Local and remote cellular responses following a surgical lesion in the Cebus apella cerebral cortex.

Abstract:

:Distribution of bromodeoxyuridine immunoreactive (BrdU-IR) cell nuclei was analyzed at proximal and remote cortical sites in adult Cebus apella monkeys after a programmed surgical lesion placed either in the prefrontal or in the striate cerebral cortex. Increased GFAP-IR and vimentin-IR astrocytes, as well as IsolectinB4 labeled microglial cells, were observed both at lesional and perilesional areas. After injury at either location, the BrdU nuclear incorporation spread to supragranular layers in remote cortical areas functionally related to the injured cortex, probably due to involvement of degenerated cortico-cortical association fibers. Double labeling with Ki-67 suggested that remote BrdU-IR nuclei belong to proliferating cells, but the cell type remains to be determined, since these nuclei did not correspond to NeuN, MAP2, GFAP, Vimentin and isolectinB4 labeled cells. This remote effect should be incorporated to current clinical and experimental appraisal of cortical lesions.

journal_name

Brain Struct Funct

authors

Lanosa XA,Yáñez A,Alzugaray S,Colombo JA

doi

10.1007/s00429-011-0356-3

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

485-501

issue

2

eissn

1863-2653

issn

1863-2661

journal_volume

217

pub_type

杂志文章
  • Bottom-up and top-down brain functional connectivity underlying comprehension of everyday visual action.

    abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0160-2

    authors: Hanson SJ,Hanson C,Halchenko Y,Matsuka T,Zaimi A

    更新日期:2007-12-01 00:00:00

  • Distribution of D1 and D5 dopamine receptors in the primate and rat basolateral amygdala.

    abstract::Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0214-8

    authors: Muly EC,Senyuz M,Khan ZU,Guo JD,Hazra R,Rainnie DG

    更新日期:2009-09-01 00:00:00

  • Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.

    abstract::Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adu...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0218-4

    authors: Chen NK,Chou YH,Song AW,Madden DJ

    更新日期:2009-10-01 00:00:00

  • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0226-4

    authors: Chen K,Northington FJ,Martin LJ

    更新日期:2010-03-01 00:00:00

  • Parasagittal compartmentation of cerebellar mossy fibers as revealed by the patterned expression of vesicular glutamate transporters VGLUT1 and VGLUT2.

    abstract::The cerebellum receives sensory signals from spinocerebellar (lower limbs) and dorsal column nuclei (upper limbs) mossy fibers. In the cerebellum, mossy fibers terminate in bands that are topographically aligned with stripes of Purkinje cells. While much is known about the molecular heterogeneity of Purkinje cell stri...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0339-4

    authors: Gebre SA,Reeber SL,Sillitoe RV

    更新日期:2012-04-01 00:00:00

  • How do cortico-striatal projections impact on downstream pallidal circuitry?

    abstract::The frontal cortico-basal ganglia network plays a central role in action selection, associative learning, and motivation, processes requiring the integration of information from functionally distinct cortical regions. The cortico-striatal projection is a likely substrate of information integration, as terminal fields ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1662-9

    authors: Heilbronner SR,Meyer MAA,Choi EY,Haber SN

    更新日期:2018-07-01 00:00:00

  • Loss of serum response factor in mature neurons in the dentate gyrus alters the morphology of dendritic spines and hippocampus-dependent behavioral tasks.

    abstract::Serum response factor (SRF) is a major transcription factor that regulates the expression of several plasticity-associated genes in the brain. Although the developmental expression of SRF in excitatory neurons is crucial for establishing proper hippocampal circuitry, no substantial evidence of its role in unstimulated...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01925-6

    authors: Nader K,Krysiak A,Beroun A,Pekala M,Szymanska M,Kuzniewska B,Radwanska K,Kaczmarek L,Kalita K

    更新日期:2019-11-01 00:00:00

  • Decreasing predictability of visual motion enhances feed-forward processing in visual cortex when stimuli are behaviorally relevant.

    abstract::Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1251-8

    authors: Kellermann T,Scholle R,Schneider F,Habel U

    更新日期:2017-03-01 00:00:00

  • Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study.

    abstract::Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0769-x

    authors: Ugwu ID,Amico F,Carballedo A,Fagan AJ,Frodl T

    更新日期:2015-07-01 00:00:00

  • Thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis.

    abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0921-7

    authors: Lao Y,Wang Y,Shi J,Ceschin R,Nelson MD,Panigrahy A,Leporé N

    更新日期:2016-01-01 00:00:00

  • Neuronal tangential migration from Nkx2.1-positive hypothalamus.

    abstract::During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalam...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02163-x

    authors: Murcia-Ramón R,Company V,Juárez-Leal I,Andreu-Cervera A,Almagro-García F,Martínez S,Echevarría D,Puelles E

    更新日期:2020-12-01 00:00:00

  • Tuning the brain for motherhood: prolactin-like central signalling in virgin, pregnant, and lactating female mice.

    abstract::Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1254-5

    authors: Salais-López H,Lanuza E,Agustín-Pavón C,Martínez-García F

    更新日期:2017-03-01 00:00:00

  • Ensemble encoding of action speed by striatal fast-spiking interneurons.

    abstract::Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01908-7

    authors: Roberts BM,White MG,Patton MH,Chen R,Mathur BN

    更新日期:2019-09-01 00:00:00

  • Intrinsic, stimulus-driven and task-dependent connectivity in human auditory cortex.

    abstract::A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1612-6

    authors: Häkkinen S,Rinne T

    更新日期:2018-06-01 00:00:00

  • Neural circuits underlying tongue movements for the prey-catching behavior in frog: distribution of primary afferent terminals on motoneurons supplying the tongue.

    abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0988-1

    authors: Kecskes S,Matesz C,Gaál B,Birinyi A

    更新日期:2016-04-01 00:00:00

  • Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.

    abstract::It is well established that environmental influences play a key role in sculpting neuronal connectivity in the brain. One example is the olfactory sensory map of topographic axonal connectivity. While intrinsic odorant receptor signaling in olfactory sensory neurons (OSN) determines anterior-posterior counter gradient...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0783-z

    authors: Login H,Butowt R,Bohm S

    更新日期:2015-07-01 00:00:00

  • Mapping the intersection of language and reading: the neural bases of the primary systems hypothesis.

    abstract::The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1716-z

    authors: Woollams AM,Halai A,Lambon Ralph MA

    更新日期:2018-11-01 00:00:00

  • α5 nAChR modulation of the prefrontal cortex makes attention resilient.

    abstract::A loss-of-function polymorphism in the α5 nicotinic acetylcholine receptor (nAChR) subunit gene has been linked to both drug abuse and schizophrenia. The α5 nAChR subunit is strategically positioned in the prefrontal cortex (PFC), where a loss-of-function in this subunit may contribute to cognitive disruptions in both...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1601-1

    authors: Howe WM,Brooks JL,Tierney PL,Pang J,Rossi A,Young D,Dlugolenski K,Guillmette E,Roy M,Hales K,Kozak R

    更新日期:2018-03-01 00:00:00

  • Comparative analysis of the serotonergic systems in the CNS of two lungfishes, Protopterus dolloi and Neoceratodus forsteri.

    abstract::The organization of the serotonergic system, one of the most important neurotransmitter systems in the brain, has been carefully analyzed in most vertebrate groups, and major shared characteristics have been described, although traits particular to each vertebrate class have also been found. The present study is the f...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0661-0

    authors: López JM,González A

    更新日期:2015-01-01 00:00:00

  • Principles of temporal association cortex organisation as revealed by connectivity gradients.

    abstract::To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02047-0

    authors: Blazquez Freches G,Haak KV,Bryant KL,Schurz M,Beckmann CF,Mars RB

    更新日期:2020-05-01 00:00:00

  • In vivo assembly of the axon initial segment in motor neurons.

    abstract::The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the A...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0578-7

    authors: Le Bras B,Fréal A,Czarnecki A,Legendre P,Bullier E,Komada M,Brophy PJ,Davenne M,Couraud F

    更新日期:2014-07-01 00:00:00

  • The laminar organization of the motor cortex in monodactylous mammals: a comparative assessment based on horse, chimpanzee, and macaque.

    abstract::The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze th...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1369-3

    authors: Cozzi B,De Giorgio A,Peruffo A,Montelli S,Panin M,Bombardi C,Grandis A,Pirone A,Zambenedetti P,Corain L,Granato A

    更新日期:2017-08-01 00:00:00

  • Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation.

    abstract::Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and agoraphobia in a contextual fear conditioning paradigm. In this study, we further analysed our previous data ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02102-w

    authors: Tan SZK,Temel Y,Chan AY,Mok ATC,Perucho JAU,Blokland A,Aquili L,Lim WL,Lim LW

    更新日期:2020-09-01 00:00:00

  • The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.

    abstract::The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0815-8

    authors: Felix RA 2nd,Magnusson AK,Berrebi AS

    更新日期:2015-09-01 00:00:00

  • Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2.

    abstract::The anatomic gene expression atlas (AGEA) of the adult mouse brain of the Allen Institute for Brain Science is a transcriptome-based atlas of the adult C57Bl/6 J mouse brain, based on the extensive in situ hybridization dataset of the Institute. This spatial mapping of the gene expression levels of mice under baseline...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02108-4

    authors: Kalafatakis I,Kalafatakis K,Tsimpolis A,Giannakeas N,Tsipouras M,Tzallas A,Karagogeos D

    更新日期:2020-09-01 00:00:00

  • TMS of the occipital face area modulates cross-domain identity priming.

    abstract::Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1768-0

    authors: Ambrus GG,Amado C,Krohn L,Kovács G

    更新日期:2019-01-01 00:00:00

  • Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated.

    abstract::The Ly-6 superfamily of proteins, which affects diverse processes in the immune system, has attracted renewed attention due to the ability of some Ly-6 proteins to bind to and modulate the function of neuronal nicotinic acetylcholine receptors (nAChRs). However, there is a scarcity of knowledge regarding the distribut...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0611-x

    authors: Thomsen MS,Cinar B,Jensen MM,Lyukmanova EN,Shulepko MA,Tsetlin V,Klein AB,Mikkelsen JD

    更新日期:2014-11-01 00:00:00

  • Altered cerebral blood flow and cerebrovascular function after voluntary exercise in adult mice.

    abstract::The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular f...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1409-z

    authors: Cahill LS,Bishop J,Gazdzinski LM,Dorr A,Stefanovic B,Sled JG

    更新日期:2017-11-01 00:00:00

  • The ontogeny of Mauthner cells in the brain of Labeo rohita as revealed by NADPH-d and nNOS immunohistochemistry.

    abstract::Nitric oxide (NO) is well demonstrated to act as a neuronal messenger in neurotransmission in vertebrate animals. We are for the first time reporting nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the Mauthner cells (MC) of the carp, Labeo rohita brain dur...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0292-7

    authors: Palande NV,Biswas S,Jadhao AG

    更新日期:2011-03-01 00:00:00

  • Systematic expression analysis of Hox genes at adulthood reveals novel patterns in the central nervous system.

    abstract::Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0965-8

    authors: Hutlet B,Theys N,Coste C,Ahn MT,Doshishti-Agolli K,Lizen B,Gofflot F

    更新日期:2016-04-01 00:00:00