The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.

abstract：:Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....

journal_title：Brain structure & function

authors： Tripathi A,Schenker E,Spedding M,Jay TM

更新日期：2016-05-01 00:00:00

abstract：:Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem...

journal_title：Brain structure & function

authors： Ruehl RM,Hinkel C,Bauermann T,Eulenburg PZ

更新日期：2017-12-01 00:00:00

abstract：:Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...

journal_title：Brain structure & function

authors： Palande NV,Biswas S,Jadhao AG

更新日期：2011-03-01 00:00:00

abstract：:Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...

journal_title：Brain structure & function

authors： Uesaki M,Takemura H,Ashida H

更新日期：2018-01-01 00:00:00

abstract：:Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...

journal_title：Brain structure & function

authors： Ugwu ID,Amico F,Carballedo A,Fagan AJ,Frodl T

更新日期：2015-07-01 00:00:00

abstract：:Higher cognitive processes and emotional regulation depend on densely interconnected telencephalic and limbic areas. Central structures of this cortico-limbic network are ventral hippocampus (vHC), medial prefrontal cortex (PFC), basolateral amygdala (BLA) and nucleus accumbens (NAC). Human and animal studies have rev...

journal_title：Brain structure & function

authors： Khastkhodaei Z,Muthuraman M,Yang JW,Groppa S,Luhmann HJ

更新日期：2021-01-13 00:00:00

abstract：:Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chr...

journal_title：Brain structure & function

authors： Pinto V,Costa JC,Morgado P,Mota C,Miranda A,Bravo FV,Oliveira TG,Cerqueira JJ,Sousa N

更新日期：2015-03-01 00:00:00

abstract：:Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...

journal_title：Brain structure & function

authors： Muly EC,Senyuz M,Khan ZU,Guo JD,Hazra R,Rainnie DG

更新日期：2009-09-01 00:00:00

abstract：:One of the major challenges of functional magnetic resonance imaging (fMRI) data analysis is to develop simple and reliable methods to correlate brain regions with functionality. In this paper, we employ a detrending-based fractal method, called detrended fluctuation analysis (DFA), to identify brain activity from fMR...

journal_title：Brain structure & function

authors： Hu J,Lee JM,Gao J,White KD,Crosson B

更新日期：2008-02-01 00:00:00

abstract：:The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...

journal_title：Brain structure & function

authors： Svobodová Burianová J,Syka J

更新日期：2020-09-01 00:00:00

abstract：:The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...

journal_title：Brain structure & function

authors： Ovsepian SV

更新日期：2019-04-01 00:00:00

abstract：:The fornix is the primary efferent pathway of the hippocampus and plays a central role in memory circuitry. Diffusion tensor imaging has shown changes in the fornix with typical development and aging. Here, the fornix was investigated in 903 healthy young adult participants aged 22-36 years old from the high-spatial r...

journal_title：Brain structure & function

authors： Cahn AJ,Little G,Beaulieu C,Tétreault P

更新日期：2021-01-02 00:00:00

abstract：:Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using ...

journal_title：Brain structure & function

authors： Takahashi H,Brasnjevic I,Rutten BP,Van Der Kolk N,Perl DP,Bouras C,Steinbusch HW,Schmitz C,Hof PR,Dickstein DL

更新日期：2010-03-01 00:00:00

abstract：:Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....

journal_title：Brain structure & function

authors： Hutlet B,Theys N,Coste C,Ahn MT,Doshishti-Agolli K,Lizen B,Gofflot F

更新日期：2016-04-01 00:00:00

abstract：:Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...

journal_title：Brain structure & function

authors： Hildebrandt S,Schmidt A,Stoll A,Schmitt O,Köhling R,Wree A,Haas SJ,Pützer BM

更新日期：2010-08-01 00:00:00

abstract：:The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research wa...

journal_title：Brain structure & function

authors： Jednoróg K,Gawron N,Marchewka A,Heim S,Grabowska A

更新日期：2014-09-01 00:00:00

abstract：:Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult ...

journal_title：Brain structure & function

authors： Faralli A,Dagna F,Albera A,Bekku Y,Oohashi T,Albera R,Rossi F,Carulli D

更新日期：2016-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...

journal_title：Brain structure & function

authors： Chen K,Northington FJ,Martin LJ

更新日期：2010-03-01 00:00:00

abstract：:Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...

journal_title：Brain structure & function

authors： Ramos-Moreno T,Clascá F

更新日期：2014-09-01 00:00:00

abstract：:Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...

journal_title：Brain structure & function

authors： Uemura Y,Haque T,Sato F,Tsutsumi Y,Ohara H,Oka A,Furuta T,Bae YC,Yamashiro T,Tachibana Y,Yoshida A

更新日期：2020-09-01 00:00:00

abstract：:We are often faced with situations requiring the execution of a coordinated cascade of different actions to achieve a goal, but we can apply different strategies to do so. Until now, these different action cascading strategies have, however, not been examined with respect to possible effects of aging. We tackled this ...

journal_title：Brain structure & function

authors： Stock AK,Gohil K,Beste C

更新日期：2016-06-01 00:00:00

abstract：:The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...

journal_title：Brain structure & function

authors： Felix RA 2nd,Magnusson AK,Berrebi AS

更新日期：2015-09-01 00:00:00

abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...

journal_title：Brain structure & function

authors： Dieni CV,Ferraresi A,Sullivan JA,Grassi S,Pettorossi VE,Panichi R

更新日期：2018-03-01 00:00:00

abstract：:During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalam...

journal_title：Brain structure & function

authors： Murcia-Ramón R,Company V,Juárez-Leal I,Andreu-Cervera A,Almagro-García F,Martínez S,Echevarría D,Puelles E

更新日期：2020-12-01 00:00:00

abstract：:The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, by systemic or local administration to the pedunculopontine nucleus, can both influence sleep. We previously demonstra...

journal_title：Brain structure & function

authors： Kovács A,Bordás C,Bíró T,Hegyi Z,Antal M,Szücs P,Pál B

更新日期：2017-01-01 00:00:00

abstract：:The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...

journal_title：Brain structure & function

authors： Martinez-Gonzalez C,van Andel J,Bolam JP,Mena-Segovia J

更新日期：2014-07-01 00:00:00

abstract：:The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...

journal_title：Brain structure & function

authors： Zhang CL,Houbaert X,Lepleux M,Deshors M,Normand E,Gambino F,Herzog E,Humeau Y

更新日期：2015-11-01 00:00:00

abstract：:To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...

journal_title：Brain structure & function

authors： Demertzi A,Van Ombergen A,Tomilovskaya E,Jeurissen B,Pechenkova E,Di Perri C,Litvinova L,Amico E,Rumshiskaya A,Rukavishnikov I,Sijbers J,Sinitsyn V,Kozlovskaya IB,Sunaert S,Parizel PM,Van de Heyning PH,Laureys S,Wuyts F

更新日期：2016-06-01 00:00:00

abstract：:The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

journal_title：Brain structure & function

authors： Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

更新日期：2014-03-01 00:00:00

abstract：:Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

journal_title：Brain structure & function

authors： Kellermann T,Scholle R,Schneider F,Habel U

更新日期：2017-03-01 00:00:00