Abstract:
:Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inconsistent, likely due to population heterogeneity and small sample sizes. We investigated the genetic effect on caudate volume in a large sample of older adults without dementia. Results show that A-allele carriers have smaller caudate volume compared to non-carriers in relatively older adults (n = 167; Mage = 77.8 years), whereas the genotype did not influence caudate volume in a younger age group (n = 220; Mage = 62.8 years). Cognitive performance was not significantly affected by the DRD2 gene. Our findings extend previous observations by showing magnified genetic effects on brain volume in old age, and provide evidence for a link between a DA-related genetic polymorphism and grey matter volume in a brain region within the nigrostriatal dopaminergic pathway.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Li X,Papenberg G,Kalpouzos G,Bäckman L,Persson Jdoi
10.1007/s00429-018-1650-0subject
Has Abstractpub_date
2018-07-01 00:00:00pages
2653-2662issue
6eissn
1863-2653issn
1863-2661pii
10.1007/s00429-018-1650-0journal_volume
223pub_type
杂志文章abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1487-y
更新日期:2018-01-01 00:00:00
abstract::Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0769-x
更新日期:2015-07-01 00:00:00
abstract::The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0209-5
更新日期:2009-09-01 00:00:00
abstract::The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02077-8
更新日期:2020-06-01 00:00:00
abstract::To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02047-0
更新日期:2020-05-01 00:00:00
abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0336-7
更新日期:2012-04-01 00:00:00
abstract::The pedunculopontine nucleus (PPN) is composed of neurons with different connectivity patterns that express different neurochemical markers, display distinct firing characteristics and are topographically organized in functional domains across its rostro-caudal axis. Previous reports have shown that the caudal region ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0579-6
更新日期:2014-07-01 00:00:00
abstract::Reduction in the amount of brain-derived neurotrophic factor (BDNF) in corticostriatal afferents is thought to contribute to the vulnerability of medium spiny striatal neurons in Huntington's disease. In young Bdnf heterozygous ((+/-)) mice, striatal medium spiny neurons (MSNs) express less preprodynorphin (PPD), prep...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0282-9
更新日期:2010-08-01 00:00:00
abstract::The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. To...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02139-x
更新日期:2020-11-01 00:00:00
abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0921-7
更新日期:2016-01-01 00:00:00
abstract::The frontotemporal cortical network is associated with behaviours such as impulsivity and aggression. The health of the uncinate fasciculus (UF) that connects the orbitofrontal cortex (OFC) with the anterior temporal lobe (ATL) may be a crucial determinant of behavioural regulation. Behavioural changes can emerge afte...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1012-0
更新日期:2016-05-01 00:00:00
abstract::The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze th...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1369-3
更新日期:2017-08-01 00:00:00
abstract::Forebrain serotonin relevant for many psychological disorders arises in the hindbrain, primarily within the dorsal and median raphe nuclei (DR and MR). These nuclei are heterogeneous, containing several distinct groups of serotonin neurons. Here, new insight into the afferent and efferent connectivity of these areas i...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-015-1176-7
更新日期:2016-09-01 00:00:00
abstract::The auditory midbrain (inferior colliculus, IC) plays an important role in sound processing, acting as hub for acoustic information extraction and for the implementation of fast audio-motor behaviors. IC neurons are topographically organized according to their sound frequency preference: dorsal IC regions encode low f...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02188-2
更新日期:2021-01-01 00:00:00
abstract::The authors have retracted this article Jannesari et al. (2019) because an incorrect version of the article was published in error. The manuscript has been republished as Jannesari et al. (2020). All authors agree to this retraction. ...
journal_title:Brain structure & function
pub_type: 杂志文章,撤回出版物
doi:10.1007/s00429-020-02042-5
更新日期:2020-04-01 00:00:00
abstract::World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1322-x
更新日期:2017-07-01 00:00:00
abstract::Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1750-x
更新日期:2018-12-01 00:00:00
abstract::The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structure and function. However, these processes are formed during embryonic...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0768-y
更新日期:2015-07-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0560-4
更新日期:2014-07-01 00:00:00
abstract::The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0703-7
更新日期:2015-03-01 00:00:00
abstract::Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindle...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02118-2
更新日期:2020-09-01 00:00:00
abstract::Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wa...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0869-7
更新日期:2015-11-01 00:00:00
abstract::Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulatio...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1790-2
更新日期:2019-03-01 00:00:00
abstract::Brain pathology in Friedreich ataxia is characterized by progressive degeneration of nervous tissue in the brainstem, cerebellum and cerebellar peduncles. Evidence of cerebral involvement is however equivocal. This brain imaging study investigates cerebello-cerebral white matter connectivity in Friedreich ataxia with ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0547-1
更新日期:2014-05-01 00:00:00
abstract::The developing cerebellum is extremely vulnerable to hypoxia which can damage the Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) derived from activated microglia as in other brain areas. One-day-old rats were subjected to hypoxia following, w...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0491-5
更新日期:2014-01-01 00:00:00
abstract::Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity from R-fMRI is a challenging task, particularly when the ultima...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0524-8
更新日期:2014-03-01 00:00:00
abstract::Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1251-8
更新日期:2017-03-01 00:00:00
abstract::Very preterm infants (≤ 31 weeks gestational age) are at high risk for brain injury and delayed development. Applying functional connectivity and graph theory methods to resting state MRI data (fcMRI), we tested the hypothesis that preterm infants would demonstrate alterations in connectivity measures both globally an...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1707-0
更新日期:2018-11-01 00:00:00
abstract::The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1334-6
更新日期:2017-07-01 00:00:00