Abstract：
:The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the interaction of pleiotrophin and syndecan-3. We now show that Y-P30 activates Src kinase and extracellular signal-regulated kinase (ERK). Y-P30 promotes axonal growth of mouse embryonic stem cell-derived neurons, embryonic mouse spinal cord motoneurons, perinatal rat retinal neurons, and rat cortical neurons. Y-P30-mediated axon growth was dependent on heparan sulfate chains. Y-P30 decreased the proportion of collapsing/degenerating growth cones of cortical axons in an Src and ERK-dependent manner. Y-P30 increased for 90 min in axonal growth cones the level of Tyr418-phosphorylated Src kinase and the amount of F-actin, and transiently the level of Tyr-phosphorylated ERK. Levels of total Src kinase, actin, GAP-43, cortactin and the glutamate receptor subunit GluN2B were not altered. When exposed to semaphorin-3a, Y-P30 protected a significant fraction of growth cones of cortical neurons from collapse. These results suggest that Y-P30 promotes axonal growth via Src- and ERK-dependent mechanisms which stabilize growth cones and confer resistance to collapsing factors.
journal_name
Brain Struct Functjournal_title
Brain structure & functionauthors
Neumann JR,Dash-Wagh S,Jüngling K,Tsai T,Meschkat M,Räk A,Schönfelder S,Riedel C,Hamad MI,Wiese S,Pape HC,Gottmann K,Kreutz MR,Wahle Pdoi
10.1007/s00429-014-0764-2subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1935-50issue
4eissn
1863-2653issn
1863-2661journal_volume
220pub_type
杂志文章abstract：:The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in ne...
journal_title：Brain structure & function
pub_type： 杂志文章
doi：10.1007/s00429-019-01919-4
更新日期：2019-09-01 00:00:00
abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...
journal_title：Brain structure & function
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更新日期：2018-12-01 00:00:00
abstract：:The insula is a brain structure implicated in disparate cognitive, affective, and regulatory functions, including interoceptive awareness, emotional responses, and empathic processes. While classically considered a limbic region, recent evidence from network analysis suggests a critical role for the insula, particular...
journal_title：Brain structure & function
pub_type： 杂志文章,评审
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abstract：:Goal-directed behavior has been shown to be affected by consciously and subliminally induced conflicts. Both types of conflict conjointly modulate behavioral performance, but the underlying neuronal mechanisms have remained unclear. While cognitive control is linked to oscillations in the theta frequency band, there a...
journal_title：Brain structure & function
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abstract：:Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT release sites (boutons) in certain bra...
journal_title：Brain structure & function
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abstract：:In the embryonic head of vertebrates, neurogenic and non-neurogenic ectodermal placodes arise from the panplacodal primordium. Whether and how growth processes of the ectodermal layer, changes in the transcriptional precursor cell profile, or positional changes among precursor cells contribute to interplacodal boundar...
journal_title：Brain structure & function
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abstract：:Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue function. Anatomically, whilst the peripheral sympathetic and parasympathetic pathways are separate, the distribution of premotor neurons in higher brain regions often overlaps. This co-distrib...
journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章,评审
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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更新日期：2017-07-01 00:00:00
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journal_title：Brain structure & function
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更新日期：2017-03-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章
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journal_title：Brain structure & function
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 杂志文章,评审
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
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journal_title：Brain structure & function
pub_type： 历史文章,杂志文章,评审
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journal_title：Brain structure & function
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