Abstract：
:The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is also involved in a selective and complex modulation of sensory information in the dorsal horn. However, little is known about the spinal network engaged by the CST and the organization of CS projections that may encode different cortical outputs to the spinal cord. This study addresses the issue of whether the CS system exerts parallel control on different spinal networks, which together participate in sensorimotor integration. Here, we show that in the adult rat, two different and partially intermingled CS neurons in the sensorimotor cortex activate, with different time latencies, distinct spinal cord neurons located in the dorsal horn and intermediate zone of the same segment. The fact that different populations of CS neurons project in a segregated manner suggests that CST is composed of subsystems controlling different spinal cord circuits that modulate motor outputs and sensory inputs in a coordinated manner.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Olivares-Moreno R,Moreno-Lopez Y,Concha L,Martínez-Lorenzana G,Condés-Lara M,Cordero-Erausquin M,Rojas-Piloni Gdoi
10.1007/s00429-017-1447-6subject
Has Abstractpub_date
2017-12-01 00:00:00pages
3945-3958issue
9eissn
1863-2653issn
1863-2661pii
10.1007/s00429-017-1447-6journal_volume
222pub_type
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