Abstract：
:To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffusion MRI tractography data to investigate the organisational principles of the human temporal association cortex. We identify three overlapping gradients of connectivity that are, for the most part, consistent across hemispheres. The first gradient reveals an inferior-superior organisation of predominantly longitudinal tracts and separates visual and auditory unimodal and multimodal cortices. The second gradient radiates outward from the posterior middle temporal cortex with the arcuate fascicle as a distinguishing feature; the third gradient is concentrated in the anterior temporal lobe and emanates towards its posterior end. We describe the functional relevance of each of these gradients through the meta-analysis of data from the neuroimaging literature. Together, these results unravel the overlapping dimensions of structural organization of the human temporal cortex and provide a framework underlying its functional multiplicity.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Blazquez Freches G,Haak KV,Bryant KL,Schurz M,Beckmann CF,Mars RBdoi
10.1007/s00429-020-02047-0subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1245-1260issue
4eissn
1863-2653issn
1863-2661pii
10.1007/s00429-020-02047-0journal_volume
225pub_type
杂志文章abstract：:In the neocortex, large layer 5B pyramidal neurons implement a high-density firing code. In contrast, other subtypes of pyramidal neurons, including those in layer 2/3, are functionally characterized by their sparse firing rate. Here, we investigate the synaptic basis of this behavior by comparing the properties of th...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01842-8
更新日期：2019-05-01 00:00:00
abstract：:Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid (GC) release from the adrenal. These hormones exert numerous effects in the body and brain and bind to a.o. glucocorticoid receptors (GR) expressed in the limbic system, including the hippocampus and amygdala. Hyp...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0589-4
更新日期：2014-09-01 00:00:00
abstract：:Some of the known sex differences in white matter emerge during adolescence. Here, we replicate and extend our previous findings of sex differences in the structure of the corticospinal tract (Perrin et al. 2009; Hervé et al. 2009). In a large normative sample of adolescents, we observed age × sex interactions in the ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0956-9
更新日期：2016-03-01 00:00:00
abstract：:Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1158-9
更新日期：2016-11-01 00:00:00
abstract：:Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1278-x
更新日期：2017-04-01 00:00:00
abstract：:Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigate...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01874-0
更新日期：2019-06-01 00:00:00
abstract：:Ambulatory locomotion in the rodent is robustly activated by unilateral infusions into the basal forebrain of type A gamma-aminobutyric acid receptor antagonists, such as bicuculline and picrotoxin. The present study was carried out to better localize the neuroanatomical substrate(s) underlying this effect. To accompl...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0514-x
更新日期：2014-03-01 00:00:00
abstract：:Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1142-4
更新日期：2016-11-01 00:00:00
abstract：:Manual volumetric measurement of the brain's frontal lobe and its subregions from magnetic resonance images (MRIs) is an established method for researching neural correlates of clinical disorders or cognitive functions. However, there is no consensus between methods used to identify relevant boundaries of a given regi...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-013-0527-5
更新日期：2014-01-01 00:00:00
abstract：:How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-007-0160-2
更新日期：2007-12-01 00:00:00
abstract：:The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1705-2
更新日期：2018-11-01 00:00:00
abstract：:Using sinusoidal oscillations of linear acceleration along both the horizontal and vertical planes to stimulate otolith organs in the inner ear, we charted the postnatal time at which responsive neurons in the rat inferior olive (IO) first showed Fos expression, an indicator of neuronal recruitment into the otolith ci...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0432-3
更新日期：2013-07-01 00:00:00
abstract：:Neuroligins are transmembrane cell adhesion proteins with a key role in the regulation of excitatory and inhibitory synapses. Based on previous in vitro and ex vivo studies, neuroligin-1 (NL1) has been suggested to play a selective role in the function of glutamatergic synapses. However, the role of NL1 has not yet be...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0636-1
更新日期：2015-01-01 00:00:00
abstract：:Glutamatergic afferents from the cerebral cortex are the main excitatory drive of striatal projection neurons. The metabotropic glutamate receptor 4 (mGluR4) presynaptically modulates transmission at corticostriatal synapses, and is considered as a potent drug target for Parkinson's disease and other brain disorders. ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1187-z
更新日期：2016-12-01 00:00:00
abstract：:Growing evidence indicates that physical exercise increases hippocampal volume. This has consistently been shown in mice and men using magnetic resonance imaging. On the other hand, histological studies have reported profound alterations on a cellular level including increased adult hippocampal neurogenesis after exer...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0976-5
更新日期：2016-04-01 00:00:00
abstract：:The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1471-6
更新日期：2018-01-01 00:00:00
abstract：:The Ly-6 superfamily of proteins, which affects diverse processes in the immune system, has attracted renewed attention due to the ability of some Ly-6 proteins to bind to and modulate the function of neuronal nicotinic acetylcholine receptors (nAChRs). However, there is a scarcity of knowledge regarding the distribut...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0611-x
更新日期：2014-11-01 00:00:00
abstract：:Emerging data support roles for microRNA (miRNA) in the pathogenesis of various neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine volume. Recent work identified upregulation of miR-134 in experimental and human epilepsy....
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0798-5
更新日期：2015-07-01 00:00:00
abstract：:The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preferenc...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02096-5
更新日期：2020-07-01 00:00:00
abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1514-z
更新日期：2018-03-01 00:00:00
abstract：:Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0229-1
更新日期：2009-12-01 00:00:00
abstract：:Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0778-9
更新日期：2015-07-01 00:00:00
abstract：:Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1691-4
更新日期：2018-09-01 00:00:00
abstract：:Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1251-8
更新日期：2017-03-01 00:00:00
abstract：:The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0815-8
更新日期：2015-09-01 00:00:00
abstract：:Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01908-7
更新日期：2019-09-01 00:00:00
abstract：:Several studies have begun to demonstrate that contextual memories constitute an important mechanism to guide our attention. Although there is general consensus that the hippocampus is involved in the encoding of contextual memories, it is controversial whether this structure can support implicit forms of contextual m...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01887-9
更新日期：2019-07-01 00:00:00
abstract：:The authors have retracted this article Jannesari et al. (2019) because an incorrect version of the article was published in error. The manuscript has been republished as Jannesari et al. (2020). All authors agree to this retraction. ...
journal_title：Brain structure & function
pub_type： 杂志文章,撤回出版物
doi：10.1007/s00429-020-02042-5
更新日期：2020-04-01 00:00:00
abstract：:The tegmental pedunculopontine nucleus (PPN) is a basal ganglia-related structure that has recently gained renewed interest as a potential surgical target for the treatment of several aspects of Parkinson's disease. However, the underlying anatomical substrates sustaining the choice of the PPN nucleus as a surgical ca...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0317-x
更新日期：2011-11-01 00:00:00
abstract：:AMIGO2, or amphoterin-induced gene and ORF (open reading frame) 2, belongs to the leucine-rich repeats and immunoglobulin superfamilies. The protein is a downstream target of calcium-dependent survival signals and, therefore, promotes neuronal survival. Here, we describe the mRNA distribution pattern of AMIGO2 through...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0387-4
更新日期：2013-01-01 00:00:00
