Abstract：
:Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders. Our results, establish the existence of a topographical, monosynaptic pathway originating exclusively from the ventral CA1 and subiculum to the mPFC. Functional connectivity of the H-PFC pathway, examined in vivo through field potential recordings in the prelimbic mPFC after high-frequency stimulation of the hippocampal outflow, demonstrates an induction of a significant long lasting long-term potentiation, which is stable for at least one hour and strongly impaired by exposure to acute stress. Given that stress exposure is known to have serious detrimental effects on prefrontal cortical functioning and is considered a major risk factor for several neuropsychiatric disorders, the present study provides a crucial animal model of neural interaction and response to environmental stress which could lend itself to the study of disruption of brain circuits and test for potential drug candidates.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Tripathi A,Schenker E,Spedding M,Jay TMdoi
10.1007/s00429-015-1023-xsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
2385-91issue
4eissn
1863-2653issn
1863-2661pii
10.1007/s00429-015-1023-xjournal_volume
221pub_type
杂志文章abstract：:Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatment, we examined neocortical cell numbers, volume, surface area and thi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01881-1
更新日期：2019-06-01 00:00:00
abstract：:The telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major domains: striatum, pallidum, diagonal area and preoptic area (Puelles et al. 2013; Allen Developin...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1086-8
更新日期：2016-07-01 00:00:00
abstract：:Glucose metabolism produces, by oxidative phosphorylation, more than 15 times the amount of energy generated by aerobic glycolysis. Nonetheless, aerobic glycolysis remains a prevalent metabolic pathway in the brain. Here we review evidence suggesting that this pathway contributes essential molecules to the biomass of ...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-013-0662-z
更新日期：2014-07-01 00:00:00
abstract：:Rapid behavioral responses to unexpected events in the acoustic environment are critical for survival. Stimulus-specific adaptation (SSA) is the process whereby some auditory neurons respond better to rare stimuli than to repetitive stimuli. Most experiments on SSA have been performed under anesthesia, and it is unkno...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0862-1
更新日期：2015-11-01 00:00:00
abstract：:Projections from the prefrontal cortex (PFC) to the amygdala (AMG) regulate affective behaviors in a manner that is modulated by dopamine (DA). Although PFC and DA inputs overlap within the basolateral nucleus (BLA) and intercalated cell masses (ICMs), the spatial relationship between these afferents has not been inve...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0180-6
更新日期：2008-09-01 00:00:00
abstract：:The characterization of neuronal properties is a necessary first step toward understanding how the ventrolateral preoptic nucleus (VLPO) neuronal network regulates slow-wave sleep (SWS). Indeed, the electrophysiological heterogeneity of VLPO neurons suggests the existence of subtypes that could differently contribute ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1265-2
更新日期：2017-04-01 00:00:00
abstract：:The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders....
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0572-0
更新日期：2014-07-01 00:00:00
abstract：:Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward cu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1559-z
更新日期：2018-04-01 00:00:00
abstract：:Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0591-x
更新日期：2014-09-01 00:00:00
abstract：:Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0694-4
更新日期：2015-03-01 00:00:00
abstract：:Diffusion tensor imaging (DTI) has become a valuable tool to investigate white matter integrity in the brain. DTI also gives contrast in gray matter, which has been relatively little explored in studies assessing post-injury structural abnormalities. The present study was designed to compare white and gray matter reor...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0683-7
更新日期：2015-03-01 00:00:00
abstract：:Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01872-2
更新日期：2019-06-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0769-x
更新日期：2015-07-01 00:00:00
abstract：:The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1000-4
更新日期：2016-04-01 00:00:00
abstract：:Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0218-4
更新日期：2009-10-01 00:00:00
abstract：:Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1431-1
更新日期：2017-11-01 00:00:00
abstract：:The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adop...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0355-4
更新日期：2012-04-01 00:00:00
abstract：:The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0579-6
更新日期：2014-07-01 00:00:00
abstract：:The frontal cortico-basal ganglia network plays a central role in action selection, associative learning, and motivation, processes requiring the integration of information from functionally distinct cortical regions. The cortico-striatal projection is a likely substrate of information integration, as terminal fields ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1662-9
更新日期：2018-07-01 00:00:00
abstract：:The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN). Functionally, NUCB2/nesfatin-1 neurons in the PVN regulate feeding through the hypothalamus and brain st...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1150-4
更新日期：2016-12-01 00:00:00
abstract：:Retinoic acid, the active form of the nutrient vitamin A, regulates several facets of neuronal plasticity in the hippocampus, including neurogenesis and synaptic strength, acting via specific retinoic acid receptors (RARs). Essential for conversion of vitamin A to retinoic acid is the enzyme retinaldehyde dehydrogenas...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0359-0
更新日期：2012-04-01 00:00:00
abstract：:Recently, neuroimaging-based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis has attracted researchers in the field, due to the increasing prevalence of the diseases. Unfortunately, the unfavorable high-dimensional nature of neuroimaging data, but a limited small number of samples available, make...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1059-y
更新日期：2016-06-01 00:00:00
abstract：:Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0781-1
更新日期：2015-07-01 00:00:00
abstract：:Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1142-4
更新日期：2016-11-01 00:00:00
abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1748-4
更新日期：2018-12-01 00:00:00
abstract：:Cerebellar volume declines with aging. Few studies have investigated age differences in regional cerebellar volume (RCV) and their association with motor and cognitive function. In 213 healthy older adults, we investigated the association of age with motor skills, cognition and RCV. Subsequently, we studied the associ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1317-7
更新日期：2017-05-01 00:00:00
abstract：:The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-019-01835-7
更新日期：2019-04-01 00:00:00
abstract：:The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitive...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0700-x
更新日期：2015-03-01 00:00:00
abstract：:The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1716-z
更新日期：2018-11-01 00:00:00
abstract：:The Ly-6 superfamily of proteins, which affects diverse processes in the immune system, has attracted renewed attention due to the ability of some Ly-6 proteins to bind to and modulate the function of neuronal nicotinic acetylcholine receptors (nAChRs). However, there is a scarcity of knowledge regarding the distribut...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0611-x
更新日期：2014-11-01 00:00:00
