Cortico-basal ganglia circuits involved in different motivation disorders in non-human primates.

Abstract:

:The ventral striatum (VS) is of particular interest in the study of neuropsychiatric disorders. In this study, performed on non-human primates, we associated local perturbation with monosynaptic axonal tracer injection into medial, central and lateral VS to characterize anatomo-functional circuits underlying the respective expression of sexual manifestations, stereotyped behaviors and hypoactive state associated with loss of food motivation. For the three behavioral effects, we demonstrated the existence of three distinct cortico-basal ganglia (BG) circuits that were topographically organized and overlapping at some cortical (orbitofrontal cortex, anterior cingulate cortex) and subcortical (caudal levels of BG) levels, suggesting interactions between motivation domains. Briefly, erection was associated with a circuit involving the orbitofrontal cortex, medial prefrontal cortex (areas 10, 11) and limbic parts of BG, i.e. medial parts of the pallidal complex and the substantia nigra pars reticulata (SNr). Stereotyped behavior was linked to a circuit involving the lateral orbitofrontal cortex (area 12/47) and limbic parts of the pallidal complex and of the SNr, while the apathetic state was underlined by a circuit involving not only the orbital and medial prefrontal cortex but also the lateral prefrontal cortex (area 8, 45), the anterior insula and the lateral parts of the medial pallidal complex and of the ventro-medial SNr. For the three behavioral effects, the cortico-BG circuits mainly involved limbic regions of the external and internal pallidum, as well as the limbic part of the substantia nigra pars reticulata (SNr), suggesting the involvement of both direct and indirect striatal pathways and both output BG structures. As these motivation disorders could still be induced in dopamine (DA)-depleted monkeys, we suggest that DA issued from the substantia nigra pars compacta (SNc) modulates their expression rather than causes them. Finally, this study may give some insights into the structure to target to achieve therapeutic benefits from deep brain stimulation in motivation disorders.

journal_name

Brain Struct Funct

authors

Sgambato-Faure V,Worbe Y,Epinat J,Féger J,Tremblay L

doi

10.1007/s00429-014-0911-9

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

345-64

issue

1

eissn

1863-2653

issn

1863-2661

pii

10.1007/s00429-014-0911-9

journal_volume

221

pub_type

杂志文章
  • Young, active and well-connected: adult-born neurons in the zebra finch are activated during singing.

    abstract::Neuronal replacement in the pallial song control nucleus HVC of adult zebra finches constitutes an interesting case of homeostatic plasticity; in spite of continuous addition and attrition of neurons in ensembles that code song elements, adult song remains remarkably invariant. New neurons migrate into HVC and later s...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1006-y

    authors: Tokarev K,Boender AJ,Claßen GA,Scharff C

    更新日期:2016-05-01 00:00:00

  • Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.

    abstract::Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1691-4

    authors: Kong V,Devenyi GA,Gallino D,Ayranci G,Germann J,Rollins C,Chakravarty MM

    更新日期:2018-09-01 00:00:00

  • The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability.

    abstract::The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate behaviors are also crucial for the adaptation of individuals to environmental cues. Thereby, all three components contribute to the cognitive fitness of an individual. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0882-x

    authors: Zhang CL,Houbaert X,Lepleux M,Deshors M,Normand E,Gambino F,Herzog E,Humeau Y

    更新日期:2015-11-01 00:00:00

  • Adolescent cocaine exposure induces prolonged synaptic modifications in medial prefrontal cortex of adult rats.

    abstract::Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1590-0

    authors: Zhu W,Ge X,Gao P,Li M,Guan Y,Guan X

    更新日期:2018-05-01 00:00:00

  • Analysis of pallial/cortical interneurons in key vertebrate models of Testudines, Anurans and Polypteriform fishes.

    abstract::The organization of the pallial derivatives across vertebrates follows a comparable elementary arrangement, although not all of them possess a layered cortical structure as sophisticated as the cerebral cortex of mammals. However, its expansion along evolution has only been possible by the development and coevolution ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02123-5

    authors: Jiménez S,López JM,Lozano D,Morona R,González A,Moreno N

    更新日期:2020-09-01 00:00:00

  • Y-P30 promotes axonal growth by stabilizing growth cones.

    abstract::The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the interaction of pleiotrophin and syndecan-3. We now show that Y-P30 activates Src kinase and extracellular signal-re...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0764-2

    authors: Neumann JR,Dash-Wagh S,Jüngling K,Tsai T,Meschkat M,Räk A,Schönfelder S,Riedel C,Hamad MI,Wiese S,Pape HC,Gottmann K,Kreutz MR,Wahle P

    更新日期:2015-07-01 00:00:00

  • Neural circuits underlying tongue movements for the prey-catching behavior in frog: distribution of primary afferent terminals on motoneurons supplying the tongue.

    abstract::The hypoglossal motor nucleus is one of the efferent components of the neural network underlying the tongue prehension behavior of Ranid frogs. Although the appropriate pattern of the motor activity is determined by motor pattern generators, sensory inputs can modify the ongoing motor execution. Combination of fluores...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0988-1

    authors: Kecskes S,Matesz C,Gaál B,Birinyi A

    更新日期:2016-04-01 00:00:00

  • Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease.

    abstract::Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-010-0242-4

    authors: Takahashi H,Brasnjevic I,Rutten BP,Van Der Kolk N,Perl DP,Bouras C,Steinbusch HW,Schmitz C,Hof PR,Dickstein DL

    更新日期:2010-03-01 00:00:00

  • Activation shift in elderly subjects across functional systems: an fMRI study.

    abstract::The functional specificity of brain areas is diminished with age and accompanied by the recruitment of additional brain regions in healthy older adults. This process has repeatedly been demonstrated within distinct functional domains, in particular the visual system. However, it is yet unclear, whether this phenomenon...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0530-x

    authors: Roski C,Caspers S,Lux S,Hoffstaedter F,Bergs R,Amunts K,Eickhoff SB

    更新日期:2014-03-01 00:00:00

  • White matter tract anatomy in the rhesus monkey: a fiber dissection study.

    abstract::Brain connectivity in non-human primates (NHPs) has been mainly investigated using tracer techniques and functional connectivity studies. Data on structural connections are scarce and come from diffusion tensor imaging (DTI), since gross anatomical white matter dissection studies in the NHP are lacking. The current st...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1718-x

    authors: Decramer T,Swinnen S,van Loon J,Janssen P,Theys T

    更新日期:2018-11-01 00:00:00

  • High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps.

    abstract::The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-019-01919-4

    authors: Huck J,Wanner Y,Fan AP,Jäger AT,Grahl S,Schneider U,Villringer A,Steele CJ,Tardif CL,Bazin PL,Gauthier CJ

    更新日期:2019-09-01 00:00:00

  • Thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis.

    abstract::Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and to designing efficient prevention and treatment strategies. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization o...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0921-7

    authors: Lao Y,Wang Y,Shi J,Ceschin R,Nelson MD,Panigrahy A,Leporé N

    更新日期:2016-01-01 00:00:00

  • GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

    abstract::The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0560-4

    authors: Roland JJ,Janke KL,Servatius RJ,Pang KC

    更新日期:2014-07-01 00:00:00

  • Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system.

    abstract::The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02104-8

    authors: Svobodová Burianová J,Syka J

    更新日期:2020-09-01 00:00:00

  • Dopaminergic innervation of pyramidal cells in the rat basolateral amygdala.

    abstract::Dopaminergic (DA) inputs to the basolateral nuclear complex of the amygdala (BLC) are critical for several important functions, including reward-related learning, drug-stimulus learning, and fear conditioning. Despite the importance of the DA projection to the BLC, very little is known about which neuronal subpopulati...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-008-0196-y

    authors: Muller JF,Mascagni F,McDonald AJ

    更新日期:2009-02-01 00:00:00

  • Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence.

    abstract::The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02077-8

    authors: Li R,Zhang J,Wu X,Wen X,Han B

    更新日期:2020-06-01 00:00:00

  • Relationship among interthalamic adhesion size, thalamic anatomy and neuropsychological functions in healthy volunteers.

    abstract::The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1334-6

    authors: Damle NR,Ikuta T,John M,Peters BD,DeRosse P,Malhotra AK,Szeszko PR

    更新日期:2017-07-01 00:00:00

  • Decreasing predictability of visual motion enhances feed-forward processing in visual cortex when stimuli are behaviorally relevant.

    abstract::Recent views of information processing in the (human) brain emphasize the hierarchical structure of the central nervous system, which is assumed to form the basis of a functional hierarchy. Hierarchical predictive processing refers to the notion that higher levels try to predict activity in lower areas, while lower le...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-016-1251-8

    authors: Kellermann T,Scholle R,Schneider F,Habel U

    更新日期:2017-03-01 00:00:00

  • Glutamatergic and cholinergic pedunculopontine neurons innervate the thalamic parafascicular nucleus in rats: changes following experimental parkinsonism.

    abstract::The tegmental pedunculopontine nucleus (PPN) is a basal ganglia-related structure that has recently gained renewed interest as a potential surgical target for the treatment of several aspects of Parkinson's disease. However, the underlying anatomical substrates sustaining the choice of the PPN nucleus as a surgical ca...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0317-x

    authors: Barroso-Chinea P,Rico AJ,Conte-Perales L,Gómez-Bautista V,Luquin N,Sierra S,Roda E,Lanciego JL

    更新日期:2011-11-01 00:00:00

  • TMS of the occipital face area modulates cross-domain identity priming.

    abstract::Accumulating evidence suggests that besides its function in early facial feature processing, the role of the right occipital face area (rOFA) extends to higher level, image-independent processing. Recent studies hint at the possibility that the activity of this region can be modulated by semantic information as well. ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1768-0

    authors: Ambrus GG,Amado C,Krohn L,Kovács G

    更新日期:2019-01-01 00:00:00

  • Puberty and testosterone shape the corticospinal tract during male adolescence.

    abstract::Some of the known sex differences in white matter emerge during adolescence. Here, we replicate and extend our previous findings of sex differences in the structure of the corticospinal tract (Perrin et al. 2009; Hervé et al. 2009). In a large normative sample of adolescents, we observed age × sex interactions in the ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0956-9

    authors: Pangelinan MM,Leonard G,Perron M,Pike GB,Richer L,Veillette S,Pausova Z,Paus T

    更新日期:2016-03-01 00:00:00

  • Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity.

    abstract::Despite robust sex differences in behavioral responses to drugs of abuse, relatively little is known about structural sex differences in synaptic connectivity of reward circuits such as in the nucleus accumbens (NAc). Previously, we showed that distal dendritic spine density on medium spiny neurons in the NAc is highe...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-011-0353-6

    authors: Wissman AM,May RM,Woolley CS

    更新日期:2012-04-01 00:00:00

  • Quantitative mapping of the local and extrinsic sources of GABA and Reelin to the layer Ia neuropil in the adult rat neocortex.

    abstract::Inputs to apical dendritic tufts have been considered to be crucial for associative learning, attention and similar ''feedback'' interactions and are located in neocortical layer Ia. Excitatory thalamic projections to apical tufts in layer Ia have been well characterized and their role in the cortical circuit has been...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-013-0591-x

    authors: Ramos-Moreno T,Clascá F

    更新日期:2014-09-01 00:00:00

  • Blood total antioxidant status is associated with cortical glucose uptake and factors related to accelerated aging.

    abstract::Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total a...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02039-0

    authors: Palomar-Bonet M,Atienza M,Cantero JL

    更新日期:2020-03-01 00:00:00

  • A three-dimensional digital atlas of the Nile crocodile (Crocodylus niloticus) forebrain.

    abstract::The phylogenetic position of crocodilians in relation to birds and mammals makes them an interesting animal model for investigating the evolution of the nervous system in amniote vertebrates. A few neuroanatomical atlases are available for reptiles, but with a growing interest in these animals within the comparative n...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-020-02028-3

    authors: Billings BK,Behroozi M,Helluy X,Bhagwandin A,Manger PR,Güntürkün O,Ströckens F

    更新日期:2020-03-01 00:00:00

  • The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function.

    abstract::This study investigates the mechanism of action of spadin, a putative fast-acting peptidic antidepressant (AD) and a functional blocker of the K(+) TREK-1 channel, in relation with the medial prefrontal cortex (mPFC)-dorsal raphé (DRN) serotonergic (5-HT) neurons connectivity. Spadin increased 5-HT neuron firing rate ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0890-x

    authors: Moha ou Maati H,Bourcier-Lucas C,Veyssiere J,Kanzari A,Heurteaux C,Borsotto M,Haddjeri N,Lucas G

    更新日期:2016-01-01 00:00:00

  • Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.

    abstract::Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-017-1487-y

    authors: Squires KE,Gerber KJ,Pare JF,Branch MR,Smith Y,Hepler JR

    更新日期:2018-01-01 00:00:00

  • How do cortico-striatal projections impact on downstream pallidal circuitry?

    abstract::The frontal cortico-basal ganglia network plays a central role in action selection, associative learning, and motivation, processes requiring the integration of information from functionally distinct cortical regions. The cortico-striatal projection is a likely substrate of information integration, as terminal fields ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-018-1662-9

    authors: Heilbronner SR,Meyer MAA,Choi EY,Haber SN

    更新日期:2018-07-01 00:00:00

  • Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset.

    abstract::In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer ...

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-014-0853-2

    authors: Sasaki T,Aoi H,Oga T,Fujita I,Ichinohe N

    更新日期:2015-11-01 00:00:00

  • The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders.

    abstract::Interaction between the hippocampus and the medial prefrontal cortex (mPFC) has been identified as a key target in several neuropsychiatric disorders. However, the hippocampus-mPFC (H-PFC) pathway has not been outlined in mice, which are increasingly the leading choice for new animal models for neurological disorders....

    journal_title:Brain structure & function

    pub_type: 杂志文章

    doi:10.1007/s00429-015-1023-x

    authors: Tripathi A,Schenker E,Spedding M,Jay TM

    更新日期:2016-05-01 00:00:00