Abstract：
:The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the AIS master organizer, is undetectable in bipolar migrating motor neurons, but is already expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. Then, from E11.5, a stage when AnkG is already apposed to the membrane, as observed by electron microscopy, the protein progressively becomes restricted to the proximal axon. Analysis on the global motor neurons population indicated that Neurofascin follows an identical spatio-temporal distribution, whereas sodium channels and β4-spectrin only appear along AnkG(+) segments at E11.5. Early patch-clamp recordings of individual motor neurons indicated that at E12.5 these nascent AISs are already able to generate spikes. Using knock-out mice, we demonstrated that neither β4-spectrin nor Neurofascin control the distal-to-proximal restriction of AnkG.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Le Bras B,Fréal A,Czarnecki A,Legendre P,Bullier E,Komada M,Brophy PJ,Davenne M,Couraud Fdoi
10.1007/s00429-013-0578-7subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1433-50issue
4eissn
1863-2653issn
1863-2661journal_volume
219pub_type
杂志文章abstract：:The baboon provides a model of photosensitive, generalized epilepsy. This study compares cerebral blood flow responses during intermittent light stimulation (ILS) between photosensitive (PS) and healthy control (CTL) baboons using H 2 (15) O-PET. We examined effective connectivity associated with visual stimulation in...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1022-y
更新日期：2016-05-01 00:00:00
abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1514-z
更新日期：2018-03-01 00:00:00
abstract：:Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0218-4
更新日期：2009-10-01 00:00:00
abstract：:The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0988-1
更新日期：2016-04-01 00:00:00
abstract：:Previous work in the precocious rodent Octodon degus has shown that exposure to early life stress (ELS) (induced by repeated parental separation) results in changes of excitatory, inhibitory and modulatory transmitter systems in prefrontal and limbic regions of the male brain. The aim of this study was to test the hyp...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0688-2
更新日期：2015-03-01 00:00:00
abstract：:Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. T...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0382-9
更新日期：2013-01-01 00:00:00
abstract：:Neuronal replacement in the pallial song control nucleus HVC of adult zebra finches constitutes an interesting case of homeostatic plasticity; in spite of continuous addition and attrition of neurons in ensembles that code song elements, adult song remains remarkably invariant. New neurons migrate into HVC and later s...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1006-y
更新日期：2016-05-01 00:00:00
abstract：:The anatomic gene expression atlas (AGEA) of the adult mouse brain of the Allen Institute for Brain Science is a transcriptome-based atlas of the adult C57Bl/6 J mouse brain, based on the extensive in situ hybridization dataset of the Institute. This spatial mapping of the gene expression levels of mice under baseline...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02108-4
更新日期：2020-09-01 00:00:00
abstract：:The rostral nucleus of the solitary tract (rNST) receives gustatory input via chorda tympani (CT) afferents from the anterior two-thirds of the tongue and transmits it to higher brain regions. To help understand how the gustatory information is processed at the 1st relay nucleus of the brain stem, we investigated the ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0959-6
更新日期：2016-03-01 00:00:00
abstract：:In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information. Here we studied the visual and somatosensory properties of the areas PEc and V6Ad located in between the somatosensory and visual...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1593-x
更新日期：2018-05-01 00:00:00
abstract：:Distribution of bromodeoxyuridine immunoreactive (BrdU-IR) cell nuclei was analyzed at proximal and remote cortical sites in adult Cebus apella monkeys after a programmed surgical lesion placed either in the prefrontal or in the striate cerebral cortex. Increased GFAP-IR and vimentin-IR astrocytes, as well as Isolecti...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0356-3
更新日期：2012-04-01 00:00:00
abstract：:Brain pathology in Friedreich ataxia is characterized by progressive degeneration of nervous tissue in the brainstem, cerebellum and cerebellar peduncles. Evidence of cerebral involvement is however equivocal. This brain imaging study investigates cerebello-cerebral white matter connectivity in Friedreich ataxia with ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0547-1
更新日期：2014-05-01 00:00:00
abstract：:Retinoic acid, the active form of the nutrient vitamin A, regulates several facets of neuronal plasticity in the hippocampus, including neurogenesis and synaptic strength, acting via specific retinoic acid receptors (RARs). Essential for conversion of vitamin A to retinoic acid is the enzyme retinaldehyde dehydrogenas...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0359-0
更新日期：2012-04-01 00:00:00
abstract：:World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1322-x
更新日期：2017-07-01 00:00:00
abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1748-4
更新日期：2018-12-01 00:00:00
abstract：:The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial deb...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0809-6
更新日期：2015-09-01 00:00:00
abstract：:Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1769-z
更新日期：2019-01-01 00:00:00
abstract：:AMIGO2, or amphoterin-induced gene and ORF (open reading frame) 2, belongs to the leucine-rich repeats and immunoglobulin superfamilies. The protein is a downstream target of calcium-dependent survival signals and, therefore, promotes neuronal survival. Here, we describe the mRNA distribution pattern of AMIGO2 through...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0387-4
更新日期：2013-01-01 00:00:00
abstract：:Agenesis of the corpus callosum (AgCC) is a congenital condition associated with wide-ranging emotional and social impairments often overlapping with the diagnostic criteria for autism. Mapping functional connectivity in the acallosal brain can help identify neural correlates of the deficits associated with this condi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0948-9
更新日期：2016-03-01 00:00:00
abstract：:Early-life sleep deprivation (ESD) is a serious condition with severe metabolic sequelae. The pineal hormone melatonin plays an important role in homeostatic regulation of metabolic function. Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstrea...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0716-x
更新日期：2015-03-01 00:00:00
abstract：:Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chr...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0713-0
更新日期：2015-03-01 00:00:00
abstract：:To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02047-0
更新日期：2020-05-01 00:00:00
abstract：:The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adop...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0355-4
更新日期：2012-04-01 00:00:00
abstract：:The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0560-4
更新日期：2014-07-01 00:00:00
abstract：:The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0882-x
更新日期：2015-11-01 00:00:00
abstract：:The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1705-2
更新日期：2018-11-01 00:00:00
abstract：:Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1590-0
更新日期：2018-05-01 00:00:00
abstract：:Dopaminergic (DA) inputs to the basolateral nuclear complex of the amygdala (BLC) are critical for several important functions, including reward-related learning, drug-stimulus learning, and fear conditioning. Despite the importance of the DA projection to the BLC, very little is known about which neuronal subpopulati...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0196-y
更新日期：2009-02-01 00:00:00
abstract：:The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0530-x
更新日期：2014-03-01 00:00:00
abstract：:Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1750-x
更新日期：2018-12-01 00:00:00
