Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation.


:The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adopted the postweaning social isolation paradigm to model neuropsychiatric disorders and studied the functional and structural changes of the mesocorticolimbic system. After 8-9 weeks of isolation, rats exhibited hyperlocomotor activity and impaired sensorimotor gating compared to group-reared controls. However, the number of tyrosine hydroxylase-positive VTA neurons and the volume of VTA were not affected. Comparing with group-reared controls, the DA levels in the isolation-reared were not altered in the VTA, mPFC and NAc but decreased in the AMY. In the structural aspect, dendritic features of layer II/III pyramidal mPFC neurons; pyramidal neurons in the basolateral nucleus of amygdala (BLA) and medium spiny neurons in the core region of the NAc (NAcc) were examined. Interestingly, the neuronal changes were region-specific. The mPFC neurons had reduced dendritic complexity, spine density and elongated terminal branches. The BLA neurons had extensive dendritic arbors with short branches but unchanged spine density. The NAcc neurons had reduced total dendritic length but the segment length and spine density remained the same. Together, the results demonstrated the structural and functional changes in the mesocorticolimbic DA system of socially isolated rats. These changes may account for the behavioral impairments in these rats and attribute to the susceptibility to mental disorders related to schizophrenia and depression.


Brain Struct Funct


Wang YC,Ho UC,Ko MC,Liao CC,Lee LJ




Has Abstract


2012-04-01 00:00:00












  • Rapid immunostaining method for three-dimensional volume imaging of biological tissues by magnetic force-induced focusing of the electric field.

    abstract::Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Na M,Kim K,Lim HR,Ha CM,Chang S

    更新日期:2021-01-01 00:00:00

  • Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors.

    abstract::Projections from the prefrontal cortex (PFC) to the amygdala (AMG) regulate affective behaviors in a manner that is modulated by dopamine (DA). Although PFC and DA inputs overlap within the basolateral nucleus (BLA) and intercalated cell masses (ICMs), the spatial relationship between these afferents has not been inve...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Pinto A,Sesack SR

    更新日期:2008-09-01 00:00:00

  • Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.

    abstract::Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adu...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Chen NK,Chou YH,Song AW,Madden DJ

    更新日期:2009-10-01 00:00:00

  • Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome.

    abstract::Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer's disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in learning, attention and memory, as well as atrophy of basal forebrain c...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Powers BE,Velazquez R,Kelley CM,Ash JA,Strawderman MS,Alldred MJ,Ginsberg SD,Mufson EJ,Strupp BJ

    更新日期:2016-12-01 00:00:00

  • Use of computational fluid dynamics for 3D fiber tract visualization on human high-thickness histological slices: histological mesh tractography.

    abstract::Understanding the intricate three-dimensional relationship between fiber bundles and subcortical nuclei is not a simple task. It is of paramount importance in neurosciences, especially in the field of functional neurosurgery. The current methods for in vivo and post mortem fiber tract visualization have shortcomings a...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Alho EJL,Fonoff ET,Di Lorenzo Alho AT,Nagy J,Heinsen H

    更新日期:2021-01-03 00:00:00

  • Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections.

    abstract::Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Radtke-Schuller S,Town SM,Yin P,Elgueda D,Schuller G,Bizley JK,Shamma SA,Fritz JB

    更新日期:2020-06-01 00:00:00

  • Blood total antioxidant status is associated with cortical glucose uptake and factors related to accelerated aging.

    abstract::Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total a...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Palomar-Bonet M,Atienza M,Cantero JL

    更新日期:2020-03-01 00:00:00

  • Action selection in a possible model of striatal medium spiny neuron dysfunction: behavioral and EEG data in a patient with benign hereditary chorea.

    abstract::Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but ...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Beste C,Saft C

    更新日期:2015-01-01 00:00:00

  • Projections from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding.

    abstract::The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN). Functionally, NUCB2/nesfatin-1 neurons in the PVN regulate feeding through the hypothalamus and brain st...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Maejima Y,Kumamoto K,Takenoshita S,Shimomura K

    更新日期:2016-12-01 00:00:00

  • The surface area of early visual cortex predicts the amplitude of the visual evoked potential.

    abstract::The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Elvsåshagen T,Moberget T,Bøen E,Hol PK,Malt UF,Andersson S,Westlye LT

    更新日期:2015-03-01 00:00:00

  • Connectivity-based parcellation of the human frontal polar cortex.

    abstract::The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial deb...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Moayedi M,Salomons TV,Dunlop KA,Downar J,Davis KD

    更新日期:2015-09-01 00:00:00

  • Sensory properties of the caudal aspect of the macaque's superior parietal lobule.

    abstract::In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information. Here we studied the visual and somatosensory properties of the areas PEc and V6Ad located in between the somatosensory and visual...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Gamberini M,Dal Bò G,Breveglieri R,Briganti S,Passarelli L,Fattori P,Galletti C

    更新日期:2018-05-01 00:00:00

  • Cortical reorganization in an astronaut's brain after long-duration spaceflight.

    abstract::To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resti...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Demertzi A,Van Ombergen A,Tomilovskaya E,Jeurissen B,Pechenkova E,Di Perri C,Litvinova L,Amico E,Rumshiskaya A,Rukavishnikov I,Sijbers J,Sinitsyn V,Kozlovskaya IB,Sunaert S,Parizel PM,Van de Heyning PH,Laureys S,Wuyts F

    更新日期:2016-06-01 00:00:00

  • Decreasing predictability of visual motion enhances feed-forward processing in visual cortex when stimuli are behaviorally relevant.

    abstract::Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Kellermann T,Scholle R,Schneider F,Habel U

    更新日期:2017-03-01 00:00:00

  • Anatomical predictors of cognitive decline after subthalamic stimulation in Parkinson's disease.

    abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Planche V,Munsch F,Pereira B,de Schlichting E,Vidal T,Coste J,Morand D,de Chazeron I,Derost P,Debilly B,Llorca PM,Lemaire JJ,Marques A,Durif F

    更新日期:2018-09-01 00:00:00

  • Neural circuits underlying tongue movements for the prey-catching behavior in frog: distribution of primary afferent terminals on motoneurons supplying the tongue.

    abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Kecskes S,Matesz C,Gaál B,Birinyi A

    更新日期:2016-04-01 00:00:00

  • The importance of mammillary body efferents for recency memory: towards a better understanding of diencephalic amnesia.

    abstract::Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Nelson AJD,Vann SD

    更新日期:2017-07-01 00:00:00

  • Stimulus-specific adaptation in the inferior colliculus of the mouse: anesthesia and spontaneous activity effects.

    abstract::Rapid behavioral responses to unexpected events in the acoustic environment are critical for survival. Stimulus-specific adaptation (SSA) is the process whereby some auditory neurons respond better to rare stimuli than to repetitive stimuli. Most experiments on SSA have been performed under anesthesia, and it is unkno...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Duque D,Malmierca MS

    更新日期:2015-11-01 00:00:00

  • Enhanced representation of natural sound sequences in the ventral auditory midbrain.

    abstract::The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: González-Palomares E,López-Jury L,García-Rosales F,Hechavarria JC

    更新日期:2021-01-01 00:00:00

  • The rat orbital and agranular insular prefrontal cortical areas: a cytoarchitectonic and chemoarchitectonic study.

    abstract::Cytoarchitectonic characterization of borders is necessary for stereological studies (e.g., total cell number estimation), in which particular cortical areas have to be defined. In this study, cytoarchitectonic characteristics are described and illustrated for the rat ventral or orbital frontal cortical areas, i.e., t...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Van De Werd HJ,Uylings HB

    更新日期:2008-02-01 00:00:00

  • Delineating function and connectivity of optokinetic hubs in the cerebellum and the brainstem.

    abstract::Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Ruehl RM,Hinkel C,Bauermann T,Eulenburg PZ

    更新日期:2017-12-01 00:00:00

  • Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm.

    abstract::The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Bellier JP,Xie Y,Farouk SM,Sakaue Y,Tooyama I,Kimura H

    更新日期:2017-09-01 00:00:00

  • Topography of the human acoustic radiation as revealed by ex vivo fibers micro-dissection and in vivo diffusion-based tractography.

    abstract::The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Maffei C,Jovicich J,De Benedictis A,Corsini F,Barbareschi M,Chioffi F,Sarubbo S

    更新日期:2018-01-01 00:00:00

  • Latent feature representation with stacked auto-encoder for AD/MCI diagnosis.

    abstract::Recently, there have been great interests for computer-aided diagnosis of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). Unlike the previous methods that considered simple low-level features such as gray matter tissue volumes from MRI, and mean signal intensities from PET, in this p...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Suk HI,Lee SW,Shen D,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2015-03-01 00:00:00

  • TMS of the occipital face area modulates cross-domain identity priming.

    abstract::Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Ambrus GG,Amado C,Krohn L,Kovács G

    更新日期:2019-01-01 00:00:00

  • Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence.

    abstract::The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Li R,Zhang J,Wu X,Wen X,Han B

    更新日期:2020-06-01 00:00:00

  • Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.

    abstract::Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Greathouse KM,Boros BD,Deslauriers JF,Henderson BW,Curtis KA,Gentry EG,Herskowitz JH

    更新日期:2018-12-01 00:00:00

  • Orienting movements in area 9 identified by long-train ICMS.

    abstract::The effect of intracortical microstimulation has been studied in several cortical areas from motor to sensory areas. The frontal pole has received particular attention, and several microstimulation studies have been conducted in the frontal eye field, supplementary eye field, and the premotor ear-eye field, but no mic...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Lanzilotto M,Perciavalle V,Lucchetti C

    更新日期:2015-03-01 00:00:00

  • Track-weighted dynamic functional connectivity (TW-dFC): a new method to study time-resolved functional connectivity.

    abstract::Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Calamante F,Smith RE,Liang X,Zalesky A,Connelly A

    更新日期:2017-11-01 00:00:00

  • Loss of serum response factor in mature neurons in the dentate gyrus alters the morphology of dendritic spines and hippocampus-dependent behavioral tasks.

    abstract::Serum response factor (SRF) is a major transcription factor that regulates the expression of several plasticity-associated genes in the brain. Although the developmental expression of SRF in excitatory neurons is crucial for establishing proper hippocampal circuitry, no substantial evidence of its role in unstimulated...

    journal_title:Brain structure & function

    pub_type: 杂志文章


    authors: Nader K,Krysiak A,Beroun A,Pekala M,Szymanska M,Kuzniewska B,Radwanska K,Kaczmarek L,Kalita K

    更新日期:2019-11-01 00:00:00