Synaptic mechanisms underlying the intense firing of neocortical layer 5B pyramidal neurons in response to cortico-cortical inputs.

abstract：:Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...

journal_title：Brain structure & function

authors： Na M,Kim K,Lim HR,Ha CM,Chang S

更新日期：2021-01-01 00:00:00

abstract：:Brain pathology in Friedreich ataxia is characterized by progressive degeneration of nervous tissue in the brainstem, cerebellum and cerebellar peduncles. Evidence of cerebral involvement is however equivocal. This brain imaging study investigates cerebello-cerebral white matter connectivity in Friedreich ataxia with ...

journal_title：Brain structure & function

authors： Zalesky A,Akhlaghi H,Corben LA,Bradshaw JL,Delatycki MB,Storey E,Georgiou-Karistianis N,Egan GF

更新日期：2014-05-01 00:00:00

abstract：:How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...

journal_title：Brain structure & function

authors： Hanson SJ,Hanson C,Halchenko Y,Matsuka T,Zaimi A

更新日期：2007-12-01 00:00:00

abstract：:This study investigates the mechanism of action of spadin, a putative fast-acting peptidic antidepressant (AD) and a functional blocker of the K(+) TREK-1 channel, in relation with the medial prefrontal cortex (mPFC)-dorsal raphé (DRN) serotonergic (5-HT) neurons connectivity. Spadin increased 5-HT neuron firing rate ...

journal_title：Brain structure & function

authors： Moha ou Maati H,Bourcier-Lucas C,Veyssiere J,Kanzari A,Heurteaux C,Borsotto M,Haddjeri N,Lucas G

更新日期：2016-01-01 00:00:00

abstract：:Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...

journal_title：Brain structure & function

authors： Bi AL,Wang Y,Zhang S,Li BQ,Sun ZP,Bi HS,Chen ZY

更新日期：2015-03-01 00:00:00

abstract：:Melatonin, through its different receptors, has pleiotropic functions in mammalian brain. Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated and non-receptor-mediated actions. With recent advancement in neuroanatomical mapping, we may now understand better the localizations o...

journal_title：Brain structure & function

authors： Ng KY,Leong MK,Liang H,Paxinos G

更新日期：2017-09-01 00:00:00

abstract：:The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...

journal_title：Brain structure & function

authors： Huck J,Wanner Y,Fan AP,Jäger AT,Grahl S,Schneider U,Villringer A,Steele CJ,Tardif CL,Bazin PL,Gauthier CJ

更新日期：2019-09-01 00:00:00

abstract：:The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...

journal_title：Brain structure & function

authors： Martinez-Gonzalez C,van Andel J,Bolam JP,Mena-Segovia J

更新日期：2014-07-01 00:00:00

abstract：:A history of intermittent, limited sucrose intake (LSI) attenuates the hypothalamic-pituitary-adrenocortical (HPA) axis stress response, and neuronal activity in the basolateral amygdala (BLA) is necessary for this HPA-dampening. LSI increases the expression of plasticity-associated genes in the BLA; however, the natu...

journal_title：Brain structure & function

authors： Packard AEB,Di S,Egan AE,Fourman SM,Tasker JG,Ulrich-Lai YM

更新日期：2017-12-01 00:00:00

abstract：:Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

journal_title：Brain structure & function

authors： Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

更新日期：2018-11-01 00:00:00

abstract：:Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigate...

journal_title：Brain structure & function

authors： Paik SK,Yoo HI,Choi SK,Bae JY,Park SK,Bae YC

更新日期：2019-06-01 00:00:00

abstract：:Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but ...

journal_title：Brain structure & function

authors： Beste C,Saft C

更新日期：2015-01-01 00:00:00

abstract：:Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...

journal_title：Brain structure & function

authors： Zhu W,Ge X,Gao P,Li M,Guan Y,Guan X

更新日期：2018-05-01 00:00:00

abstract：:Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...

journal_title：Brain structure & function

authors： van Kerkhof LW,Trezza V,Mulder T,Gao P,Voorn P,Vanderschuren LJ

更新日期：2014-07-01 00:00:00

abstract：:The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...

journal_title：Brain structure & function

authors： Bellier JP,Xie Y,Farouk SM,Sakaue Y,Tooyama I,Kimura H

更新日期：2017-09-01 00:00:00

abstract：:The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN). Functionally, NUCB2/nesfatin-1 neurons in the PVN regulate feeding through the hypothalamus and brain st...

journal_title：Brain structure & function

authors： Maejima Y,Kumamoto K,Takenoshita S,Shimomura K

更新日期：2016-12-01 00:00:00

abstract：:The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research wa...

journal_title：Brain structure & function

authors： Jednoróg K,Gawron N,Marchewka A,Heim S,Grabowska A

更新日期：2014-09-01 00:00:00

abstract：:World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...

journal_title：Brain structure & function

authors： Mishra D,Pena-Bravo JI,Leong KC,Lavin A,Reichel CM

更新日期：2017-07-01 00:00:00

abstract：:Reduction in the amount of brain-derived neurotrophic factor (BDNF) in corticostriatal afferents is thought to contribute to the vulnerability of medium spiny striatal neurons in Huntington's disease. In young Bdnf heterozygous ((+/-)) mice, striatal medium spiny neurons (MSNs) express less preprodynorphin (PPD), prep...

journal_title：Brain structure & function

authors： Saylor AJ,McGinty JF

更新日期：2010-08-01 00:00:00

abstract：:The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular f...

journal_title：Brain structure & function

authors： Cahill LS,Bishop J,Gazdzinski LM,Dorr A,Stefanovic B,Sled JG

更新日期：2017-11-01 00:00:00

abstract：:Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-base...

journal_title：Brain structure & function

authors： Takeuchi H,Taki Y,Nouchi R,Sekiguchi A,Kotozaki Y,Miyauchi CM,Yokoyama R,Iizuka K,Hashizume H,Nakagawa S,Kunitoki K,Sassa Y,Kawashima R

更新日期：2014-01-01 00:00:00

abstract：:Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...

journal_title：Brain structure & function

authors： Kong V,Devenyi GA,Gallino D,Ayranci G,Germann J,Rollins C,Chakravarty MM

更新日期：2018-09-01 00:00:00

abstract：:Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhi...

journal_title：Brain structure & function

authors： Roberts BM,White MG,Patton MH,Chen R,Mathur BN

更新日期：2019-09-01 00:00:00

abstract：:Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employe...

journal_title：Brain structure & function

authors： Rhindress K,Ikuta T,Wellington R,Malhotra AK,Szeszko PR

更新日期：2015-11-01 00:00:00

abstract：:Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...

journal_title：Brain structure & function

authors： Palande NV,Biswas S,Jadhao AG

更新日期：2011-03-01 00:00:00

abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...

journal_title：Brain structure & function

authors： Greathouse KM,Boros BD,Deslauriers JF,Henderson BW,Curtis KA,Gentry EG,Herskowitz JH

更新日期：2018-12-01 00:00:00

abstract：:The cerebellum receives sensory signals from spinocerebellar (lower limbs) and dorsal column nuclei (upper limbs) mossy fibers. In the cerebellum, mossy fibers terminate in bands that are topographically aligned with stripes of Purkinje cells. While much is known about the molecular heterogeneity of Purkinje cell stri...

journal_title：Brain structure & function

authors： Gebre SA,Reeber SL,Sillitoe RV

更新日期：2012-04-01 00:00:00

abstract：:The rostral nucleus of the solitary tract (rNST) receives gustatory input via chorda tympani (CT) afferents from the anterior two-thirds of the tongue and transmits it to higher brain regions. To help understand how the gustatory information is processed at the 1st relay nucleus of the brain stem, we investigated the ...

journal_title：Brain structure & function

authors： Park SK,Lee DS,Bae JY,Bae YC

更新日期：2016-03-01 00:00:00

abstract：:Neuronatomical and pharmacological studies have established GABA-mediated inhibition of the HPA axis at the level of the PVN. The origin of this innervation is a series of local hypothalamic and adjacent forebrain regions that project to stress-integrative hypophysiotropic CRH neurons. While a role in tonic inhibition...

journal_title：Brain structure & function

authors： Cullinan WE,Ziegler DR,Herman JP

更新日期：2008-09-01 00:00:00

abstract：:The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. To...

journal_title：Brain structure & function

authors： Rogers Flattery CN,Rosen RF,Farberg AS,Dooyema JM,Hof PR,Sherwood CC,Walker LC,Preuss TM

更新日期：2020-11-01 00:00:00