Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study.

Abstract:

:Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in individuals with major depressive disorder (MDD) and healthy controls (HC). DTI was obtained from 46 subjects with MDD and 46 HC subjects. Data were pre-processed and deterministic tractography was applied in the cingulum, uncinate fasciculus (UF), fornix, superior longitudinal fasciculus (SLF) and fronto-occipital fasciculus (FOF). In subjects with a history of CA, fractional anisotropy (FA) was greater in the rostral cingulum (RC) and dorsal cingulum, whereas radial diffusivity (RD) was smaller in the RC when compared with subjects with no history of CA. In the UF, FOF and parahippocampal cingulum, FA was greater in the left hemisphere in the subjects with CA when compared with those without CA. Age affected FA, longitudinal diffusivity and RD in the UF, fornix, FOF and SLF, reflecting axonal and myelin degeneration with increasing age. Depression or gender did not have any effects on the diffusivity measures. Due to the cross-sectional nature of the study, a recall bias for CA and possible effects of medical treatment on diffusivity measures could have played a role. CA and age could increase the likelihood to develop WM microstructural anomalies in the brain affective network. Moreover, subjects with CA could be more vulnerable to FA changes.

journal_name

Brain Struct Funct

authors

Ugwu ID,Amico F,Carballedo A,Fagan AJ,Frodl T

doi

10.1007/s00429-014-0769-x

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

1997-2009

issue

4

eissn

1863-2653

issn

1863-2661

journal_volume

220

pub_type

杂志文章
  • Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.

    abstract::Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understoo...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1142-4

    authors: Fernandez SP,Cauli B,Cabezas C,Muzerelle A,Poncer JC,Gaspar P

    更新日期:2016-11-01 00:00:00

  • Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism.

    abstract::Although type 1 cannabinoid receptors (CB1Rs) are expressed abundantly throughout the brain, the presence of type 2 cannabinoid receptors (CB2Rs) in neurons is still somewhat controversial. Taking advantage of newly designed CB1R and CB2R mRNA riboprobes, we demonstrate by PCR and in situ hybridization that transcript...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0823-8

    authors: Sierra S,Luquin N,Rico AJ,Gómez-Bautista V,Roda E,Dopeso-Reyes IG,Vázquez A,Martínez-Pinilla E,Labandeira-García JL,Franco R,Lanciego JL

    更新日期:2015-09-01 00:00:00

  • Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.

    abstract::The amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field extern...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02201-8

    authors: Garcia-Calero E,Puelles L

    更新日期:2021-01-30 00:00:00

  • Computational neuroanatomy of human stratum proprium of interparietal sulcus.

    abstract::Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1492-1

    authors: Uesaki M,Takemura H,Ashida H

    更新日期:2018-01-01 00:00:00

  • mGluR4-containing corticostriatal terminals: synaptic interactions with direct and indirect pathway neurons in mice.

    abstract::Glutamatergic afferents from the cerebral cortex are the main excitatory drive of striatal projection neurons. The metabotropic glutamate receptor 4 (mGluR4) presynaptically modulates transmission at corticostriatal synapses, and is considered as a potent drug target for Parkinson's disease and other brain disorders. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1187-z

    authors: Iskhakova L,Smith Y

    更新日期:2016-12-01 00:00:00

  • Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.

    abstract::The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1385-3

    authors: Bellier JP,Xie Y,Farouk SM,Sakaue Y,Tooyama I,Kimura H

    更新日期:2017-09-01 00:00:00

  • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0226-4

    authors: Chen K,Northington FJ,Martin LJ

    更新日期:2010-03-01 00:00:00

  • Study of pallial neurogenesis in shark embryos and the evolutionary origin of the subventricular zone.

    abstract::The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1705-2

    authors: Docampo-Seara A,Lagadec R,Mazan S,Rodríguez MA,Quintana-Urzainqui I,Candal E

    更新日期:2018-11-01 00:00:00

  • Frontotemporal correlates of impulsivity and machine learning in retired professional athletes with a history of multiple concussions.

    abstract::The frontotemporal cortical network is associated with behaviours such as impulsivity and aggression. The health of the uncinate fasciculus (UF) that connects the orbitofrontal cortex (OFC) with the anterior temporal lobe (ATL) may be a crucial determinant of behavioural regulation. Behavioural changes can emerge afte...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1012-0

    authors: Goswami R,Dufort P,Tartaglia MC,Green RE,Crawley A,Tator CH,Wennberg R,Mikulis DJ,Keightley M,Davis KD

    更新日期:2016-05-01 00:00:00

  • Superior olivary complex organization and cytoarchitecture may be correlated with function and catarrhine primate phylogeny.

    abstract::In the mammalian auditory system, the medial nucleus of the trapezoid body and the lateral superior olive (MNTB-LSO system) contribute to binaural intensity processing and lateralization. Localization precision varies with the sound frequencies. As recency of common ancestry with human beings increases, primates have ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-008-0201-5

    authors: Hilbig H,Beil B,Hilbig H,Call J,Bidmon HJ

    更新日期:2009-09-01 00:00:00

  • Cortical reorganization in an astronaut's brain after long-duration spaceflight.

    abstract::To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1054-3

    authors: Demertzi A,Van Ombergen A,Tomilovskaya E,Jeurissen B,Pechenkova E,Di Perri C,Litvinova L,Amico E,Rumshiskaya A,Rukavishnikov I,Sijbers J,Sinitsyn V,Kozlovskaya IB,Sunaert S,Parizel PM,Van de Heyning PH,Laureys S,Wuyts F

    更新日期:2016-06-01 00:00:00

  • Absolute and relative pitch processing in the human brain: neural and behavioral evidence.

    abstract::Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01872-2

    authors: Leipold S,Brauchli C,Greber M,Jäncke L

    更新日期:2019-06-01 00:00:00

  • In vivo assembly of the axon initial segment in motor neurons.

    abstract::The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the A...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0578-7

    authors: Le Bras B,Fréal A,Czarnecki A,Legendre P,Bullier E,Komada M,Brophy PJ,Davenne M,Couraud F

    更新日期:2014-07-01 00:00:00

  • Identification of CNS neurons with polysynaptic connections to both the sympathetic and parasympathetic innervation of the submandibular gland.

    abstract::Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0781-1

    authors: Hettigoda NS,Fong AY,Badoer E,McKinley MJ,Oldfield BJ,Allen AM

    更新日期:2015-07-01 00:00:00

  • High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps.

    abstract::The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01919-4

    authors: Huck J,Wanner Y,Fan AP,Jäger AT,Grahl S,Schneider U,Villringer A,Steele CJ,Tardif CL,Bazin PL,Gauthier CJ

    更新日期:2019-09-01 00:00:00

  • Systematic expression analysis of Hox genes at adulthood reveals novel patterns in the central nervous system.

    abstract::Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0965-8

    authors: Hutlet B,Theys N,Coste C,Ahn MT,Doshishti-Agolli K,Lizen B,Gofflot F

    更新日期:2016-04-01 00:00:00

  • Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.

    abstract::Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1691-4

    authors: Kong V,Devenyi GA,Gallino D,Ayranci G,Germann J,Rollins C,Chakravarty MM

    更新日期:2018-09-01 00:00:00

  • Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress.

    abstract::Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1720-3

    authors: Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

    更新日期:2018-11-01 00:00:00

  • The visual white matter connecting human area prostriata and the thalamus is retinotopically organized.

    abstract::The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preferenc...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02096-5

    authors: Kurzawski JW,Mikellidou K,Morrone MC,Pestilli F

    更新日期:2020-07-01 00:00:00

  • Enhanced representation of natural sound sequences in the ventral auditory midbrain.

    abstract::The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02188-2

    authors: González-Palomares E,López-Jury L,García-Rosales F,Hechavarria JC

    更新日期:2021-01-01 00:00:00

  • Orexin-dependent activation of layer VIb enhances cortical network activity and integration of non-specific thalamocortical inputs.

    abstract::Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wa...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0869-7

    authors: Hay YA,Andjelic S,Badr S,Lambolez B

    更新日期:2015-11-01 00:00:00

  • Tuning the brain for motherhood: prolactin-like central signalling in virgin, pregnant, and lactating female mice.

    abstract::Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1254-5

    authors: Salais-López H,Lanuza E,Agustín-Pavón C,Martínez-García F

    更新日期:2017-03-01 00:00:00

  • Anatomical predictors of cognitive decline after subthalamic stimulation in Parkinson's disease.

    abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1677-2

    authors: Planche V,Munsch F,Pereira B,de Schlichting E,Vidal T,Coste J,Morand D,de Chazeron I,Derost P,Debilly B,Llorca PM,Lemaire JJ,Marques A,Durif F

    更新日期:2018-09-01 00:00:00

  • Realistic modelling of receptor activation in hippocampal excitatory synapses: analysis of multivesicular release, release location, temperature and synaptic cross-talk.

    abstract::Chemically mediated synaptic transmission results from fusion of synaptic vesicles with the presynaptic plasma membrane, subsequent release of the vesicular content into the cleft and binding to postsynaptic receptors. Previous modelling studies of excitatory neurotransmitter glutamate were based on simplified geometr...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0273-x

    authors: Boucher J,Kröger H,Sík A

    更新日期:2010-07-01 00:00:00

  • Dopaminergic innervation of pyramidal cells in the rat basolateral amygdala.

    abstract::Dopaminergic (DA) inputs to the basolateral nuclear complex of the amygdala (BLC) are critical for several important functions, including reward-related learning, drug-stimulus learning, and fear conditioning. Despite the importance of the DA projection to the BLC, very little is known about which neuronal subpopulati...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-008-0196-y

    authors: Muller JF,Mascagni F,McDonald AJ

    更新日期:2009-02-01 00:00:00

  • The connectome of the basal ganglia.

    abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...

    journal_title:Brain structure & function

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00429-014-0936-0

    authors: Schmitt O,Eipert P,Kettlitz R,Leßmann F,Wree A

    更新日期:2016-03-01 00:00:00

  • Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation.

    abstract::Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and agoraphobia in a contextual fear conditioning paradigm. In this study, we further analysed our previous data ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02102-w

    authors: Tan SZK,Temel Y,Chan AY,Mok ATC,Perucho JAU,Blokland A,Aquili L,Lim WL,Lim LW

    更新日期:2020-09-01 00:00:00

  • Parasagittal compartmentation of cerebellar mossy fibers as revealed by the patterned expression of vesicular glutamate transporters VGLUT1 and VGLUT2.

    abstract::The cerebellum receives sensory signals from spinocerebellar (lower limbs) and dorsal column nuclei (upper limbs) mossy fibers. In the cerebellum, mossy fibers terminate in bands that are topographically aligned with stripes of Purkinje cells. While much is known about the molecular heterogeneity of Purkinje cell stri...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0339-4

    authors: Gebre SA,Reeber SL,Sillitoe RV

    更新日期:2012-04-01 00:00:00

  • The dark matter of the brain.

    abstract::The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action pot...

    journal_title:Brain structure & function

    pub_type: 杂志文章,评审

    doi:10.1007/s00429-019-01835-7

    authors: Ovsepian SV

    更新日期:2019-04-01 00:00:00

  • Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity.

    abstract::Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0778-9

    authors: Nordenankar K,Smith-Anttila CJ,Schweizer N,Viereckel T,Birgner C,Mejia-Toiber J,Morales M,Leao RN,Wallén-Mackenzie Å

    更新日期:2015-07-01 00:00:00