Abstract：
:Rapid behavioral responses to unexpected events in the acoustic environment are critical for survival. Stimulus-specific adaptation (SSA) is the process whereby some auditory neurons respond better to rare stimuli than to repetitive stimuli. Most experiments on SSA have been performed under anesthesia, and it is unknown if SSA sensitivity is altered by the anesthetic agent. Only a direct comparison can answer this question. Here, we recorded extracellular single units in the inferior colliculus of awake and anesthetized mice under an oddball paradigm that elicits SSA. Our results demonstrate that SSA is similar, but not identical, in the awake and anesthetized preparations. The differences are mostly due to the higher spontaneous activity observed in the awake animals, which also revealed a high incidence of inhibitory receptive fields. We conclude that SSA is not an artifact of anesthesia and that spontaneous activity modulates neuronal SSA differentially, depending on the state of arousal. Our results suggest that SSA may be especially important when nervous system activity is suppressed during sleep-like states. This may be a useful survival mechanism that allows the organism to respond to danger when sleeping.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Duque D,Malmierca MSdoi
10.1007/s00429-014-0862-1subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3385-98issue
6eissn
1863-2653issn
1863-2661pii
10.1007/s00429-014-0862-1journal_volume
220pub_type
杂志文章abstract：:The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respe...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-014-0911-9
更新日期：2016-01-01 00:00:00
abstract：:The baboon provides a model of photosensitive, generalized epilepsy. This study compares cerebral blood flow responses during intermittent light stimulation (ILS) between photosensitive (PS) and healthy control (CTL) baboons using H 2 (15) O-PET. We examined effective connectivity associated with visual stimulation in...
journal_title：Brain structure & function
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abstract：:Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...
journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章,meta分析
doi：10.1007/s00429-014-0936-0
更新日期：2016-03-01 00:00:00
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journal_title：Brain structure & function
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doi：10.1007/s00429-010-0242-4
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-016-1322-x
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0547-1
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-017-1409-z
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更新日期：2021-01-13 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章,评审
doi：10.1007/s00429-008-0192-2
更新日期：2008-09-01 00:00:00
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journal_title：Brain structure & function
pub_type： 历史文章,杂志文章,评审
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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更新日期：2016-12-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-011-0360-7
更新日期：2012-04-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-007-0145-1
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-013-0530-x
更新日期：2014-03-01 00:00:00
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journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-018-1636-y
更新日期：2018-06-01 00:00:00
abstract：:To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffu...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-020-02047-0
更新日期：2020-05-01 00:00:00
