Abstract:
:Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulation of specific memory traces, as well as sequences, are apparent in humans during post-encoding memory reactivation. Thirty participants underwent functional imaging that consisted of interleaved encoding and rest periods. During an offline period of wakeful rest, we biased reactivation towards some memories by presenting sound cues that had previously been associated with particular stimulus sequences. Results showed that targeted hippocampal reactivation was biased towards cued memory sequences and that reactivation signatures preserved the temporal order of particular sequences. Importantly, the biased reactivation was related to differences in subsequent memory, suggesting that preferential reactivation may be a mechanism by which specific memory traces can be strengthened for enhanced subsequent memory retrieval.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Alm KH,Ngo CT,Olson IRdoi
10.1007/s00429-018-1790-2subject
Has Abstractpub_date
2019-03-01 00:00:00pages
713-726issue
2eissn
1863-2653issn
1863-2661pii
10.1007/s00429-018-1790-2journal_volume
224pub_type
杂志文章abstract::Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1492-1
更新日期:2018-01-01 00:00:00
abstract::The cerebellum receives sensory signals from spinocerebellar (lower limbs) and dorsal column nuclei (upper limbs) mossy fibers. In the cerebellum, mossy fibers terminate in bands that are topographically aligned with stripes of Purkinje cells. While much is known about the molecular heterogeneity of Purkinje cell stri...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0339-4
更新日期:2012-04-01 00:00:00
abstract::A history of intermittent, limited sucrose intake (LSI) attenuates the hypothalamic-pituitary-adrenocortical (HPA) axis stress response, and neuronal activity in the basolateral amygdala (BLA) is necessary for this HPA-dampening. LSI increases the expression of plasticity-associated genes in the BLA; however, the natu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1454-7
更新日期:2017-12-01 00:00:00
abstract::The basal ganglia of the laboratory rat consist of a few core regions that are specifically interconnected by efferents and afferents of the central nervous system. In nearly 800 reports of tract-tracing investigations the connectivity of the basal ganglia is documented. The readout of connectivity data and the collat...
journal_title:Brain structure & function
pub_type: 杂志文章,meta分析
doi:10.1007/s00429-014-0936-0
更新日期:2016-03-01 00:00:00
abstract::Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward cu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1559-z
更新日期:2018-04-01 00:00:00
abstract::Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0242-4
更新日期:2010-03-01 00:00:00
abstract::We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) usin...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0496-0
更新日期:2014-01-01 00:00:00
abstract::A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1612-6
更新日期:2018-06-01 00:00:00
abstract::Pigeons are classic animal models for learning, memory, and cognition. The majority of the current understanding about avian neurobiology outside of the domain of the song system has been established using pigeons. Since MRI represents an increasingly relevant tool for comparative neuroscience, a 3-dimensional MRI-bas...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-012-0400-y
更新日期:2013-01-01 00:00:00
abstract::Reduction in the amount of brain-derived neurotrophic factor (BDNF) in corticostriatal afferents is thought to contribute to the vulnerability of medium spiny striatal neurons in Huntington's disease. In young Bdnf heterozygous ((+/-)) mice, striatal medium spiny neurons (MSNs) express less preprodynorphin (PPD), prep...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-010-0282-9
更新日期:2010-08-01 00:00:00
abstract::Retinoic acid, the active form of the nutrient vitamin A, regulates several facets of neuronal plasticity in the hippocampus, including neurogenesis and synaptic strength, acting via specific retinoic acid receptors (RARs). Essential for conversion of vitamin A to retinoic acid is the enzyme retinaldehyde dehydrogenas...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0359-0
更新日期:2012-04-01 00:00:00
abstract::The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0560-4
更新日期:2014-07-01 00:00:00
abstract::Emerging data support roles for microRNA (miRNA) in the pathogenesis of various neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine volume. Recent work identified upregulation of miR-134 in experimental and human epilepsy....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0798-5
更新日期:2015-07-01 00:00:00
abstract::Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0781-1
更新日期:2015-07-01 00:00:00
abstract::The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01919-4
更新日期:2019-09-01 00:00:00
abstract::The authors have retracted this article Jannesari et al. (2019) because an incorrect version of the article was published in error. The manuscript has been republished as Jannesari et al. (2020). All authors agree to this retraction. ...
journal_title:Brain structure & function
pub_type: 杂志文章,撤回出版物
doi:10.1007/s00429-020-02042-5
更新日期:2020-04-01 00:00:00
abstract::World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1322-x
更新日期:2017-07-01 00:00:00
abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0530-x
更新日期:2014-03-01 00:00:00
abstract::Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-009-0214-8
更新日期:2009-09-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-017-1514-z
更新日期:2018-03-01 00:00:00
abstract::The frontal cortico-basal ganglia network plays a central role in action selection, associative learning, and motivation, processes requiring the integration of information from functionally distinct cortical regions. The cortico-striatal projection is a likely substrate of information integration, as terminal fields ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-018-1662-9
更新日期:2018-07-01 00:00:00
abstract::Hox proteins are key regulators of animal development, providing positional identity and patterning information to cells along the rostrocaudal axis of the embryo. Although their embryonic expression and function are well characterized, their presence and biological importance in adulthood remains poorly investigated....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-014-0965-8
更新日期:2016-04-01 00:00:00
abstract::The paraventricular nucleus of the thalamus (PVT) is part of a group of midline and intralaminar thalamic nuclei implicated in arousal and attention. Recent research points to anatomical and functional differences between the anterior (aPVT) and posterior PVT (pPVT). The present study re-examines the main sources of b...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-011-0360-7
更新日期:2012-04-01 00:00:00
abstract::The insula is a brain structure implicated in disparate cognitive, affective, and regulatory functions, including interoceptive awareness, emotional responses, and empathic processes. While classically considered a limbic region, recent evidence from network analysis suggests a critical role for the insula, particular...
journal_title:Brain structure & function
pub_type: 杂志文章,评审
doi:10.1007/s00429-010-0262-0
更新日期:2010-06-01 00:00:00
abstract::Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-016-1330-x
更新日期:2017-07-01 00:00:00
abstract::Similar to memory formation, memory extinction is also a new learning process that requires synaptic plasticity. Actin rearrangement is fundamental for synaptic plasticity, however, whether actin rearrangement in the infralimbic cortex (IL) plays a role in memory extinction, as well as the mechanisms underlying it, re...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0685-5
更新日期:2015-03-01 00:00:00
abstract::Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-019-01866-0
更新日期:2019-06-01 00:00:00
abstract::Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and agoraphobia in a contextual fear conditioning paradigm. In this study, we further analysed our previous data ...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-020-02102-w
更新日期:2020-09-01 00:00:00
abstract::The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders....
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0572-0
更新日期:2014-07-01 00:00:00
abstract::The effect of intracortical microstimulation has been studied in several cortical areas from motor to sensory areas. The frontal pole has received particular attention, and several microstimulation studies have been conducted in the frontal eye field, supplementary eye field, and the premotor ear-eye field, but no mic...
journal_title:Brain structure & function
pub_type: 杂志文章
doi:10.1007/s00429-013-0682-8
更新日期:2015-03-01 00:00:00