotonin relevant for many psychological disorders arises in the hindbrain, primarily within the dorsal and median raphe nuclei (DR and MR). These nuclei are heterogeneous, containing several distinct groups of serotonin neurons. Here, new insight into the afferent and efferent connectivity of these areas i...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-015-1176-7
更新日期:2016-09-01 00:00:00
abstract::The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preferenc...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02096-5
更新日期:2020-07-01 00:00:00
abstract::The organization of the serotonergic system, one of the most important neurotransmitter systems in the brain, has been carefully analyzed in most vertebrate groups, and major shared characteristics have been described, although traits particular to each vertebrate class have also been found. The present study is the f...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0661-0
更新日期:2015-01-01 00:00:00
abstract::The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respe...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0911-9
更新日期:2016-01-01 00:00:00
abstract::The neural underpinnings of human emotional expression are thought to be unevenly distributed among the two brain hemispheres. However, little is known on the anatomy supporting this claim, particularly in the cerebral white matter. Here, we explored the relationship between hemi-face dominance in emotional expression...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02040-7
更新日期:2020-05-01 00:00:00
abstract::A loss-of-function polymorphism in the α5 nicotinic acetylcholine receptor (nAChR) subunit gene has been linked to both drug abuse and schizophrenia. The α5 nAChR subunit is strategically positioned in the prefrontal cortex (PFC), where a loss-of-function in this subunit may contribute to cognitive disruptions in both...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1601-1
更新日期:2018-03-01 00:00:00
abstract::Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01872-2
更新日期:2019-06-01 00:00:00
abstract::Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1768-0
更新日期:2019-01-01 00:00:00
abstract::The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial deb...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0809-6
更新日期:2015-09-01 00:00:00