Abstract：
:It is well established that environmental influences play a key role in sculpting neuronal connectivity in the brain. One example is the olfactory sensory map of topographic axonal connectivity. While intrinsic odorant receptor signaling in olfactory sensory neurons (OSN) determines anterior-posterior counter gradients of the axonal guidance receptors Neuropilin-1 and Plexin-A1, little is known about stimulus-dependent gradients of protein expression, which correlates with the functional organization of the olfactory sensory map along its dorsomedial (DM)-ventrolateral (VL) axis. Deficiency of the Alzheimer's β-secretase BACE1, which is expressed in a DM(low)-VL(high) gradient, results in OSN axon targeting errors in a DM > VL and gene dose-dependent manner. We show that expression of BACE1 and the all-trans retinoic acid (RA)-degrading enzyme Cyp26B1 form DM-VL counter gradients in the olfactory epithelium. Analyses of mRNA and protein levels in OSNs after naris occlusion, in mice deficient in the olfactory cyclic nucleotide-gated channel and in relation to onset of respiration, show that BACE1 and Cyp26B1 expression in OSNs inversely depend on neuronal activity. Overexpression of a Cyp26B1 or presence of a dominant negative RA receptor transgene selectively in OSNs, inhibit BACE1 expression while leaving the DM(low)-VL(high) gradient of the axonal guidance protein Neuropilin-2 intact. We conclude that stimulus-dependent neuronal activity can control the expression of the RA catabolic enzyme Cyp26B1 and downstream genes such as BACE1. This result is pertinent to an understanding of the mechanisms by which a topographic pattern of connectivity is achieved and modified as a consequence of graded gene expression and sensory experience.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Login H,Butowt R,Bohm Sdoi
10.1007/s00429-014-0783-zsubject
Has Abstractpub_date
2015-07-01 00:00:00pages
2143-57issue
4eissn
1863-2653issn
1863-2661journal_volume
220pub_type
杂志文章abstract：:The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0209-5
更新日期：2009-09-01 00:00:00
abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1514-z
更新日期：2018-03-01 00:00:00
abstract：:A recent virtual-lesion study using inhibitory repetitive transcranial magnetic stimulation (rTMS) confirmed the causal behavioral relevance of the precuneus in the evaluation of one's own memory performance (aka mnemonic metacognition). This study's goal is to elucidate how these TMS-induced neuromodulatory effects m...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01909-6
更新日期：2019-09-01 00:00:00
abstract：:Oscillation activities are the feature of neural network and correlated to different physiological states. The theta (θ) oscillation (2-7 Hz) has been reported in the basal ganglia, and the intrinsic resonance properties of individual neurons have provided a basis for this network oscillation. The basal ganglia neuron...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0361-6
更新日期：2012-04-01 00:00:00
abstract：:The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0703-7
更新日期：2015-03-01 00:00:00
abstract：:The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adop...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0355-4
更新日期：2012-04-01 00:00:00
abstract：:This study investigates the mechanism of action of spadin, a putative fast-acting peptidic antidepressant (AD) and a functional blocker of the K(+) TREK-1 channel, in relation with the medial prefrontal cortex (mPFC)-dorsal raphé (DRN) serotonergic (5-HT) neurons connectivity. Spadin increased 5-HT neuron firing rate ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0890-x
更新日期：2016-01-01 00:00:00
abstract：:Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0229-1
更新日期：2009-12-01 00:00:00
abstract：:Recent surges in tissue clearing technology have greatly advanced 3-dimensional (3D) volume imaging. Cleared tissues need to be stained with fluorescence probes for imaging but the current staining methods are too laborious and inefficient for thick 3D samples, which impedes the broad application of clearing technolog...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02160-0
更新日期：2021-01-01 00:00:00
abstract：:Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1691-4
更新日期：2018-09-01 00:00:00
abstract：:Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inco...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1650-0
更新日期：2018-07-01 00:00:00
abstract：:The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0815-8
更新日期：2015-09-01 00:00:00
abstract：:Multisensory integration does not only recruit higher-level association cortex, but also low-level and even primary sensory cortices. Here, we will describe and quantify two types of anatomical pathways, a thalamocortical and a corticocortical that possibly underlie short-latency multisensory integration processes in ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0694-4
更新日期：2015-03-01 00:00:00
abstract：:Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0965-8
更新日期：2016-04-01 00:00:00
abstract：:SK2 (KCa2.2) channels are voltage-independent Ca2+-activated K+ channels that regulate neuronal excitability in brain regions important for memory formation. In this study, we investigated the distribution and expression of SK2 channels in human brain by Western blot analysis and immunohistochemistry. Immunoblot analy...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1258-1
更新日期：2017-03-01 00:00:00
abstract：:Pitch is a primary perceptual dimension of sounds and is crucial in music and speech perception. When listening to melodies, most humans encode the relations between pitches into memory using an ability called relative pitch (RP). A small subpopulation, almost exclusively musicians, preferentially encode pitches using...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01872-2
更新日期：2019-06-01 00:00:00
abstract：:Pigeons are classic animal models for learning, memory, and cognition. The majority of the current understanding about avian neurobiology outside of the domain of the song system has been established using pigeons. Since MRI represents an increasingly relevant tool for comparative neuroscience, a 3-dimensional MRI-bas...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0400-y
更新日期：2013-01-01 00:00:00
abstract：:An account of work performed at the UNA laboratories since 1992 on the detection and description of interlaminar glial processes, is presented. The incidental observation (serendipity) of longer than expected glial processes in the superficial layers of the cerebral cortex in hemiparkinsonian Cebus apella monkeys, was...
journal_title：Brain structure & function
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00429-016-1332-8
更新日期：2017-04-01 00:00:00
abstract：:During the development of the central nervous system, the immature neurons suffer different migration processes. It is well known that Nkx2.1-positive ventricular layer give rise to critical tangential migrations into different regions of the developing forebrain. Our aim was to study this phenomenon in the hypothalam...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02163-x
更新日期：2020-12-01 00:00:00
abstract：:The midline and intralaminar thalamic nuclei (MITN), locus coeruleus (LC) and cingulate cortex contain nociceptive neurons. The MITN that project to cingulate cortex have a prominent innervation by norepinephrinergic axons primarily originating from the LC. The hypothesis explored in this study is that MITN neurons th...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0178-0
更新日期：2008-08-01 00:00:00
abstract：:Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1023-x
更新日期：2016-05-01 00:00:00
abstract：:Serotonergic cells are among the earliest neurons to be born in the developing central nervous system and serotonin is known to regulate the development of the nervous system. One of the major targets of the activity of serotonergic cells is the serotonin 1A receptor (5-HT1A), an ancestral archetypical serotonin recep...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0461-y
更新日期：2013-09-01 00:00:00
abstract：:A rapidly increasing number of studies are quantifying the system-level network architecture of the human brain based on structural-to-structural and functional-to-functional relationships. However, a largely unexplored area is the nature and existence of "cross-modal" structural-functional relationships, in which, fo...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-012-0391-8
更新日期：2013-01-01 00:00:00
abstract：:Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of biological organization (genetic, molecular, biochemi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1375-5
更新日期：2017-08-01 00:00:00
abstract：:Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-009-0214-8
更新日期：2009-09-01 00:00:00
abstract：:In the mammalian auditory system, the medial nucleus of the trapezoid body and the lateral superior olive (MNTB-LSO system) contribute to binaural intensity processing and lateralization. Localization precision varies with the sound frequencies. As recency of common ancestry with human beings increases, primates have ...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-008-0201-5
更新日期：2009-09-01 00:00:00
abstract：:Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0524-8
更新日期：2014-03-01 00:00:00
abstract：:To better understand information transfer along the hippocampal pathways and its plasticity, here we studied the antidromic responses of the dentate gyrus (DG) and CA3 to activation of the mossy fibers and Schaffer collaterals, respectively, in hippocampal slices from naïve and epileptic rats. We applied trains of 600...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-015-1003-1
更新日期：2016-05-01 00:00:00
abstract：:Prolactin is fundamental for the expression of maternal behaviour. In virgin female rats, prolactin administered upon steroid hormone priming accelerates the onset of maternal care. By contrast, the role of prolactin in mice maternal behaviour remains unclear. This study aims at characterizing central prolactin activi...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1254-5
更新日期：2017-03-01 00:00:00
abstract：:Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chr...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0713-0
更新日期：2015-03-01 00:00:00
