Abstract:
:Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wake-promoting inputs prompted us to investigate how layer VIb can modulate cortical arousal, using patch-clamp recordings and optogenetics in rat brain slices. We found that the majority of layer VIb neurons were excited by nicotinic agonists and orexin through the activation of nicotinic receptors containing α4-α5-β2 subunits and OX2 receptor, respectively. Specific effects of orexin on layer VIb neurons were potentiated by low nicotine concentrations and we used this paradigm to explore their intracortical projections. Co-application of nicotine and orexin increased the frequency of excitatory post-synaptic currents in the ipsilateral cortex, with maximal effect in infragranular layers and minimal effect in layer IV, as well as in the contralateral cortex. The ability of layer VIb to relay thalamocortical inputs was tested using photostimulation of channelrhodopsin-expressing fibers from the orexin-sensitive rhomboid nucleus in the parietal cortex. Photostimulation induced robust excitatory currents in layer VIa neurons that were not pre-synaptically modulated by orexin, but exhibited a delayed, orexin-dependent, component. Activation of layer VIb by orexin enhanced the reliability and spike-timing precision of layer VIa responses to rhomboid inputs. These results indicate that layer VIb acts as an orexin-gated excitatory feedforward loop that potentiates thalamocortical arousal.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Hay YA,Andjelic S,Badr S,Lambolez Bdoi
10.1007/s00429-014-0869-7subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3497-512issue
6eissn
1863-2653issn
1863-2661pii
10.1007/s00429-014-0869-7journal_volume
220pub_type
杂志文章abstract::The frontotemporal cortical network is associated with behaviours such as impulsivity and aggression. The health of the uncinate fasciculus (UF) that connects the orbitofrontal cortex (OFC) with the anterior temporal lobe (ATL) may be a crucial determinant of behavioural regulation. Behavioural changes can emerge afte...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1012-0
更新日期:2016-05-01 00:00:00
abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1487-y
更新日期:2018-01-01 00:00:00
abstract::Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0275-8
更新日期:2010-08-01 00:00:00
abstract::The anorexigenic neuropeptide NEFA/nucleobindin 2 (NUCB2)/nesfatin-1-containing neurons are distributed in the brain regions involved in feeding regulation, including the hypothalamic paraventricular nucleus (PVN). Functionally, NUCB2/nesfatin-1 neurons in the PVN regulate feeding through the hypothalamus and brain st...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1150-4
更新日期:2016-12-01 00:00:00
abstract::SK2 (KCa2.2) channels are voltage-independent Ca2+-activated K+ channels that regulate neuronal excitability in brain regions important for memory formation. In this study, we investigated the distribution and expression of SK2 channels in human brain by Western blot analysis and immunohistochemistry. Immunoblot analy...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1258-1
更新日期:2017-03-01 00:00:00
abstract::Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0781-1
更新日期:2015-07-01 00:00:00
abstract::Recently, neuroimaging-based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis has attracted researchers in the field, due to the increasing prevalence of the diseases. Unfortunately, the unfavorable high-dimensional nature of neuroimaging data, but a limited small number of samples available, make...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1059-y
更新日期:2016-06-01 00:00:00
abstract::The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preferenc...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02096-5
更新日期:2020-07-01 00:00:00
abstract::The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1716-z
更新日期:2018-11-01 00:00:00
abstract::Stress-related psychiatric diseases are nearly twice as prevalent in women compared to men. We recently showed in male rats that the resident-intruder model of social stress differentially engages stress-related circuitry that regulates norepinephrine-containing neurons of the locus coeruleus (LC) depending on coping ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01837-5
更新日期:2019-05-01 00:00:00
abstract::Diffusion-weighted magnetic resonance spectroscopy of brain metabolites offers unique access to compartment-specific microstructural information on neural tissue. Here, we investigated in detail the diffusion characteristics of the neuronal/axonal markers N-acetylaspartate + N-acetyl aspartyl glutamate (tNAA) in a sma...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0600-0
更新日期:2014-09-01 00:00:00
abstract::Patients with Parkinson's disease have difficulties with self-initiating a task and maintaining a steady task performance. We hypothesized that these difficulties relate to reorganization in the sensorimotor execution, cingulo-opercular task-set maintenance, and frontoparietal adaptive control networks. We tested this...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0981-8
更新日期:2016-04-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0226-4
更新日期:2010-03-01 00:00:00
abstract::To provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesicular glutamate transporter (VGLUT)1-immunopositive (+) and VGLUT2 + axon terminals (boutons) on the rat jaw-cl...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1636-y
更新日期:2018-06-01 00:00:00
abstract::Despite robust sex differences in behavioral responses to drugs of abuse, relatively little is known about structural sex differences in synaptic connectivity of reward circuits such as in the nucleus accumbens (NAc). Previously, we showed that distal dendritic spine density on medium spiny neurons in the NAc is highe...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0353-6
更新日期:2012-04-01 00:00:00
abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0160-2
更新日期:2007-12-01 00:00:00
abstract::Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02039-0
更新日期:2020-03-01 00:00:00
abstract::The cerebral cortex conveys major input to the granule cell layer of the cerebellar hemispheres by way of the pontine nuclei. Cerebrocortical projections terminate in multiple, widely distributed clusters in the pontine nuclei. This clustered organization is thought to provide the transition between the different orga...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-007-0145-1
更新日期:2007-07-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in syna...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0819-4
更新日期:2015-09-01 00:00:00
abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0336-7
更新日期:2012-04-01 00:00:00
abstract::Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0591-x
更新日期:2014-09-01 00:00:00
abstract::Sex differences are widespread across vertebrate nervous systems. Such differences are sometimes reflected in the neural substrate via neuroanatomical differences in brain region volume. One brain region that displays sex differences in its associated functions and pathologies is the striatum, including the caudate-pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-015-1158-9
更新日期:2016-11-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1677-2
更新日期:2018-09-01 00:00:00
abstract::The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1447-6
更新日期:2017-12-01 00:00:00
abstract::The developing cerebellum is extremely vulnerable to hypoxia which can damage the Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) derived from activated microglia as in other brain areas. One-day-old rats were subjected to hypoxia following, w...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0491-5
更新日期:2014-01-01 00:00:00
abstract::The rostral nucleus of the solitary tract (rNST) receives gustatory input via chorda tympani (CT) afferents from the anterior two-thirds of the tongue and transmits it to higher brain regions. To help understand how the gustatory information is processed at the 1st relay nucleus of the brain stem, we investigated the ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0959-6
更新日期:2016-03-01 00:00:00
abstract::Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1492-1
更新日期:2018-01-01 00:00:00
abstract::The Ly-6 superfamily of proteins, which affects diverse processes in the immune system, has attracted renewed attention due to the ability of some Ly-6 proteins to bind to and modulate the function of neuronal nicotinic acetylcholine receptors (nAChRs). However, there is a scarcity of knowledge regarding the distribut...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0611-x
更新日期:2014-11-01 00:00:00
abstract::The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitive...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0700-x
更新日期:2015-03-01 00:00:00