Claustrum circuit components for top-down input processing and cortical broadcast.

Abstract:

:Anterior cingulate cortex (ACC) input to the claustrum is required for top-down cognitive control of action. By virtue of its widespread cortical connectivity, the claustrum is anatomically situated to process and broadcast top-down signals from ACC to downstream cortices. To gain a deeper understanding of claustrum processing mechanisms, it is first critical to identify the projection neuron subtypes within claustrum, the intrinsic and extrinsic components regulating their firing, and the differential innervation of cortex by projection neuron subtypes. To this end, we used whole-cell patch-clamp electrophysiology in adult mouse brain slices to distinguish two spiny projection neuron subtypes in claustrum, referred to as type I and II neurons, and three aspiny interneuron subtypes, referred to as type III, IV, and V neurons. In response to optogenetic ACC afferent stimulation, type II neurons preferentially burst fire relative to type I neurons. This burst firing is calcium-dependent and is optimized by voltage-gated potassium channels. Finally, we find that visual cortices, parietal association cortex, and ACC receive input from type I and II neurons in differing proportions. These data reveal the diversity of claustrum neurons and mechanisms by which claustrum processes ACC command for spatiotemporal coordination of the cerebral cortex.

journal_name

Brain Struct Funct

authors

White MG,Mathur BN

doi

10.1007/s00429-018-1731-0

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3945-3958

issue

9

eissn

1863-2653

issn

1863-2661

pii

10.1007/s00429-018-1731-0

journal_volume

223

pub_type

杂志文章
  • The connectome of the basal ganglia.

    abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...

    journal_title:Brain structure & function

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00429-014-0936-0

    authors: Schmitt O,Eipert P,Kettlitz R,Leßmann F,Wree A

    更新日期:2016-03-01 00:00:00

  • Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex.

    abstract::Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0591-x

    authors: Ramos-Moreno T,Clascá F

    更新日期:2014-09-01 00:00:00

  • Differential frequency-dependent antidromic resonance of the Schaffer collaterals and mossy fibers.

    abstract::To better understand information transfer along the hippocampal pathways and its plasticity, here we studied the antidromic responses of the dentate gyrus (DG) and CA3 to activation of the mossy fibers and Schaffer collaterals, respectively, in hippocampal slices from naïve and epileptic rats. We applied trains of 600...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1003-1

    authors: Franco LM,Beltrán JQ,Tapia JA,Ortiz F,Manjarrez E,Gutiérrez R

    更新日期:2016-05-01 00:00:00

  • Diffusion tensor imaging of hippocampal network plasticity.

    abstract::Diffusion tensor imaging (DTI) has become a valuable tool to investigate white matter integrity in the brain. DTI also gives contrast in gray matter, which has been relatively little explored in studies assessing post-injury structural abnormalities. The present study was designed to compare white and gray matter reor...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0683-7

    authors: Sierra A,Laitinen T,Gröhn O,Pitkänen A

    更新日期:2015-03-01 00:00:00

  • Computational neuroanatomy of human stratum proprium of interparietal sulcus.

    abstract::Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1492-1

    authors: Uesaki M,Takemura H,Ashida H

    更新日期:2018-01-01 00:00:00

  • Blood total antioxidant status is associated with cortical glucose uptake and factors related to accelerated aging.

    abstract::Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total a...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02039-0

    authors: Palomar-Bonet M,Atienza M,Cantero JL

    更新日期:2020-03-01 00:00:00

  • Disinhibition of the prefrontal cortex leads to brain-wide increases in neuronal activation that are modified by spatial learning.

    abstract::Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1769-z

    authors: Auger ML,Meccia J,Galea LAM,Floresco SB

    更新日期:2019-01-01 00:00:00

  • Altered functional network connectivity in preterm infants: antecedents of cognitive and motor impairments?

    abstract::Very preterm infants (≤ 31 weeks gestational age) are at high risk for brain injury and delayed development. Applying functional connectivity and graph theory methods to resting state MRI data (fcMRI), we tested the hypothesis that preterm infants would demonstrate alterations in connectivity measures both globally an...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1707-0

    authors: Gozdas E,Parikh NA,Merhar SL,Tkach JA,He L,Holland SK

    更新日期:2018-11-01 00:00:00

  • Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress.

    abstract::Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1720-3

    authors: Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

    更新日期:2018-11-01 00:00:00

  • A volumetric study of the corpus callosum in 20s and 40s Korean people.

    abstract::The purpose of this study was to measure the average corpus callosum volume of normal Koreans (aged in their 20s or 40s) and to analyze the effects of gender, age, and body parameters, such as height and weight on corpus callosum size. Magnetic resonance brain images were recorded for 68 people in their 20s (29 men, 3...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0209-5

    authors: Lee BY,Sohn JH,Choi MH,Lee SJ,Kim HS,Yang JW,Choi JS,Kim HS,Yi JH,Tack GR,Chung SC

    更新日期:2009-09-01 00:00:00

  • Delineating function and connectivity of optokinetic hubs in the cerebellum and the brainstem.

    abstract::Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1461-8

    authors: Ruehl RM,Hinkel C,Bauermann T,Eulenburg PZ

    更新日期:2017-12-01 00:00:00

  • TBSS and probabilistic tractography reveal white matter connections for attention to object features.

    abstract::Selective attention to features of interest facilitates object processing in a cluttered and dynamic environment. Previous research found that distinct networks of regions across cortex are activated depending on the attended feature. These networks typically consist of posterior feature-preferring regions and anterio...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0631-6

    authors: Mayer KM,Vuong QC

    更新日期:2014-11-01 00:00:00

  • Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model.

    abstract::MRI was employed to follow the neurodegenerative foci and the localization of inflammatory cells by magnetically labeled CD4+ or CD8+ lymphocytes in the ischemia/reperfusion long-lived rats (9 and 13 months after 10 min of cardiac arrest). MRI of ischemic rats showed: (1) blood-brain barrier (BBB) leakage in the area ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0336-7

    authors: Sekeljic V,Bataveljic D,Stamenkovic S,Ułamek M,Jabłoński M,Radenovic L,Pluta R,Andjus PR

    更新日期:2012-04-01 00:00:00

  • Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors.

    abstract::Adult hippocampal neural stem cells (NSC) are an intriguing source for cell replacement or could serve as delivery vehicles for therapeutic genes. We recently reported selective transduction of adult mouse NSC in the DG by in vivo injection of GFP encoding adenoviral (Ad) vectors engineered to bind NSC-specific peptid...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0275-8

    authors: Hildebrandt S,Schmidt A,Stoll A,Schmitt O,Köhling R,Wree A,Haas SJ,Pützer BM

    更新日期:2010-08-01 00:00:00

  • Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract.

    abstract::Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specifi...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1682-5

    authors: Cornejo MP,De Francesco PN,García Romero G,Portiansky EL,Zigman JM,Reynaldo M,Perello M

    更新日期:2018-09-01 00:00:00

  • Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation.

    abstract::Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and agoraphobia in a contextual fear conditioning paradigm. In this study, we further analysed our previous data ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02102-w

    authors: Tan SZK,Temel Y,Chan AY,Mok ATC,Perucho JAU,Blokland A,Aquili L,Lim WL,Lim LW

    更新日期:2020-09-01 00:00:00

  • Intrinsic, stimulus-driven and task-dependent connectivity in human auditory cortex.

    abstract::A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1612-6

    authors: Häkkinen S,Rinne T

    更新日期:2018-06-01 00:00:00

  • Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity.

    abstract::Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these population...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0778-9

    authors: Nordenankar K,Smith-Anttila CJ,Schweizer N,Viereckel T,Birgner C,Mejia-Toiber J,Morales M,Leao RN,Wallén-Mackenzie Å

    更新日期:2015-07-01 00:00:00

  • Cellular activation in limbic brain systems during social play behaviour in rats.

    abstract::Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0558-y

    authors: van Kerkhof LW,Trezza V,Mulder T,Gao P,Voorn P,Vanderschuren LJ

    更新日期:2014-07-01 00:00:00

  • Stimulus-specific adaptation in the inferior colliculus of the mouse: anesthesia and spontaneous activity effects.

    abstract::Rapid behavioral responses to unexpected events in the acoustic environment are critical for survival. Stimulus-specific adaptation (SSA) is the process whereby some auditory neurons respond better to rare stimuli than to repetitive stimuli. Most experiments on SSA have been performed under anesthesia, and it is unkno...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0862-1

    authors: Duque D,Malmierca MS

    更新日期:2015-11-01 00:00:00

  • Neuronal networks underlying the conjoint modulation of response selection by subliminal and consciously induced cognitive conflicts.

    abstract::Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01866-0

    authors: Bensmann W,Zink N,Mückschel M,Beste C,Stock AK

    更新日期:2019-06-01 00:00:00

  • Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.

    abstract::Diverse stress stimuli induce long-lasting cognitive deficits, but the underlying molecular mechanisms are still incompletely understood. Here, we report three different stress models demonstrating that stress-inducible increases in microRNA-132 (miR-132) and consequent decreases in its acetylcholinesterase (AChE) tar...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0376-z

    authors: Shaltiel G,Hanan M,Wolf Y,Barbash S,Kovalev E,Shoham S,Soreq H

    更新日期:2013-01-01 00:00:00

  • Hippocampal signatures of awake targeted memory reactivation.

    abstract::Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulatio...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1790-2

    authors: Alm KH,Ngo CT,Olson IR

    更新日期:2019-03-01 00:00:00

  • Lectin-binding glycoproteins in the developing and adult snail CNS.

    abstract::Glycoproteins are complex molecules of the cell surface and the extracellular matrix (ECM) playing a fundamental role in the migration, guidance and synapse formation of neurons. In the present study, the glycosylated protein composition and localization were investigated in the adult and developing CNS of an aquatic ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-009-0229-1

    authors: Serfozo Z,Elekes K

    更新日期:2009-12-01 00:00:00

  • Thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis.

    abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0921-7

    authors: Lao Y,Wang Y,Shi J,Ceschin R,Nelson MD,Panigrahy A,Leporé N

    更新日期:2016-01-01 00:00:00

  • Bottom-up and top-down brain functional connectivity underlying comprehension of everyday visual action.

    abstract::How can the components of visual comprehension be characterized as brain activity? Making sense of a dynamic visual world involves perceiving streams of activity as discrete units such as eating breakfast or walking the dog. In order to parse activity into distinct events, the brain relies on both the perceptual (bott...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0160-2

    authors: Hanson SJ,Hanson C,Halchenko Y,Matsuka T,Zaimi A

    更新日期:2007-12-01 00:00:00

  • Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat.

    abstract::The medial prefrontal cortex (mPFC) has been associated with diverse functions including attentional processes, visceromotor activity, decision making, goal directed behavior, and working memory. Using retrograde tracing techniques, we examined, compared, and contrasted afferent projections to the four divisions of th...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-007-0150-4

    authors: Hoover WB,Vertes RP

    更新日期:2007-09-01 00:00:00

  • Loss of serum response factor in mature neurons in the dentate gyrus alters the morphology of dendritic spines and hippocampus-dependent behavioral tasks.

    abstract::Serum response factor (SRF) is a major transcription factor that regulates the expression of several plasticity-associated genes in the brain. Although the developmental expression of SRF in excitatory neurons is crucial for establishing proper hippocampal circuitry, no substantial evidence of its role in unstimulated...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01925-6

    authors: Nader K,Krysiak A,Beroun A,Pekala M,Szymanska M,Kuzniewska B,Radwanska K,Kaczmarek L,Kalita K

    更新日期:2019-11-01 00:00:00

  • Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation.

    abstract::The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adop...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0355-4

    authors: Wang YC,Ho UC,Ko MC,Liao CC,Lee LJ

    更新日期:2012-04-01 00:00:00

  • A 3-dimensional digital atlas of the ascending sensory and the descending motor systems in the pigeon brain.

    abstract::Pigeons are classic animal models for learning, memory, and cognition. The majority of the current understanding about avian neurobiology outside of the domain of the song system has been established using pigeons. Since MRI represents an increasingly relevant tool for comparative neuroscience, a 3-dimensional MRI-bas...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-012-0400-y

    authors: Güntürkün O,Verhoye M,De Groof G,Van der Linden A

    更新日期:2013-01-01 00:00:00