Hippocampal signatures of awake targeted memory reactivation.

Abstract:

:Dominant theories of episodic memory propose that a key mechanism of memory consolidation is replay-a process, whereby neural patterns of activation during learning are reinstated during offline post-learning periods. Here, we tested whether key signatures of replay defined by studies in rodents, such as recapitulation of specific memory traces, as well as sequences, are apparent in humans during post-encoding memory reactivation. Thirty participants underwent functional imaging that consisted of interleaved encoding and rest periods. During an offline period of wakeful rest, we biased reactivation towards some memories by presenting sound cues that had previously been associated with particular stimulus sequences. Results showed that targeted hippocampal reactivation was biased towards cued memory sequences and that reactivation signatures preserved the temporal order of particular sequences. Importantly, the biased reactivation was related to differences in subsequent memory, suggesting that preferential reactivation may be a mechanism by which specific memory traces can be strengthened for enhanced subsequent memory retrieval.

journal_name

Brain Struct Funct

authors

Alm KH,Ngo CT,Olson IR

doi

10.1007/s00429-018-1790-2

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

713-726

issue

2

eissn

1863-2653

issn

1863-2661

pii

10.1007/s00429-018-1790-2

journal_volume

224

pub_type

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